(S)-1-Benzyloxy-3-dodecyloxy-propan-2-ol | 90904-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-Benzyloxy-3-dodecyloxy-propan-2-ol
• 英文别名: (2S)-1-dodecoxy-3-phenylmethoxypropan-2-ol
• CAS: 90904-31-7
• 化学式: C₂₂H₃₈O₃
• 分子量: 350.542
• InChiKey: CAJJSSXCVQAYBH-QFIPXVFZSA-N

物化性质

• 沸点：
  463.6±35.0 °C(Predicted)
• 密度：
  0.963±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25.0
• 可旋转键数：
  17.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-1-Benzyloxy-3-dodecyloxy-propan-2-ol 在 10percent Pd/C 4-二甲氨基吡啶 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of Lipophilic Aldehydes and Study of Their Inhibition Effect on Human Digestive Lipases

  摘要：

  [GRAPHICS]Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.

  DOI：

  10.1021/ol026039l
• 作为产物：
  描述：

  (R)-4-苄氧甲基-2,2-二甲基-1,3-二氧戊环 在 盐酸 、 sodium hydroxide 、 四丁基硫酸氢铵 作用下， 以 甲醇 、 苯 为溶剂， 生成 (S)-1-Benzyloxy-3-dodecyloxy-propan-2-ol
  参考文献：
  名称：

  Synthesis of Lipophilic Aldehydes and Study of Their Inhibition Effect on Human Digestive Lipases

  摘要：

  [GRAPHICS]Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.

  DOI：

  10.1021/ol026039l