N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)ethyl]ammonium bromide | 1103534-20-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)ethyl]ammonium bromide
• 英文别名: (2-Ethoxy-2-oxoethyl)-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;bromide；(2-ethoxy-2-oxoethyl)-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;bromide
• CAS: 1103534-20-8
• 化学式: Br*C₁₂H₂₂NO₄
• 分子量: 324.215
• InChiKey: SQCIMNRAWBOJIE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.25
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)ethyl]ammonium bromide 、 sodium salicylate 以 水 为溶剂， 反应 24.0h， 生成 N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)ethyl]ammonium salicylate
  参考文献：
  名称：

  Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean

  摘要：

  A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylinethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to in the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.

  DOI：

  10.1021/la101542m
• 作为产物：
  描述：

  甲基丙烯酸二甲氨乙酯 、 溴乙酸乙酯 以 乙腈 为溶剂， 反应 18.0h， 以90%的产率得到N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)ethyl]ammonium bromide
  参考文献：
  名称：

  Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean

  摘要：

  A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylinethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to in the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.

  DOI：

  10.1021/la101542m

文献信息

• Systems, devices, and methods including implantable devices with anti-microbial properties
  申请人：Gearbox, LLC

  公开号：US10426857B2

  公开（公告）日：2019-10-01

  Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

  所述系统、设备、方法和组合物用于提供一种主动可控植入物，其配置可用于监控、治疗或防止微生物生长或附着在植入物上。
• SYSTEM, DEVICES, AND METHODS INCLUDING ACTIVELY-CONTROLLABLE STERILIZING EXCITATION DELIVERY IMPLANTS
  申请人：Searete LLC

  公开号：EP2384168A1

  公开（公告）日：2011-11-09
• ACTIVELY-CONTROLLABLE STERILIZING EXCITATION DELIVERY IMPLANTS
  申请人：Searete LLC

  公开号：EP2384168B1

  公开（公告）日：2014-10-08
• SYSTEMS, DEVICES, AND METHODS INCLUDING INFECTION-FIGHTING AND MONITORING SHUNTS
  申请人：Searete LLC

  公开号：EP2401005A1

  公开（公告）日：2012-01-04
• SYSTEMS, DEVICES, AND METHODS INCLUDING CATHETERS CONFIGURED TO MONITOR AND INHIBIT BIOFILM FORMATION
  申请人：Searete LLC

  公开号：EP2506771A1

  公开（公告）日：2012-10-10