9-carbazolylacetone | 15375-57-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-carbazolylacetone
• 英文别名: 1-(9H-carbazol-9-yl)acetone；1-(9H-Carbazol-9-yl)-2-propanone；1-carbazol-9-ylpropan-2-one
• CAS: 15375-57-2
• 化学式: C₁₅H₁₃NO
• mdl: MFCD12061706
• 分子量: 223.274
• InChiKey: YRNYZFRCUHGWHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  9-(2-Acetoxyprop-1-enyl)carbazole 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 20.5h， 以89%的产率得到9-carbazolylacetone
  参考文献：
  名称：

  Anfinogenov; Zuikova; Khlebnikov, Russian Journal of Organic Chemistry, 2000, vol. 36, # 9, p. 1335 - 1337

  摘要：

  DOI：

文献信息

• [EN] CELL CULTURE SUBSTRATES<br/>[FR] SUBSTRATS DE CULTURE CELLULAIRE
  申请人：UNIV MACQUARIE

  公开号：WO2019033171A1

  公开（公告）日：2019-02-21

  The present application describes a class of peptides comprising from (2) to (12) amino acid residues, wherein: the N-terminus of the peptide is linked to an optionally substituted, fused polycyclic group comprising an aromatic ring; at least one amino acid residue has a hydrophobic side chain; at least two amino acid residues have a cation-containing side chain, or at least one amino acid residue has two or more cation-containing side chains, or at least one amino acid residue has one or more side chains comprising two or more cations; and the net charge of the peptide is positive at a pH of from about (4) to about (10). The present application also describes hydrogels and cell culture substrates comprising the peptides, as well as the use of the cell culture substrates for culturing cells.

  本申请描述了一类肽，包括（2）到（12）个氨基酸残基，其中：肽的N-末端与一个可选择替代的、融合的多环芳香环团相连；至少一个氨基酸残基具有疏水侧链；至少两个氨基酸残基具有含阳离子的侧链，或者至少一个氨基酸残基具有两个或更多含阳离子的侧链，或者至少一个氨基酸残基具有一个或多个含有两个或更多阳离子的侧链；并且在约为（4）到约为（10）的pH下，肽的净电荷为正。本申请还描述了包含这些肽的水凝胶和细胞培养基质，以及利用细胞培养基质培养细胞的用途。
• 3-Aminocarbozole compound, pharmaceutical composition containing it and preparation method therefor
  申请人：Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.

  公开号：EP2119705A1

  公开（公告）日：2009-11-18

  The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.

  本发明涉及3-氨基咔唑的新型苯甲酰衍生物，包含它们的药物组合物，制备它们的方法以及利用这些化合物生产对与前列腺素E2（PGE2）的产生相关的干扰的治疗或预防有用的药物，例如炎症过程、疼痛、发热、肿瘤、阿尔茨海默病和动脉粥样硬化。
• 3-AMINOCARBAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING IT AND PREPARATION METHOD THEREFOR
  申请人：Alisi Maria Alessandra

  公开号：US20110060025A1

  公开（公告）日：2011-03-10

  The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E 2 (PGE 2 ), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.

  本发明涉及新型3-氨基咔唑的苯甲酰衍生物，以及包含它们的药物组合物、制备它们的方法，以及使用这些化合物生产用于治疗或预防与前列腺素E2（PGE2）产生相关的疾病的药物，例如炎症过程、疼痛、发热、肿瘤、阿尔茨海默病和动脉粥样硬化。
• 3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor
  申请人：AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F S.p.A.

  公开号：US10005730B2

  公开（公告）日：2018-06-26

  The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.

  本发明涉及 3-氨基咔唑的新型苯甲酰衍生物、含有这些衍生物的药物组合物、制备这些衍生物的方法以及使用这些化合物生产一种药物，这种药物可用于治疗或预防与前列腺素 E2（PGE2）的产生有关的紊乱，例如炎症过程、疼痛、发热、肿瘤、老年痴呆症和动脉粥样硬化。
• US8637682B2
  申请人：——

  公开号：US8637682B2

  公开（公告）日：2014-01-28