4'-(N-2-hydroxyethyl-N-methylamino)-2,2':6',2''-terpyridine | 193945-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4'-(N-2-hydroxyethyl-N-methylamino)-2,2':6',2''-terpyridine
• 英文别名: 2-(methvl-r2,2';6'2"lterpvridine-4'yl-amino)-ethanol；2-(methyl-[2,2';6',2'']terpyrid-4'-ylamino)ethanol；2-(Methyl-[2,2';6'2'']terpyridine-4'yl-amino)-ethanol；2-[(2,6-dipyridin-2-ylpyridin-4-yl)-methylamino]ethanol
• CAS: 193945-29-8
• 化学式: C₁₈H₁₈N₄O
• 分子量: 306.367
• InChiKey: NYUGZPSNSKHMGS-UHFFFAOYSA-N

物化性质

• 沸点：
  547.3±50.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  manganese(II) chloride tetrahydrate 、 4'-(N-2-hydroxyethyl-N-methylamino)-2,2':6',2''-terpyridine 以 乙醇 为溶剂， 以92%的产率得到
  参考文献：
  名称：

  Novel terpyridine-manganese(II) complexes and their potential to activate hydrogen peroxide

  摘要：

  The ability of manganese(II) complexes with substituted terpyridine (terpy) ligands to activate hydrogen peroxide and to catalyze oxidation of the substrates Morin and Trolox C was studied in aqueous alkaline solution. Introduction of pi-donor substituents as hydroxy or amine groups in the 4-positions of the pyridine rings resulted in an enhanced catalytic activity compared to the unsubstituted terpyridine-manganese(II) complex. However, the catalytic activity depends critically on the substitution pattern. Differences in the activity of catalysts towards Morin and Trolox C are discussed with respect to the mechanism of oxidation. Dissolution of isolated complexes with a ligand-to-manganese ratio of 1: 1 in aqueous buffer results in formation of a mixture of 1:1 and 2:1 species. The 1:1 species was found to be the catalytically more active precursor, suggesting that free coordination sites are important for a high catalytic activity. Activity was found to be pH dependent and was highest at pH similar to10. All complexes also catalyze the disproportionation of hydrogen peroxide into oxygen and water. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s1381-1169(03)00406-0
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 4'-氯-2,2':6',2''-三联吡啶 在 iron(II) chloride 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 22.0h， 以78%的产率得到4'-(N-2-hydroxyethyl-N-methylamino)-2,2':6',2''-terpyridine
  参考文献：
  名称：

  （2,2'：6'，2''-terpyridine）platinum（II）配合物对利什曼原虫，诺氏锥虫和布鲁氏锥虫的细胞毒性。

  摘要：

  一系列（2,2'：6'，2''-叔吡啶）铂（II）配合物在体外具有对抗原生动物利什曼原虫，克鲁氏锥虫和布鲁氏锥虫等热带动物利什曼原虫病的致病生物的抗原生动物活性。锥虫病。最佳化合物分别以1 microM的浓度引起100％和78％的胞内鞭毛虫形式的曲霉菌的生长抑制，而在100毫克的浓度下，对布鲁氏梭菌的血型拟鞭毛虫形式的血液的生长抑制作用分别为100％和78％。浓度为0.03 microM。比较了其中配合物（其中铂（II）的第四个配体能够被取代的惰性羟乙基硫醇盐配合物取代）的结果。氨基配合物显示出很高的抗原生动物活性，表明2,2'的反式影响：

  DOI：

  10.1021/jm981074c

文献信息

• Use of metal complex compounds as catalysts for oxidation using molecular oxygen or air
  申请人：Wieprecht Torsten

  公开号：US20060019853A1

  公开（公告）日：2006-01-26

  Use, as a catalyst for oxidation reactions using molecular oxygen and/or air, of at least one metal complex compound of formula (1) wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge of Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen; unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —SR 13 , —SO 2 R 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —NR 14 R 15 ; —(C 1 -C 6 alkylene)-NR 14 R 15 ; —N (+) R 14 R 15 R 16 ; —(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16 ; —N(R 13 )—(C 1 -C 6 alkylene)-NR 14 R 15 ; —N[(C 1 -C 6 alkylene)-NR 14 R 15 ] 2 ; —N(R 13 )—(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16 ; —N[(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16]2 ; —N(R 13 )—N—R 14 R 15 or —N(R 13 )N″R 14 R 15 R 16 , wherein R 13 is as defined above and R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 , together with the nitrogen atom linking them, form an unsubstituted or substituted 5-, 6- or 7-membered ring which may contain further hetero atoms. [L n Me m X p ] z Y q (1)

  使用至少一种具有以下式（1）的金属配合物化合物作为氧化反应的催化剂，其中Me为锰、钛、铁、钴、镍或铜，X为配位或桥联基团，n和m分别独立地为1至8之间的整数，p为0至32之间的整数，z为金属配合物的电荷，Y为对离子，q=z/(Y的电荷)，L为具有以下式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地为氢；未取代或取代的C1-C18烷基或芳基；氰基；卤素；硝基；—COOR12或—SO3R12，其中R12在每种情况下为氢、阳离子或未取代或取代的C1-C18烷基或芳基；—SR13、—SO2R13或—OR13，其中R13在每种情况下为氢或未取代或取代的C1-C18烷基或芳基；—NR14R15；—(C1-C6烷基)-NR14R15；—N(+)R14R15R16；—(C1-C6烷基)-N(+)R14R15R16；—N(R13)—(C1-C6烷基)-NR14R15；—N[(C1-C6烷基)-NR14R15]2；—N(R13)—(C1-C6烷基)-N(+)R14R15R16；—N[(C1-C6烷基)-N(+)R14R15R16]2；—N(R13)—N—R14R15或—N(R13)N″R14R15R16，其中R13如上定义，R14、R15和R16各自独立地为氢或未取代或取代的C1-C18烷基或芳基，或R14和R15与连接它们的氮原子一起形成未取代或取代的5、6或7成员环，该环可能含有进一步的杂原子。[LnMemXp]zYq（1）
• TERPYRIDINE-PLATINUM(II) COMPLEXES
  申请人：——

  公开号：US20020013306A1

  公开（公告）日：2002-01-31

  A new class of 2,2′:6′,2″-terpyridine-platinum (II) and substituted 2,2′:6′,2″-terpyridine-platinum (II) complexes in which an N— or O— or halo nucleophile is the fourth ligand to platinum. The compounds are potent intercalators of DNA. Some have antitumour activity. Some have anti-parasitic activity. A new method of preparing the complexes involves reacting a Pt complex of 1,5-cyclooctadiene with a 2,2′:6′,2″-terpyridine.

  一类新型的2,2′:6′,2″-三吡啶铂(II)和取代的2,2′:6′,2″-三吡啶铂(II)配合物，其中N—或O—或卤素亲核试剂是铂的第四个配体。这些化合物是DNA的有效插入剂，其中一些具有抗肿瘤活性，一些具有抗寄生虫活性。一种新的制备这些配合物的方法是将1,5-环辛二烯的Pt配合物与2,2′:6′,2″-三吡啶反应。
• Use of metal complex compounds as oxidation catalysts
  申请人：——

  公开号：US20040142843A1

  公开（公告）日：2004-07-22

  Use of metal complex compounds of formula (1): [L n Me m X p ] z Y q wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, y is a counter-ion, q=z/(charge Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen; unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —SR 13 , —OR 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —N(R 13 )—NR′ 13 R″ 13 wherein R 13 , R′ 13 and R″ 13 are as defined above for R 13 ; —NR 14 R 15 or —N + R 14 R 15 R 16 wherein R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 together with the nitrogen atom bonding them form an unsubstituted or substituted 5 -, 6 - or 7 -membered ring which may optionally contain further hetero atoms; with the proviso that R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 11 are not simultaneously hydrogen, as catalysts for oxidation reactions, and the novel metal complex compounds of formula (1) and the novel ligands of formula (2). 1

  使用公式（1）的金属配合物化合物：[LnMemXp]zYq，其中Me是锰、钛、铁、钴、镍或铜，X是配位或桥联基团，n和m分别独立地为1至8的整数，p为0至32的整数，z是金属配合物的电荷，y是反离子，q=z/（反离子Y的电荷），L是公式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地为氢；未取代或取代的C1-C18烷基或芳基；氰基；卤素；硝基；—COOR12或—SO3R12，其中R12在每种情况下为氢、阳离子或未取代或取代的C1-C18烷基或芳基；—SR13、—OR13或—OR13，其中R13在每种情况下为氢或未取代或取代的C1-C18烷基或芳基；—N（R13）—NR'13R"13，其中R13、R'13和R"13如上所定义为R13；—NR14R15或—N+R14R15R16，其中R14、R15和R16各自独立地为氢或未取代或取代的C1-C18烷基或芳基，或者R14和R15与其结合的氮原子形成未取代或取代的5-、6-或7-成员环，该环可以选择性地包含进一步的杂原子；但是，R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11不能同时为氢，作为氧化反应的催化剂，以及公式（1）的新金属配合物化合物和公式（2）的新配体。
• Coloring keratin fibers with metal complexes
  申请人：End Nicole

  公开号：US20090106915A1

  公开（公告）日：2009-04-30

  The present invention concerns coloring keratin fibers, especially human hair, with colored metal complexes.

  本发明涉及使用有色金属络合物对角蛋白纤维进行着色，特别是人类头发。
• Use of metal complex compounds comprising pyridine pyrimidine or s-triazine derived ligands as catalysts for oxidations with organic peroxy acids and/or precursors of organic peroxy acids and h202
  申请人：Wieprecht Torsten

  公开号：US20090189119A1

  公开（公告）日：2009-07-30

  The invention accordingly relates to the use as catalysts of at least one metal complex of formula (1) [L n Me m X p ] z Y q (1), wherein all substituents have the meanings as defined in the claims for oxidation reactions with organic peroxy acids and/or precursors of organic peroxy acid and H 2 O 2 , as well as to novel detergent compositions.

  该发明涉及使用至少一个化合物的金属配合物作为催化剂，该化合物的化学式为（1）[LnMemXp]zYq(1)，其中所有取代基的含义如权利要求所定义，用于有机过氧酸和/或有机过氧酸前体以及H2O2的氧化反应，以及新型洗涤剂组合物。