We describe Cu-catalyzed intermolecular alkynylation and allylation of unactivated C(sp3)–H bonds with singly occupied molecular orbital-philes (SOMO-philes) via hydrogen atom transfer (HAT). Employing N-fluoro-sulfonamide as a HAT reagent, a set of substituted alkene and alkyne compounds were synthesized in high yields with good regioselectivity and functional-group compatibility. Late-stage functionalization
hydroacylation of α-substituted α,β-unsaturated carbonyl compoundsthrough direct hydrogen atom transfer in the presence of the photocatalyst anthraquinone and chiral N,N′-dioxide/metal complexes. This mild, robust method provided a facile access to a wide array of chiral ketones with α-tertiary stereocenters by using the readily available aldehyde as a hydroacylation reagent. Based on the spectroscopy experiments
Hexamethylenetetramine/acetic anhydride-promoted alpha-methylenation of aryl alkyl ketones followed by acid-catalyzed cyclization of the resulting acrylophenones produce 2-alkyl indanones in excellent yields.