naphthalenesulfonamide, 5-(dimethylamino)-N-(2-bromoethyl)- | 282530-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphthalenesulfonamide, 5-(dimethylamino)-N-(2-bromoethyl)-
• 英文别名: N-(2-bromoethyl)-5-(dimethylamino)naphthalene-1-sulfonamide
• CAS: 282530-04-5
• 化学式: C₁₄H₁₇BrN₂O₂S
• 分子量: 357.271
• InChiKey: GMNSCBZLDRZXBP-UHFFFAOYSA-N

物化性质

• 沸点：
  475.6±55.0 °C(Predicted)
• 密度：
  1.477±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  naphthalenesulfonamide, 5-(dimethylamino)-N-(2-bromoethyl)- 在 sodium azide 、 copper(ll) sulfate pentahydrate 、 sodium ascorbate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Profiling of Haemophilus influenzae strain R2866 with carbohydrate-based covalent probes

  摘要：

  在流感嗜血杆菌中使用共价、基于碳水化合物的探针标记蛋白质，可在裂解液和完整细胞中产生独特的靶标谱。

  DOI：

  10.1039/d0ob01971b
• 作为产物：
  描述：

  2-(5-dimethylaminonaphthalene-1-sulfonamido)ethyl methanesulfonate 在 lithium bromide 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 以92 mg的产率得到naphthalenesulfonamide, 5-(dimethylamino)-N-(2-bromoethyl)-
  参考文献：
  名称：

  Zn2+ fluorescent chemosensors and the influence of their spacer length on tuning Zn2+ selectivityElectronic supplementary information (ESI) available: job plot, partial 1H NMR spectra of free 3 and the 3–Zn2+ complex, Ca2+ and Mg2+ interference for Zn2+ sensing of 3, Kd measurements, and buffer preparation. See http://www.rsc.org/suppdata/p2/b2/b200462c/

  摘要：

  基于配位增强荧光（CHEF）机制的Zn2+荧光化学传感器被制备出来，并通过控制间隔基长度实现了对Zn2+选择性的精细调节。对金属离子的荧光发射响应显示，Co2+、Cu2+和Ni2+使荧光减弱，而Ca2+、Cd2+和Zn2+使荧光增强。在3号传感器中实现了对Zn2+的最大选择性，优于Ca2+和Cd2+。基本结合特性（化学计量比、表观解离常数和pH依赖性）通过荧光光谱法测量。3号传感器与Zn2+的Job图分析表明形成了1:1的复合物。表观解离常数Kd在pH 7.5时为0.98（±0.43）nM [50 mM HEPES缓冲液，I = 0.1 (NaNO3)]。在pH超过7的区域，2号传感器及其与Zn2+的复合物的荧光强度平稳，表明荧光测量受生理pH变化的影响不大。

  DOI：

  10.1039/b200462c

文献信息

• Topical compositions comprising protected functional thiols
  申请人：——

  公开号：US20020012639A1

  公开（公告）日：2002-01-31

  This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr) m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.

  这项发明涉及一种用于处理氨基酸基底的局部组合物，包括具有以下结构的受保护硫化合物R—(S—Pr)m，其中R是功能基团，S是硫，Pr是一个杂环保护基团，m是介于1和100之间的整数。该发明还涉及包含该受保护硫化合物和一个活化机制的系统。本发明的受保护硫化合物可用于头发护理组合物、纺织品护理组合物、化妆品组合物、口腔护理组合物、皮肤护理、指甲护理、洗涤护理、痤疮护理和动物护理组合物。本发明的优选实施例提供了一种改性紫外线吸收剂和一种改性抗氧化剂，以及制备它们和包含它们的组合物的方法。
• A One-Pot Three-Component Radiochemical Reaction for Rapid Assembly of ¹²⁵I-Labeled Molecular Probes
  作者：Ran Yan、Kerstin Sander、Eva Galante、Vineeth Rajkumar、Adam Badar、Mathew Robson、Ethaar El-Emir、Mark F. Lythgoe、R. Barbara Pedley、Erik Årstad

  DOI：10.1021/ja307926g

  日期：2013.1.16

  biological activity. Herein, we report a one-pot, three-component, copper(II)-mediated reaction of azides, alkynes, and [(125)I]iodide to yield 5-[(125)I]iodo-1,2,3-triazoles. Using a selection of azides and alkynes in a combinatorial approach, we have synthesized a library of structurally diverse (125)I-labeled triazoles functionalized with bioconjugation groups, fluorescent dyes, and biomolecules. Our

  核成像与放射性示踪剂相结合，可以对体内生化事件进行无创测量。然而，由于缺乏快速组装具有先决生物活性的放射性标记分子的方法，对示踪剂的获取仍然有限。在此，我们报道了一种单锅、三组分、铜 (II) 介导的叠氮化物、炔烃和 [(125)I] 碘化物反应生成 5-[(125)I]iodo-1,2,3 -三唑类。我们在组合方法中使用选择的叠氮化物和炔烃，合成了一个结构多样的 (125) I 标记的三唑库，这些三唑具有生物共轭基团、荧光染料和生物分子功能化。我们的初步生物学评估表明，5-[(125)I]iodo-1,2,3-triazoles 在体内对脱碘具有抗性，无论是作为小分子探针还是作为抗体偶联物。
• A new imidazolium/sulfonamide linked ferrocene-dansyl dyad for dual-channel recognition of anion
  作者：Hong-Wei Huang、Zhao-Hui Xin、Jian-Zhong Nan、Yong Chen、Qian-Yong Cao

  DOI：10.1016/j.ica.2020.120026

  日期：2021.1

  A new ferrocene-dansyl dyad (Fc-DAS), in which the ferrocene unit and the dansyl fluorophore are linked by the imidazolium and the sulfonamide groups, has been designed. The recognition ability of probe toward various anions (H2PO4-, F-, Cl-, Br-, I- and AcO-) has been investigated by fluorescent spectrum and electro-chemical techniques (differential pulse voltammetry and cyclic voltammetry). This probe shows fluorescent sensing of F- over other anions with a quenching effect in CH3CN solution. However, the electrochemical experiments reveal that the binding of H2PO4-, F- and AcO- anions leads the potential of probe a cathodic shift, with the shift magnitude H2PO4- > F- > AcO-. Furthermore, the binding mechanisms between Fc-DAS and anions have been investigated using H-1 NMR titration and density functional theory (DFT) calculations.
• Ratiometric fluorescence probe for two-photon bioimaging of Cr3+ in living cells
  作者：Zhiguo Zhou、Ying Li、Yongquan Wu

  DOI：10.1016/j.tetlet.2014.06.014

  日期：2014.7

  We presented a ratiometric fluorescent probe dansylamide-rhodamine dyad (DANS-RE) for selectively detecting Cr3+ in semi-aqueous solution. The detection mechanism relies on the fluorescent resonance energy transfer (FRET) process from the dansylamide (energy donor) to the rhodamine (energy acceptor) after the addition of Cr3+. The cell-permeability of DANS-RE was confirmed by the two-photon fluorescence microscopy experiments, which demonstrated DANS-RB was a good candidate for monitoring the intracellular Cr3+ level with the ratiometric fluorescent method. Combining the excellent selectivity, the ratiometric quantitative detection, and the cell-permeability, DANS-RB may find a broad application in the investigation on biologically relevant species in living cells. (C) 2014 Elsevier Ltd. All rights reserved.
• US6495125B2
  申请人：——

  公开号：US6495125B2

  公开（公告）日：2002-12-17