hexahydrotyrosine | 4441-51-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: hexahydrotyrosine
• 英文别名: (S)-2-amino-3-(4-hydroxy-cyclohexyl)-propionic acid；(S)-2-Amino-3-(4-hydroxy-cyclohexyl)-propionsaeure；(s)-2-Amino-3-(4-hydroxycyclohexyl)propanoic acid；(2S)-2-amino-3-(4-hydroxycyclohexyl)propanoic acid
• CAS: 4441-51-4
• 化学式: C₉H₁₇NO₃
• 分子量: 187.239
• InChiKey: HUGAWXCWXHSPBW-RRQHEKLDSA-N

物化性质

• 沸点：
  365.8±17.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  hexahydrotyrosine 生成 4-(2-氨乙基)环己醇
  参考文献：
  名称：

  Waser; Fauser, Helvetica Chimica Acta, 1927, vol. 10, p. 264

  摘要：

  DOI：
• 作为产物：
  描述：

  L-酪氨酸 在 铂 作用下， 生成 hexahydrotyrosine 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Waser; Brauchli, Helvetica Chimica Acta, 1923, vol. 6, p. 205

  摘要：

  DOI：

文献信息

• Ruthenium-catalyzed hydrogenation of aromatic amino acids in aqueous solution
  作者：Bing Sun、Georg Süss-Fink

  DOI：10.1016/j.jorganchem.2015.09.011

  日期：2016.6

  containing metallic ruthenium nanoparticles intercalated in hectorite (nano[email protected]) was found to catalyze the hydrogenation of aromatic amino acids in aqueous solution. Thus, l-phenylalanine and l-phenylglycine can be converted exclusively into the corresponding l-cyclohexyl amino acids with retention of chirality under mild conditions (60 °C, 40 bar), conversion and selectivity being superior to

  发现包含嵌入锂蒙脱石中的金属钌纳米颗粒的催化剂（纳米[受电子邮件保护]）可催化水溶液中芳族氨基酸的氢化。因此，升-苯丙氨酸和升-苯基甘氨酸可以专门转化成相应的升-环己基氨基磺酸与温和的条件（60℃，40巴），转化率和选择性优于99％下的手性的保持。催化剂可以循环使用至少三次，而不会损失活性和选择性。
• Multicyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
  申请人：——

  公开号：US20030134874A1

  公开（公告）日：2003-07-17

  Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

  本发明揭示了一种与VLA-4结合的化合物。其中某些化合物还能抑制白细胞粘附，特别是VLA-4介导的白细胞粘附。这样的化合物可用于治疗哺乳动物患者（例如人类）的炎症性疾病，如哮喘、阿尔茨海默病、动脉硬化、艾滋病痴呆、糖尿病、炎症性肠病、类风湿性关节炎、组织移植、肿瘤转移和心肌缺血。这些化合物也可用于治疗多发性硬化等炎症性脑疾病。
• Polymeric conjugates for tissue activated drug delivery
  申请人：——

  公开号：US20040228831A1

  公开（公告）日：2004-11-18

  The present invention relates to a polymeric drug conjugate with one or more biologically active agents conjugated via an enzymatically cleavable linker to either a regular repeating linear unit comprising a water soluble polymer segment and a multifunctional chemical moiety, or a branched polymer comprising two or more water soluble polymer segments each bound to a common multifunctional chemical moiety, as well as to methods of making such conjugates. The present invention is also directed to pharmaceutical compositions comprising such conjugates and to the use of such conjugates to treat pathological conditions.

  本发明涉及一种聚合物药物结合物，其通过酶可降解的连接物将一种或多种生物活性剂与具有水溶性聚合物段和多功能化学基团的常规重复线性单元或包含两个或多个水溶性聚合物段，每个聚合物段都与一个共同的多功能化学基团结合的支化聚合物结合，以及制备这种结合物的方法。本发明还涉及包含这种结合物的制药组合物以及使用这种结合物治疗病理状况的方法。
• Methods and reagents for improved cell-based assays
  申请人：——

  公开号：US20030077569A1

  公开（公告）日：2003-04-24

  The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more particularly to improved reagents for use in cell-based assays, especially those using fluorogenic substrates.

  长期以来，人们一直希望能够有效地确定细胞中酶的表达状态，以此作为诊断疾病的材料。本发明涉及细胞酶学，更具体地说，涉及用于细胞检测的改良试剂，特别是那些使用荧光底物的试剂。
• Method and apparatus for increasing the dynamic range and accuracy of binding assays
  申请人：——

  公开号：US20030078737A1

  公开（公告）日：2003-04-24

  This invention relates to methods for increasing the dynamic range and accuracy of assays in which the presence, absence, activity or concentration of a target analyte is assayed by the emission or quenching of a light signal, or by a change (i.e., an evolution or loss) of a light signal in two or more time intervals. In preferred embodiments multiple digitized images are captured at varying times, and the images analyzed to identify captured images within the dynamic range of the assay. The invention further relates to apparati capable of implementing such methods.

  本发明涉及提高化验动态范围和准确性的方法，其中目标分析物的存在、不存在、活性或浓度是通过光信号的发射或淬灭，或通过光信号在两个或多个时间间隔内的变化（即演变或损失）来化验的。 在优选的实施方案中，在不同的时间捕获多个数字化图像，并对图像进行分析，以确定在检测动态范围内捕获的图像。 本发明还涉及能够实施此类方法的仪器。