N-乙氧羰基苯妥英 | 1097-57-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: N-乙氧羰基苯妥英
• 中文别名: N-苯妥英碳水化合物
• 英文名称: ethyl 3-(5,5-diphenylhydantoin) formate
• 英文别名: ethyl 5,5-diphenyl-3-hydantoin formate；2,5-dioxo-4,4-diphenyl-imidazolidine-1-carboxylic acid ethyl ester；N³-Ethoxycarbonyl-5,5-diphenyl-hydantoin；5,5-Diphenyl-hydantoin-3-carbonsaeure-ethylester；N³-Carbethoxy-5,5-diphenyl-hydantoin；3-Aethoxycarbonyl-5,5-diphenyl-hydantoin；1-Imidazolidinecarboxylic acid, 2,5-dioxo-4,4-diphenyl-, ethyl ester；ethyl 2,5-dioxo-4,4-diphenylimidazolidine-1-carboxylate
• CAS: 1097-57-0
• 化学式: C₁₈H₁₆N₂O₄
• 分子量: 324.336
• InChiKey: WAOIWRAOVPQJKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  N-乙氧羰基苯妥英 在 一水合肼 作用下， 以 乙醇 为溶剂， 以100%的产率得到苯妥英
  参考文献：
  名称：

  Kiec-Kononowicz, Katarzyna; Zejc, Alfred; Byrtus, Hanna, Polish Journal of Chemistry, 1984, vol. 58, # 4/5/6, p. 585 - 591

  摘要：

  DOI：

文献信息

• Diphenylhydantoin derivatives
  申请人：Miles Laboratories, Inc.

  公开号：US04194048A1

  公开（公告）日：1980-03-18

  Reagents for use in binding assays, particularly immuno-assays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including .beta.-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N.sup.1, N.sup.3 and .omicron.-phenyl derivatives of diphenylhydantoin for preparing same. N.sup.1 and N.sup.3 -.omega.-aminoalkyl and .omicron.-(.omega.-aminoalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to a .beta.-galactosyl-umbelliferone derivative to form labeled conjugates useful in homogeneous or heterogeneous binding assays. N.sup.1 and N.sup.3 -.omega.-carboxyalkyl and .omicron.-(.omega.-carboxyalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to an immunogenic polyamino acid to form immunogen conjugates against which diphenylhydantoin-specific antibodies can be raised.

  用于结合测定，特别是免疫测定，以确定苯妥英，并用于制备在这些测定中使用的试剂，包括β-半乳糖苯妥英缩合物，苯妥英免疫原，苯妥英的N1、N3和ω-苯基衍生物，用于制备相同的试剂。通过酰胺键偶联制备N1和N3-ω-氨基烷基和ω-(ω-氨基烷氧基)-苯基衍生物，以形成标记的缩合物，可用于均相或非均相结合测定。通过酰胺键偶联制备N1和N3-ω-羧基烷基和ω-(ω-羧基烷氧基)-苯基衍生物，以与免疫原多氨基酸偶联形成免疫原缩合物，可产生针对苯妥英特异性抗体。
• Reagents for use in binding assays to determine diphenylhydantoin
  申请人：Miles Laboratories, Inc.

  公开号：US04182856A1

  公开（公告）日：1980-01-08

  Reagents for use in binding assays, particularly immunoassays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including .beta.-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N.sup.1, N.sup.3 and o-phenyl derivatives of diphenylhydantoin for preparing same. N.sup.1 and N.sup.3 -.omega.-aminoalkyl and o-(.omega.-aminoalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to a .beta.-galactosyl-umbelliferone derivative to form labeled conjugates useful in homogeneous or heterogeneous binding assays. N.sup.1 and N.sup.3 -.omega.-carboxyalkyl and o-(.omega.-carboxyalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to an immunogenic polyamino acid to form immunogen conjugates against which diphenylhydantoin-specific antibodies can be raised.

  用于结合测定的试剂，特别是免疫测定，以确定二苯并咪唑和用于制备此类试剂的试剂，包括β-半乳糖苷基-香豆素-二苯并咪唑共轭物、二苯并咪唑免疫原和用于制备同样物的二苯并咪唑的N1、N3和o-苯基衍生物。 N1和N3-.ω-氨基烷基和o-（ω-氨基烷氧基）-苯基衍生物通过酰胺键耦合到β-半乳糖苷基-香豆素衍生物上，形成标记的共轭物，可用于均相或异相结合测定。 N1和N3-.ω-羧基烷基和o-（ω-羧基烷氧基）-苯基衍生物通过酰胺键耦合到免疫原性多氨基酸上，形成免疫原共轭物，可以产生针对二苯并咪唑特异性抗体。
• Diphenylhydantoin immunogen conjugates
  申请人：Miles Laboratories, Inc.

  公开号：US04213894A1

  公开（公告）日：1980-07-22

  Reagents for use in binding assays, particularly immunoassays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including .beta.-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N.sup.1, N.sup.3 and o-phenyl derivatives of diphenylhydantoin for preparing same. N.sup.1 and N.sup.3 -.omega.-aminoalkyl and o-(.omega.-aminoalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to a .beta.-galactosyl-umbelliferone derivative to form labeled conjugates useful in homogeneous or heterogeneous binding assays. N.sup.1 and N.sup.3 -.omega.-carboxyalkyl and o-(.omega.-carboxyalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to an immunogenic polyamino acid to form immunogen conjugates against which diphenylhydantoin-specific antibodies can be raised.

  用于结合测定的试剂，特别是免疫测定，以确定二苯并噻嗪，并用于制备用于这种测定的试剂，包括β-半乳糖苷基-芹菜素-二苯并噻嗪共轭物，二苯并噻嗪免疫原和二苯并噻嗪的N1、N3和o-苯基衍生物，用于制备同类或异类结合测定的标记共轭物。N1和N3-ω-氨基烷基和o-(ω-氨基烷氧基)-苯基衍生物通过酰胺键偶联到β-半乳糖苷基-芹菜素衍生物上形成标记共轭物，可用于同质或异质结合测定。N1和N3-ω-羧基烷基和o-(ω-羧基烷氧基)-苯基衍生物通过酰胺键偶联到免疫原多氨基酸上形成免疫原共轭物，可制备出针对二苯并噻嗪特异性抗体的免疫原共轭物。
• Diphenylhydantoin antibodies
  申请人：Miles Laboratories, Inc.

  公开号：US04213964A1

  公开（公告）日：1980-07-22

  Reagents for use in binding assays, particularly immuno assays, to determine diphenylhydantoin and for preparing reagents employed in such assays, including .beta.-galactosyl-umbelliferone-diphenylhydantoin conjugates, diphenylhydantoin immunogens, and N.sup.1, N.sup.3 and .omicron.-phenyl derivatives of diphenylhydantoin for preparing same. N.sup.1 and N.sup.3 -.omega.-aminoalkyl and .omicron.-(.omega.-aminoalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to a .beta.-galactosyl-umbelliferone derivative to form labeled conjugates useful in homogeneous or heterogeneous binding assays. N.sup.1 and N.sup.3 -.omega.-carboxyalkyl and .omicron.-(.omega.-carboxyalkoxy)-phenyl derivatives are prepared and coupled by amide linkage to an immunogenic polyamino acid to form immunogen conjugates against which diphenylhydantoin-specific antibodies can be raised.

  用于结合测定的试剂，特别是免疫测定，以确定二苯并咪唑酮，用于制备在这种测定中使用的试剂，包括β-半乳糖苷基-炔酰基-二苯并咪唑酮共轭物，二苯并咪唑酮免疫原和用于制备相同的N1，N3和ω-苯基衍生物。 N1和N3-ω-氨基烷基和ω-（ω-氨基烷氧基）-苯基衍生物通过酰胺键偶联到β-半乳糖苷基-炔酰基-炔酰基-炔酰基衍生物上，形成标记的共轭物，可用于均相或异相结合测定。 N1和N3-ω-羧基烷基和ω-（ω-羧基烷氧基）-苯基衍生物通过酰胺键偶联到免疫原多氨基酸上，形成免疫原共轭物，可以引起二苯并咪唑酮特异性抗体。
• Oligomer-Containing Hydantoin Compounds
  申请人：Riggs-Sauthier Jennifer

  公开号：US20140039020A1

  公开（公告）日：2014-02-06

  The invention relates to (among other things) oligomer-containing hydantoin compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.

  本发明涉及含寡聚物的脲嘧啶化合物（除其他外）。本发明的一种化合物，在通过任何一种给药途径给予时，表现出比缺乏寡聚物的相应化合物更多的优点。