3,4-bis(4-methoxyphenyl)-6-chloropyridazine | 67820-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,4-bis(4-methoxyphenyl)-6-chloropyridazine
• 英文别名: 6-chloro-3,4-bis-(4-methoxy-phenyl)-pyridazine；5,6-bis(p-methoxyphenyl)-3-chloropyridazine；6-chloro-3,4-bis(4-methoxyphenyl)pyridazine
• CAS: 67820-94-4
• 化学式: C₁₈H₁₅ClN₂O₂
• 分子量: 326.782
• InChiKey: SIPRWRSULNBGBS-UHFFFAOYSA-N

物化性质

• 沸点：
  491.5±45.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4-bis(4-methoxyphenyl)-6-chloropyridazine 以35%的产率得到
  参考文献：
  名称：

  NANNINI G.; BIASOII G.; PERRONE E.; FORGIONE A.; BUTTINONI A.; FERRARI M., EUR. J. MED. CHEM. CHIM. THER., 1979, 14, NO 1, 53-60

  摘要：

  DOI：
• 作为产物：
  描述：

  5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one 在 三氯氧磷 作用下， 反应 3.0h， 以81.6%的产率得到3,4-bis(4-methoxyphenyl)-6-chloropyridazine
  参考文献：
  名称：

  Mono- and Di-substituted 5,6-Diphenyl-3-alkylaminopyridazines Active as ACAT Inhibitors

  摘要：

  A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acylCoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.

  DOI：

  10.3987/com-01-9351

文献信息

• Phenylpyridazine compounds and medicines containing the same
  申请人：Kowa Co., Ltd.

  公开号：US06664256B1

  公开（公告）日：2003-12-16

  Phenylpyridazine compounds represented by the following formula (I): are provided, wherein R1, R2, R3, R4, and n are as defined herein having excellent inhibitory activity against interleukin-1&bgr; production, and useful in the treatment of prevention of diseases caused by stimulation of interleukin-1&bgr; production, such as immune system diseases, inflammatory diseases, and ischemic diseases.

  以下公式（I）所代表的苯基吡啶化合物提供，其中R1、R2、R3、R4和n如本文所定义，具有出色的抑制性活性，可用于治疗或预防由白细胞介素-1β产生刺激引起的疾病，如免疫系统疾病、炎症性疾病和缺血性疾病。
• Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates
  申请人：American Cyanamid Company

  公开号：US04092311A1

  公开（公告）日：1978-05-30

  This disclosure describes novel alkyl 3-[6-(aryl)-3-pyridazinyl]-carbazates useful as hypotensive agents in mammals. SP CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of our copending application Ser. No. 692,254, filed June 3, 1976 now abandoned, which in turn is a continuation-in-part of our abandoned application Ser. No. 552,024, filed Feb. 24, 1975 now abandoned.

  本公开描述了一种新的烷基3-[6-(芳基)-3-吡啶并嗪基]-氨基甲酸酯，可用作哺乳动物的降压剂。SP与相关申请的交叉引用 本申请是我们待决申请Ser. No. 692,254的延续申请，该待决申请于1976年6月3日提交，现已废弃，而该待决申请又是我们废弃申请Ser. No. 552,024的部分延续申请，该废弃申请于1975年2月24日提交，现已废弃。
• PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：Kowa Co., Ltd.

  公开号：EP1300399B1

  公开（公告）日：2007-08-22
• Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1β) production
  作者：Takayuki Matsuda、Taro Aoki、Tadaaki Ohgiya、Tomoyuki Koshi、Masao Ohkuchi、Hiromichi Shigyo

  DOI：10.1016/s0960-894x(01)00432-2

  日期：2001.9

  New pyridazine derivatives were prepared, and their abilities to inhibit IL-1 beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described. (C) 2001 Elsevier Science Ltd. All rights reserved.
• US4092311A
  申请人：——

  公开号：US4092311A

  公开（公告）日：1978-05-30