Quantitative Studies of Binding between Synthetic Galactosyl Ceramide Analogues and HIV-1 Gp120 at Planar Membrane Surfaces
摘要:
A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgp120 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified. This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gp120.
The present invention relates to a method of forming polymer on the surface of polymer particles, the method comprising:
(i) providing a dispersion comprising a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and a RAFT agent as a stabiliser for said organic phase;
(ii) polymerising the one or more ethylenically unsaturated monomers under the control of the RAFT agent to form an aqueous dispersion of seed polymer particles;
(iii) crosslinking the seed polymer particles;
(iv) swelling the crosslinked seed particles with one or more ethylenically unsaturated monomers to form an aqueous dispersion of monomer swollen crosslinked seed polymer particles;
(v) increasing the temperature of the monomer swollen crosslinked seed polymer particles to expel at least some of the monomer therein onto the surface of the particles; and
polymerising at least the expelled monomer to form polymer on the surface of the particles.
申请人:COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
公开号:US20160375143A1
公开(公告)日:2016-12-29
The invention relates to branched polymer comprising a support moiety and at least three homopolymer chains each covalently coupled to and extending from the support moiety, wherein the at least three homopolymer chains include a cationic homopolymer chain, a hydrophilic homopolymer chain, and a hydrophobic homopolymer chain.
Compositions of modified carbon products and amphiphilic ions and
申请人:Cabot Corporation
公开号:US05698016A1
公开(公告)日:1997-12-16
A composition is disclosed which comprises a) an amphiphilic ion, and b) a modified carbon product comprising carbon having attached at least one organic group. The organic group has a charge opposite to the amphiphilic ion. Also disclosed are aqueous and non-aqueous ink and coating compositions incorporating this composition. Ink jet ink compositions are further described incorporating this composition.
The present invention relates to a method for modifying line edge roughness on a lithographically-produced feature in a material, the method comprising applying a block copolymer to an area on the feature having line edge roughness, the block copolymer comprising a charged hydrophilic polymer block and a non-charged hydrophilic polymer block.
Detergent composition with a suds-regulating system
申请人:THE PROCTER & GAMBLE COMPANY
公开号:EP0000216A1
公开(公告)日:1979-01-10
Detergent compositions having regulated suds over a broad range of usage and laundry temperature conditions containing an organic surface-active agent and a mixture of suds regulating components are disclosed. The suds regulating agent is a mixture of a liquid hydrocarbon in conjunction with an adjunct material, which can be a solid hydrocarbon or a fatty ester, and a hydrophobic silica suds regulating agent. The subject compositions are capable of providing effective and uniform suds regulating activity over the complete range of laundry temperatures from ambient temperature up to the boil and are generally independent of soil load, water hardness and other incidental factors known to interfere with the suds regulating activity.