2-羟基丙烷-1,3-二基-二(二十二酸)酯 | 94201-62-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 2-羟基丙烷-1,3-二基-二(二十二酸)酯
• 英文名称: glyceryl dibehenate
• 英文别名: glyceryl 1,3-dibehenate；Compritol 888 CG ATO；1,3-bis-docosanoyloxy-propan-2-ol；2-hydroxypropane-1,3-diyl didocosanoate；glycerol dibehenate；(3-docosanoyloxy-2-hydroxypropyl) docosanoate
• CAS: 94201-62-4
• 化学式: C₄₇H₉₂O₅
• 分子量: 737.244
• InChiKey: GYNODFLZPXTEPN-UHFFFAOYSA-N

物化性质

• 熔点：
  42 °C
• 沸点：
  746.5±27.0 °C(Predicted)
• 密度：
  0.911±0.06 g/cm3(Predicted)
• LogP：
  20.073 (est)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  20.5
• 重原子数：
  52
• 可旋转键数：
  46
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  三醋精 、 俞酸甘油酯 在 sodium methylate 、 xylene 作用下， 生成 2-羟基丙烷-1,3-二基-二(二十二酸)酯
  参考文献：
  名称：

  Directed Interesterification in Glycerides. III. The Synthesis of Single-Fatty Acid 1,3-Diglycerides¹

  摘要：

  DOI：

  10.1021/ja01152a109

文献信息

• The use of a non-absorbable, non-digestible lipid for the treatment of hyperbilirubinemia
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1216625A1

  公开（公告）日：2002-06-26

  Described is the use of a non-absorbable, non-digestible lipid, for the manufacture of a pharmaceutical or dietary composition for the treatment of hyperbilirubinemia, specifically unconjugated hyperbilirubinemia such as neonatal jaundice, Crigler-Najjar syndrom and Gilbert syndrom.

  描述了一种不可吸收、不可消化脂质的用途，用于制造治疗高胆红素血症的药物或膳食组合物，特别是未结合型高胆红素血症，如新生儿黄疸、Crigler-Najjar 综合征和 Gilbert 综合征。
• Compositions with natural oils for providing a protective barrier
  申请人：L'OREAL

  公开号：US11039993B2

  公开（公告）日：2021-06-22

  A composition provides a protective barrier and includes glyceryl dibehenate, tribehenin, and glyceryl behenate, a surfactant that includes glyceryl stearate, hydrogenated vegetable oil, one or more additional fatty compounds, and one or more triglyceride. The composition optionally includes wax, a hydrating agent, and may be essentially free of or is devoid of one or more of petrolatum, mineral oil and water. The composition provides occlusivity and hydration effects that are comparable to compositions that include one or more of petrolatum, mineral oil and lanolin.

  一种可提供保护屏障的组合物，包括二盐酸甘油酯、三盐酸甘油酯和山嵛酸甘油酯，一种包括硬脂酸甘油酯、氢化植物油、一种或多种附加脂肪化合物和一种或多种甘油三酯的表面活性剂。组合物还可选择包括蜡、保湿剂，并且可以基本不含或不含一种或多种凡士林油、矿物油和水。该组合物提供的闭塞性和保湿效果与包含一种或多种凡士林油、矿物油和羊毛脂的组合物相当。
• Compositions for providing a protective barrier
  申请人：L'OREAL

  公开号：US11331254B2

  公开（公告）日：2022-05-17

  A composition provides a protective barrier and includes glyceryl dibehenate, tribehenin, and glyceryl behenate, a surfactant that includes glyceryl stearate, one or more fatty compounds, and one or more triglyceride. The composition optionally includes a hydrating agent and may be essentially free of or is devoid of one or more of petrolatum, mineral oil and water. The composition provides occlusivity and hydration effects that are comparable to compositions that include one or more of petrolatum, mineral oil and lanolin.

  一种可提供保护屏障的组合物，包括二盐酸甘油酯、三盐酸甘油酯和山嵛酸甘油酯，一种包括硬脂酸甘油酯、一种或多种脂肪化合物和一种或多种甘油三酯的表面活性剂。组合物可选择包括一种保湿剂，并且可以基本不含或不含一种或多种凡士林油、矿物油和水。该组合物提供的闭塞性和保湿效果可与包含一种或多种凡士林油、矿物油和羊毛脂的组合物相媲美。
• Reduced-calorie fats containing behenic acid and process for preparing same
  申请人：Council of Scientific & Industrial Research,

  公开号：US20040043125A1

  公开（公告）日：2004-03-04

  The invention relates to a reduced calorie fat and a process for the preparation of a reduced calorie fat, which includes esterification of edible oils with a source of behenic acid in the presence of a catalyst at a temperature in the range of about 25° C. to 150° C. for at least about 0.5 hours, and then recovering and purifying the reduced calorie fat using conventional methods.

  本发明涉及一种热量降低的脂肪和一种制备热量降低的脂肪的工艺，其中包括在催化剂存在下，在约25℃至150℃的温度范围内，将食用油与山嵛酸来源酯化至少约0.5小时，然后用常规方法回收和提纯热量降低的脂肪。
• [DE] DICARBONSÄUREESTERDERIVATE MIT EINEM DIACYLOXYPROPYLREST<br/>[EN] DICARBOXYLIC ACID ESTER DERIVATIVES WITH A DIACYLOXYPROPYL RESIDUE<br/>[FR] DERIVES D'ESTERS D'ACIDE DICARBOXYLIQUE COMPORTANT UN RESTE DIACYLOXYPROPYLE
  申请人：HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

  公开号：WO1996006823A1

  公开（公告）日：1996-03-07

  (DE) Es werden neue Dicarbonsäureesterderivate mit einem Diacyloxypropylrest mit den Formeln (I) oder (II) vorgeschlagen, in der R1 einen Poly-(C2-C3)-alkylenoxidrest mit 2 bis 20 Monomereinheiten oder einen Oligohydroxyalkylrest mit 2 bis 8 Kohlenstoffatomen und 1 bis 6 Hydroxygruppen, R2 und R3 gleich oder verschieden sind und einen geradkettigen oder verzweigten, gesättigten oder ungesättigten Alkylrest mit 8 bis 30 Kohlenstoffatomen, X für einen linearen oder verzweigten Alkylenrest mit 1 bis 6 Kohlenstoffatomen, der auch ungesättigt und Bestandteil eines Ringsystems sein kann, Sauerstoff, Schwefel, die Thionyl- oder Sulfonylgruppe, Y Sauerstoff oder eine Gruppe NR4, worin R4 für ein Wasserstoffatom, einen Alkylrest mit 1 bis 4 Kohlenstoffatomen oder eine Hydroxyalkylgruppe mit 2 bis 4 Kohlenstoffatomen steht, bedeuten. Die Verbindungen eignen sich als 'synthetic barrier lipids' zur Herstellung von Hautpflegemitteln.(EN) New dicarboxylic acid ester derivatives with a diacyloxypropyl residue have formulas (I) or (II), in which R1 stands for a poly-(C2-C3)-alkylene oxide residue with 2 to 20 monomer units or an oligohydroxyalkyl residue with 2 to 8 carbon atoms and 1 to 6 hydroxy groups; R2 and R3 are the same or different and stand for a straight- or branched-chain, saturated or unsaturated alkyl residue with 8 to 30 carbon atoms; X stands for a linear or branched alkylene residue with 1 to 6 carbon atoms, that may also be unsaturated and form part of a cyclic system, oxygen, sulphur, a thionyl or sulfonyl group,; Y stands for oxygen or a group NR4, in which R4 stands for a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms or a hydroxyalkyl group with 2 to 4 carbon atoms. These compounds are useful as synthetic barrier lipids in skin care products.(FR) De nouveaux dérivés d'esters d'acide dicarboxylique comportant un reste diacyloxypropyle répondent aux formules (I) ou (II), dans lesquelles R1 désigne un reste poly-(C2-C3)-alkylénoxyde avec 2 à 20 unités monomères ou un reste oligohydroxyalkyle avec 2 à 8 atomes de carbone et 1 à 6 groupes hydroxy; R2 et R3 sont identiques ou différents et désignent un reste alkyle saturé ou insaturé à chaîne droite ou ramifiée avec 8 à 30 atomes de carbone; X désigne un reste alkylène linéaire ou ramifié avec 1 à 6 atomes de carbone, qui peut également être insaturé et faire partie d'un système cyclique, oxygène, soufre, un groupe thionyle ou sulfonyle; Y désigne oxygène ou un groupe NR4, où R4 désigne un atome d'hydrogène, un reste alkyle avec 1 à 4 atomes de carbone ou un groupe hydroxyalkyle avec 2 à 4 atomes de carbone. Ces composés peuvent être utilisés comme lipides de barrière synthétiques dans des produits de soins de la peau.

  被提请的化学式为(DE)新 dicarbonsäureesterderivate mit einem Diacyloxypropylrest mit den Formeln (I) oder (II) proposed, in der R1 einen Poly-(C2-C3)-alkylenoxidrest mit 2 bis 20 Monomereinheiten oder einen Oligohydroxyalkylrest mit 2 bis 8 Kohlenstoffatomen und 1 bis 6 Hydroxygruppen, R2 und R3 gleich oder verschieden sind und einen geradkettigen oder verzweigten, gesättigten oder ungesättigten Alkylrest mit 8 bis 30 Kohlenstoffatomen, X für einen linearen oder verzweigten Alkylenrest mit 1 bis 6 Kohlenstoffatomen, der auch ungesättigt und Bestandteil eines Ringsystems sein kann, Sauerstoff, Schwefel, die Thionyl- oder Sulfonylgruppe, Y Sauerstoff oder eine Gruppe NR4, worin R4 für ein Wasserstoffatom, einen Alkylrest mit 1 bis 4 Kohlenstoffatomen oder eine Hydroxyalkylgruppe mit 2 bis 4 Kohlenstoffatomen steht, bedeuten. Die Verbindungen eignen sich als 'synthetic barrier lipids' zur Herstellung von Hautpflegemitteln.(formaler Text)(fr foll Irish Code(XEN.15.)/EN) New dicarboxylic acid ester derivatives with a diacyloxypropyl residue have formulas (I) or (II), in which R1 stands for a poly-(C2-C3)-alkylene oxide residue with 2 to 20 monomer units or an oligohydroxyalkyl residue with 2 to 8 carbon atoms and 1 to 6 hydroxy groups; R2 and R3 are the same or different and stand for a straight- or branched-chain, saturated or unsaturated alkyl residue with 8 to 30 carbon atoms; X stands for a linear or branched alkylene residue with 1 to 6 carbon atoms, that may also be unsaturated and form part of a cyclic system, oxygen, sulphur, a thionyl or sulfonyl group,; Y stands for oxygen or a group NR4, in which R4 stands for a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms or a hydroxyalkyl group with 2 to 4 carbon atoms. These compounds are useful as synthetic barrier lipids in skin care products.(EN) New dicarboxylic acid ester derivatives with a diacyloxypropyl residue have formulas (I) or (II), in which R1 stands for a poly-(C2-C3)-alkylene oxide residue with 2 to 20 monomer units or an oligohydroxyalkyl residue with 2 to 8 carbon atoms and 1 to 6 hydroxy groups; R2 and R3 are the same or different and stand for a straight- or branched-chain, saturated or unsaturated alkyl residue with 8 to 30 carbon atoms; X stands for a linear or branched alkylene residue with 1 to 6 carbon atoms, that may also be unsaturated and form part of a cyclic system, oxygen, sulphur, a thionyl or sulfonyl group,; Y stands for oxygen or a group NR4, in which R4 stands for a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms or a hydroxyalkyl group with 2 to 4 carbon atoms. These compounds are useful as synthetic barrier lipids in skin care products.(EN) New dicarboxylic acid ester derivatives with a diacyloxypropyl residue have formulas (I) or (II), in which R1 stands for a poly-(C2-C3)-alkylene oxide residue with 2 to 20 monomer units or an oligohydroxyalkyl residue with 2 to 8 carbon atoms and 1 to 6 hydroxy groups; R2 and R3 are the same or different and stand for a straight- or branched-chain, saturated or unsaturated alkyl residue with 8 to 30 carbon atoms; X stands for a linear or branched alkylene residue with 1 to 6 carbon atoms, that may also be unsaturated and form part of a cyclic system, oxygen, sulphur, a thionyl or sulfonyl group,; Y stands for oxygen or a group NR4, in which R4 stands for a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms or a hydroxyalkyl group with 2 to 4 carbon atoms. These compounds are useful as synthetic barrier lipids in skin care products. Die Verbindungen eignen sich als 'synthetic barrier lipids' zur Herstellung von Hautpflegemitteln. (formaler Text) Die Verbindungen eignen sich als 'synthetic barrier lipids' zur Herstellung von Hautpflegemitteln.