2,15-Di-non-8-enyl-hexadecane-1,16-diol | 201670-73-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,15-Di-non-8-enyl-hexadecane-1,16-diol
• 英文别名: 2,15-bis(non-8-enyl)hexadecane-1,16-diol
• CAS: 201670-73-7
• 化学式: C₃₄H₆₆O₂
• 分子量: 506.897
• InChiKey: AVTAASGZVBGZQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.72
• 重原子数：
  36.0
• 可旋转键数：
  31.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2,15-Di-non-8-enyl-hexadecane-1,16-diol 在 4-二甲氨基吡啶 、 sodium hydroxide 、 lithium aluminium tetrahydride 、 双氧水 、 二(3-甲基丁烷-2-基)硼烷 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 41.0h， 生成 (10RS,23RS)-10,23-dimethyldotriacontane-1,32-diol
  参考文献：
  名称：

  Simple and high yield synthesis of (±)10,10′-dimethyl-dotriacontan-1,1′-diol as a building block for branched bola compounds. Preparation of (±)10,10′-dimethyl-dotriaconta-1,1′-diyl-bis[2-(trimethylammonio)ethyl phosphate] and the corresponding unbranched equivalent

  摘要：

  The synthesis of a specially methyl branched bipolar hydrocarbon chain is described by alkylation of 1,12-dibro-mododecane with two equivalents of the dianion of undec-10-enoic acid. The subsequent transformation includes the reduction of the carboxyl groups to methyl branches and the hydroboration of the terminal olefines. The resulting 1,32 diol is suitable for phosphorylation in order to form the corresponding 1,1'bis-phosphocholine. (C) 1997 Elsevier Science Ireland Ltd.

  DOI：

  10.1016/s0009-3084(97)00073-x
• 作为产物：
  描述：

  2,15-Di-non-8-enyl-hexadecanedioic acid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 10.0h， 以95%的产率得到2,15-Di-non-8-enyl-hexadecane-1,16-diol
  参考文献：
  名称：

  Simple and high yield synthesis of (±)10,10′-dimethyl-dotriacontan-1,1′-diol as a building block for branched bola compounds. Preparation of (±)10,10′-dimethyl-dotriaconta-1,1′-diyl-bis[2-(trimethylammonio)ethyl phosphate] and the corresponding unbranched equivalent

  摘要：

  The synthesis of a specially methyl branched bipolar hydrocarbon chain is described by alkylation of 1,12-dibro-mododecane with two equivalents of the dianion of undec-10-enoic acid. The subsequent transformation includes the reduction of the carboxyl groups to methyl branches and the hydroboration of the terminal olefines. The resulting 1,32 diol is suitable for phosphorylation in order to form the corresponding 1,1'bis-phosphocholine. (C) 1997 Elsevier Science Ireland Ltd.

  DOI：

  10.1016/s0009-3084(97)00073-x