pleuromutilin

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pleuromutilin
• 英文别名: Pleuromulin, Antibiotic for Culture Media Use Only；[(1S,2R,3S,4S,6R,7R,8R,12R)-4-ethenyl-3-hydroxy-2,4,7,12-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-hydroxyacetate
• 化学式: C₂₂H₃₄O₅
• 分子量: 378.509
• InChiKey: YSBXUHAJXRCCET-BKUNHTPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  pleuromutilin 在 4-二甲氨基吡啶 、 N-碘代丁二酰亚胺 、 hydroquinidine 1,4-phthalazinediyl diether 、 silver fluoride 、 三乙胺 、 cesium fluoride 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 4.08h， 生成
  参考文献：
  名称：

  银介导的烯烃分子间碘三氟甲氧基化。

  摘要：

  首次探索了以AgF为催化剂，TFMS为三氟甲氧基化试剂的烯烃与NIS之间的分子间碘三氟甲氧基化反应。实用的工艺，良好的官能团耐受性和易于扩展的性能使该反应成为合成三氟甲氧基化碘化物的诱人方法，可轻松用于进一步的合成操作。

  DOI：

  10.1021/acs.joc.9b03206

文献信息

• Pleuromutilin hippuric acid ester with antibacterial activity and a method of preparing the same
  申请人：Yang Dan

  公开号：US11117859B1

  公开（公告）日：2021-09-14

  A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

  公开了具有抗药物耐药细菌活性的化合物，其具有以下化学式(I)。还公开了制备化合物的方法。
• PLEUROMULIN LIPOIC ACID ESTER WITH ANTIBACTERIAL ACTIVITY AND A METHOD OF PREPARING THE SAME
  申请人：ZHAO Qianqian

  公开号：US20220194918A1

  公开（公告）日：2022-06-23

  A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
• [EN] DELIVERY SYSTEM TO TARGET GRAM-NEGATIVE BACTERIA<br/>[FR] SYSTÈME DE DISTRIBUTION POUR CIBLER DES BACTÉRIES À GRAM NÉGATIF
  申请人：[en]THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

  公开号：WO2023200824A1

  公开（公告）日：2023-10-19

  Disclosed herein are compounds of the formulas (I) as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to contact Gram-negative bacteria. Also provided are methods of administering compounds and compositions provided herein to a patient in need thereof, for example, for the treatment or prevention of bacterial infections or diseases.
• Silver-Mediated Intermolecular Iodotrifluoromethoxylation of Alkenes
  作者：Qingyun Huang、Pingping Tang

  DOI：10.1021/acs.joc.9b03206

  日期：2020.2.21

  For the first time, intermolecular iodotrifluoromethoxylation between alkenes and NIS with AgF as the catalyst and TFMS as the trifluoromethoxylation reagent has been explored. The practical processes, good functional group tolerance, and easy scalability make this reaction an attractive protocol for the synthesis of trifluoromethoxylated iodides, which can be readily used for further synthetic manipulation

  首次探索了以AgF为催化剂，TFMS为三氟甲氧基化试剂的烯烃与NIS之间的分子间碘三氟甲氧基化反应。实用的工艺，良好的官能团耐受性和易于扩展的性能使该反应成为合成三氟甲氧基化碘化物的诱人方法，可轻松用于进一步的合成操作。