4-bromo-3,5-diphenylisothiazole | 942227-99-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 4-bromo-3,5-diphenylisothiazole
• 英文别名: 4-Bromo-3,5-diphenyl-1,2-thiazole
• CAS: 942227-99-8
• 化学式: C₁₅H₁₀BrNS
• 分子量: 316.221
• InChiKey: COYWQWCOISSHEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromo-3,5-diphenylisothiazole 在 肼 作用下， 反应 2.5h， 以100%的产率得到3,5-二苯基异噻唑
  参考文献：
  名称：

  The conversion of isothiazoles into pyrazoles using hydrazine

  摘要：

  The conversion of isothiazoles into pyrazoles on treatment with hydrazine is investigated. The influence of various C-3, C-4 and C-5 isothiazole substituents and some limitations of this ring transformation are examined. When the isothiazole C-3 substituent is a good nucleofuge, 3-aminopyrazoles are obtained. However, when the 3-substituent is not a leaving group it is retained in the pyrazole product. Treatment of 4-bromo-3-chloro-5-phenylisothiazoie 56 or 3-chloro-4,5-diphenylisothiazole 57 with anhydrous hydrazine at ca. 200 degrees C for a few minutes gives the corresponding 3-hydrazinoisothiazoles 61 and 64 respectively in high yields; the stability of these new hydrazines is investigated. 5,5'-Diphenyl-3,3'-biisothiazole-4,4'-dicarbonitrile 78 reacts with hydrazine to give 5,5'-diphenyl-3,3'-bi(1H-pyi-azole)-4,4'-dicarbonitrile 79. Methylhydrazine reacts with 3-chloro-5-phenytisothiazole-4-carbonitrile 1 to give 3-(1-methylhydrazino)-5-phenylisothiazole-4-carbontrile 83 and 3-amino-lmethyl-5-phenylpyrazole-4-carbonitrile 84. All products are fully characterised and rational mechanisms for the isothiazole into pyrazole transformation are proposed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.041
• 作为产物：
  描述：

  3,5-二苯基异噻唑 在 N-溴代丁二酰亚胺(NBS) 、 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 69.0h， 以97%的产率得到4-bromo-3,5-diphenylisothiazole
  参考文献：
  名称：

  炔肟肟醚的脱甲氧基环加成反应合成异戊烯唑和异噻唑

  摘要：

  通过使用廉价且无活性的硒粉和Na 2 S作为硒和硫源，通过炔基肟醚的碱促进的脱甲氧基环加成反应，已开发出合成异硒唑和异噻唑的一般方法。这种转变的特点是通过在具有良好官能团耐受性的一锅反应中形成N-Se / S和C-Se / S键，直接构建含N，Se和S的杂环。

  DOI：

  10.1021/acs.joc.0c02286

文献信息

• Transition Metal‐Free Synthesis of Substituted Isothiazoles <i>via</i> Three‐Component Annulation of Alkynones, Xanthate and NH ₄ I
  作者：Jian Li、Jiaming Li、Xiaoliang Ji、Qiang Liu、Lu Chen、Yubing Huang、Yibiao Li

  DOI：10.1002/adsc.202001179

  日期：2021.2.16

  A protocol was described to access diverse isothiazoles with functionalization potential via transition metal‐free three‐component annulation of alkynones, potassium ethylxanthate (EtOCS2K) and ammonium iodide (NH4I). A sequential regioselective hydroamination/thiocarbonylation/intramolecular cyclization cascade achieved the efficient formation of consecutive C−N, C−S and N−S bonds in a one‐pot process

  已描述了通过炔烃，乙基黄原酸钾（EtOCS 2 K）和碘化铵（NH 4 I）的无过渡金属三组分环化获得具有功能化潜力的各种异噻唑的方案。连续的区域选择性加氢胺化/硫代羰基化/分子内环化级联可在一个锅法中有效地形成连续的CN，CS和NS键。
• 3,4,5-Triarylisothiazoles via C–C coupling chemistry
  作者：Irene C. Christoforou、Panayiotis A. Koutentis

  DOI：10.1039/b702154b

  日期：——

  The regiocontrolled preparation of triarylisothiazoles is presented. 3-Halo-5-phenylisothiazole-4-carbonitriles, 1 (hal = Cl) and 18 (hal = I), are converted into the corresponding 4-bromo derivatives 5 (3-hal = Cl) and 24 (3-hal = I) via a Hunsdiecker strategy while the 4-iodo analogues 7 (3-hal = Cl) and 22 (3-hal = I) are prepared via a Hoffmann and Sandmeyer strategy. Regioselective Suzuki, Stille and Negishi reactions occur at C-4 with both the 4-bromo- and 4-iodoisothiazoles 5 and 7, the latter being more reactive than the former. 3-Iodoisothiazoles 22 and 24 fail to give regiocontrolled Suzuki, Stille or Negishi couplings, however, 4-bromo-3-iodo-5-phenylisothiazole24 gives the regiospecific palladium catalysed Ullmann-type reaction product 3,3′-bi(4-bromo-5-phenylisothiazole)25. Alkali hydrolysis of 3-chloro-4,5-diphenylisothiazole8 gives the 3-hydroxy analogue 12 which is converted into 3-bromo-4,5-diphenylisothiazole13 with POBr3. 3-Bromoisothiazole13 reacts with phenylzinc chloride to give 3,4,5-triphenylisothiazole17 but fails to undergo effective Suzuki or Stille couplings. 3,5-Diphenylisothiazole-4-carbonitrile26 is converted into the 4-bromo- and 4-iodo-3,5-diphenylisothiazoles 30 and 34 both of which are effective for Suzuki and Stille couplings. A series of triarylisothiazoles are prepared in this manner and fully characterised.

  本文介绍了三芳基异噻唑的区域控制制备方法。3-卤-5-苯基异噻唑-4-氰化物（1（卤=Cl）和18（卤=I））通过Hunsdiecker策略转化为相应的4-溴衍生物（5（3-卤=Cl）和24（3-卤=I）），而4-碘类似物（7（3-卤=Cl）和22（3-卤=I））则通过Hoffmann和Sandmeyer策略制备。区域选择性的Suzuki、Stille和Negishi反应在C-4位进行，无论是4-溴还是4-碘异噻唑（5和7），后者比前者更具反应活性。然而，3-碘异噻唑（22和24）未能给出区域控制的Suzuki、Stille或Negishi耦合反应，但4-溴-3-碘-5-苯基异噻唑24给出了区域特异性的钯催化Ullmann型反应产物3,3′-双（4-溴-5-苯基异噻唑）25。3-氯-4,5-二苯基异噻唑8的碱水解得到3-羟基类似物12，该物质与POBr3反应转化为3-溴-4,5-二苯基异噻唑13。3-溴异噻唑13与苯基锌氯反应得到3,4,5-三苯基异噻唑17，但未能进行有效的Suzuki或Stille耦合反应。3,5-二苯基异噻唑-4-氰化物26转化为4-溴和4-碘-3,5-二苯基异噻唑30和34，两者均能有效进行Suzuki和Stille耦合反应。通过这种方法制备了一系列三芳基异噻唑并进行了完全表征。