9,10-Dihydro-9,10-dioxo-7-hydroxyanthracene-2-carboxylic acid | 161802-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9,10-Dihydro-9,10-dioxo-7-hydroxyanthracene-2-carboxylic acid
• 英文别名: 7-hydroxy-9,10-dioxoanthracene-2-carboxylic acid
• CAS: 161802-08-0
• 化学式: C₁₅H₈O₅
• 分子量: 268.226
• InChiKey: SDOZHIOKZWFZOW-UHFFFAOYSA-N

物化性质

• 沸点：
  550.3±50.0 °C(Predicted)
• 密度：
  1.577±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 9,10-Dihydro-9,10-dioxo-7-hydroxyanthracene-2-carboxylic acid 在 硫酸 作用下， 以61%的产率得到7-acetoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid
  参考文献：
  名称：

  Anthraquinones related to rhein inhibit glucose uptake into chondrocytes. A mechanism for anti-osteoarthritis drugs?

  摘要：

  Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of anthraquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00102-9
• 作为产物：
  描述：

  2-蒽羧酸,7-氟-9,10-二氢-9,10-二羰基- 在 sodium hydroxide 、 四丁基氯化铵 、 水 作用下， 以 氯苯 为溶剂， 反应 6.0h， 以98%的产率得到9,10-Dihydro-9,10-dioxo-7-hydroxyanthracene-2-carboxylic acid
  参考文献：
  名称：

  Anthraquinones related to rhein inhibit glucose uptake into chondrocytes. A mechanism for anti-osteoarthritis drugs?

  摘要：

  Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of anthraquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00102-9

文献信息

• Pharmaceutical compounds
  申请人：Eli Lilly and Company

  公开号：US05430067A1

  公开（公告）日：1995-07-04

  Pharmaceutical compounds as follows: 9,10-dihydro-9,10-dioxo-4,5,8-trimethoxyanthracene-2-carboxylic acid, 4,5-diethoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, 9,10-dihydro-9,10-dioxo-4,5-dipropoxyanthracene-2-carboxylic acid, 4,5-dibutoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, 9,10-dihydro-5,8-dimethoxy-9,10-dioxoanthracene-2-carboxylic acid, 7-acetoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid; and salts and esters thereof.

  以下是药物化合物的中文翻译：9,10-二氢-9,10-二氧-4,5,8-三甲氧基蒽-2-羧酸，4,5-二乙氧基-9,10-二氢-9,10-二氧基蒽-2-羧酸，9,10-二氢-9,10-二氧-4,5-二丙氧基蒽-2-羧酸，4,5-二丁氧基-9,10-二氢-9,10-二氧基蒽-2-羧酸，9,10-二氢-5,8-二甲氧基-9,10-二氧基蒽-2-羧酸，7-乙酰氧基-9,10-二氢-9,10-二氧基蒽-2-羧酸；及其盐和酯。
• Pharmaceutical anthracene-2-carboxylic acid derivatives
  申请人：LILLY INDUSTRIES LIMITED

  公开号：EP0638540A1

  公开（公告）日：1995-02-15

  Pharmaceutical compounds as follows: 9,10-dihydro-9,10-dioxo-4,5,8-trimethoxyanthracene-2-carboxylic acid, 4,5-diethoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, 9,10-dihydro-9,10-dioxo-4,5-dipropoxyanthracene-2-carboxylic acid, 4,5-dibutoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid, 9,10-dihydro-5,8-dimethoxy-9,10-dioxoanthracene-2-carboxylic acid, 7-acetoxy-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid; and salts and esters thereof.

  药用化合物如下 9,10-二氢-9,10-二氧代-4,5,8-三甲氧基蒽-2-羧酸、 4,5-二乙氧基-9,10-二氢-9,10-二氧代蒽-2-羧酸、 9,10-二氢-9,10-二氧代-4,5-二丙氧基蒽-2-羧酸、 4,5-二丁氧基-9,10-二氢-9,10-二氧代蒽-2-羧酸 9,10-二氢-5,8-二甲氧基-9,10-二氧代蒽-2-羧酸、 7-乙酰氧基-9,10-二氢-9,10-二氧代蒽-2-羧酸； 及其盐类和酯类。
• US5430067A
  申请人：——

  公开号：US5430067A

  公开（公告）日：1995-07-04
• Anthraquinones related to rhein inhibit glucose uptake into chondrocytes. A mechanism for anti-osteoarthritis drugs?
  作者：Stephen L. Carney、Richard J. Broadmore、Rosemarie Tomlinson、Ann Kingston、Peter T. Gallagher、W.Martin Owton、Martin V. Miles、Michael Brunavs、Colin W. Smith、Terry A. Hicks、David R. Dobson、David J. Steggles、Samantha J. Ambler、Kelly A. Halliday

  DOI：10.1016/s0960-894x(97)00102-9

  日期：1997.1

  Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of anthraquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule. (C) 1997 Elsevier Science Ltd.