1-丙炔-三-正-丁基锡 | 64099-82-7

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机锡
• 分子结构分类: 有机化合物 - 乙炔化物 - 金属乙炔化物
• 中文名称: 1-丙炔-三-正-丁基锡
• 中文别名: 三丁基丙炔锡烷；1-丙炔三正丁基锡
• 英文名称: 1-propynyltributylstannane
• 英文别名: tributyl(prop-1-yn-1-yl)stannane；tributyl(1-propynyl)tin；tributyl(prop-1-ynyl)stannane；tributylpropynylstannane；tributyl(1-propynyl)stannane；tri-n-butyl(1-propynyl)stannane；tri-n-butyl propynyl stannane；1-propynyltri-n-butyltin；tributyl-n-propynyltin；tributylpropynyltin；(1-propynyl)-tri-n-butylstannane
• CAS: 64099-82-7
• 化学式: C₁₅H₃₀Sn
• 分子量: 329.113
• InChiKey: KCQJLTOSSVXOCC-UHFFFAOYSA-N

物化性质

• 沸点：
  277 °C (lit.)
• 密度：
  1.082 g/mL at 25 °C (lit.)
• 闪点：
  >230 °F
• 稳定性/保质期：
  远离氧化物。

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• TSCA：
  No
• 危险等级：
  6.1
• 危险品标志：
  T,N
• 安全说明：
  S35,S36/37/39,S45,S60,S61
• 危险类别码：
  R48/23/25,R36/38,R21,R50/53,R25
• WGK Germany：
  3
• 海关编码：
  2931900090
• 包装等级：
  II
• 危险类别：
  6.1
• 危险品运输编号：
  UN 2788 6.1/PG 3
• 储存条件：
  存放在密封容器中，并置于阴凉、干燥处。储存地点需上锁，钥匙应由技术人员及其助手保管。同时，储存位置要远离氧化剂及冷藏环境。

SDS

Name:	Tributylpropynylstannane Material Safety Data Sheet
Synonym:	Propynyltributylstannane; Propynyltributyltin
CAS:	64099-82-7

Section 1 - Chemical Product MSDS Name:Tributylpropynylstannane Material Safety Data Sheet
Synonym:Propynyltributylstannane; Propynyltributyltin

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
64099-82-7	Tributylpropynyltin	80	unlisted

Hazard Symbols: T N
Risk Phrases: 21 25 36/38 48/23/25 50/53

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful in contact with skin. Toxic if swallowed. Irritating to eyes and skin. Toxic : danger of serious damage to health by prolonged exposure through inhalation and if swallowed. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
The critical effect of tributyltin compounds in rats is on the immune system (ACGIH 7th Edition Documentation of the TLVs). Exposure limits have been recommended for organotin compounds to minimize the potential for adverse effects on immune function and the CNS.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid breathing vapor or mist.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 64099-82-7: United Kingdom, WEL - TWA: (listed as tin organic compounds): 0.1 mg/m3 TWA (except cyhexatin, as Sn) United Kingdom, WEL - STEL: (listed as tin organic compounds): 0.
mg/m3 STEL (except cyhexatin, as Sn) United States OSHA: 0.1 mg/m3 TWA (as Sn) (listed under Tin orga compounds).
Belgium - TWA: (listed as tin organic compounds): 0.1 mg/m3 VLE ( Sn) Belgium - STEL: (listed as tin organic compounds): 0.2 mg/m3 VLE Sn) France - VME: (listed as tin organic compounds): 0.1 mg/m3 VME (a Sn) France - VLE: (listed as tin organic compounds): 0.2 mg/m3 VLE (a Sn) Germany: (listed as tin organic compounds): 0.1 mg/m3 VME (as Sn) Germany: (listed as tin organic compounds): Skin absorber Malaysia: (listed as tin organic compounds): 0.1 mg/m3 TWA (as Sn Netherlands: (listed as tin organic compounds): 0.2 mg/m3 STEL (a Sn) Netherlands: (listed as tin organic compounds): 0.1 mg/m3 MAC (as Spain: (listed as tin organic compounds): 0.1 mg/m3 VLA-ED (as Sn Spain: (listed as tin organic compounds): 0.2 mg/m3 VLA-EC (as Sn Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 270 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: > 109 deg C (> 228.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.082
Molecular Formula: C15H30Sn
Molecular Weight: 329.11

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, tin/tin oxides.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 64099-82-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Tributylpropynyltin - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION
Other No information available.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: ORGANOTIN COMPOUND, LIQUID, N.O.S.
Hazard Class: 6.1
UN Number: 2788
Packing Group: III
IMO
Shipping Name: ORGANOTIN COMPOUND, LIQUID, N.O.S.
Hazard Class: 6.1
UN Number: 2788
Packing Group: III
RID/ADR
Shipping Name: ORGANOTIN COMPOUND, LIQUID, N.O.S.
Hazard Class: 6.1
UN Number: 2788
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 21 Harmful in contact with skin.
R 25 Toxic if swallowed.
R 36/38 Irritating to eyes and skin.
R 48/23/25 Toxic : danger of serious damage to
health by prolonged exposure through inhalation and if
swallowed.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 35 This material and its container must be
disposed of in a safe way.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 64099-82-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 64099-82-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 64099-82-7 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-丙炔-三-正-丁基锡 生成 2,2-dimethylpropanoyloxymethyl (6R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-5-yl)-2-hydroxyiminoacetyl]amino]-8-oxo-3-prop-1-ynyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  BAKER, STEPHEN R.;FARINA, VITTORIO;SAPINO, CHESTER (JR)

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(三甲基硅基)丙炔 、 三丁基氧化锡 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 1-丙炔-三-正-丁基锡
  参考文献：
  名称：

  TW2016/4185

  摘要：

  公开号：
• 作为试剂：
  描述：

  2-acetoxy-4-phenyl-3-butenenitrile 在 1-丙炔-三-正-丁基锡 作用下， 反应 24.0h， 以67%的产率得到(E)-4-苯基-3-丁烯腈
  参考文献：
  名称：

  Organotin nucleophiles. 5. Palladium-catalyzed allylic propargylation with allenylstannane

  摘要：

  DOI：

  10.1021/jo00174a027

文献信息

• [EN] NAPTHALENE ACETIC ACID DERIVATIVES AGAINST HIV INFECTION<br/>[FR] DÉRIVÉS D'ACIDE NAPHTALÈNE ACÉTIQUE CONTRE L'INFECTION PAR LE VIH
  申请人：GILEAD SCIENCES INC

  公开号：WO2013103738A1

  公开（公告）日：2013-07-11

  The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

  该发明提供了作为d的化合物及其盐。该发明还提供了包括本文所披露的化合物的药物组合物，用于制备本文所披露的化合物的过程，用于制备本文所披露的化合物的中间体，以及使用本文所披露的化合物治疗HIV感染、治疗HIV病毒的增殖、治疗艾滋病或延缓哺乳动物发生艾滋病或ARC症状的治疗方法。
• [EN] SOMATOSTATIN MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE LA SOMATOSTATINE ET UTILISATIONS DE CES DERNIERS
  申请人：CRINETICS PHARMACEUTICALS INC

  公开号：WO2019023278A1

  公开（公告）日：2019-01-31

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

  本文描述了一些肽类调节剂化合物，制备这类化合物的方法，包含这类化合物的药物组合物和药物，以及利用这类化合物治疗需要调节生长抑素活性的疾病、症状或疾病的方法。
• [EN] PROTEASOME ACTIVITY ENHANCING COMPOUNDS<br/>[FR] COMPOSÉS RENFORÇANT L'ACTIVITÉ DES PROTÉASOMES
  申请人：PROTEOSTASIS THERAPEUTICS INC

  公开号：WO2015073528A1

  公开（公告）日：2015-05-21

  The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, the methods of synthesis of the compouds of interest, and to methods for the treatment of a condition associated with a dysfunction in proteostasis, such as cancer, inflammatory conditions, neurodegeneration, metabolic conditions, comprising administering an effective amount of a compound of the invention.

  本发明涉及具有化学式（I）、（II）、（III）、（IV）和（V）的化合物，其组成物，所述化合物的合成方法，以及用于治疗与蛋白质稳态功能障碍相关的疾病的方法，例如癌症、炎症性疾病、神经退行性疾病、代谢性疾病，包括给予本发明化合物的有效量。
• New CRTh2 antagonists
  申请人：Almirall, S.A.

  公开号：EP2548876A1

  公开（公告）日：2013-01-23

  The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

  本发明涉及式(I)的化合物，制备这种化合物的方法以及它们在治疗病理状况或疾病中的应用，该病理状况或疾病容易通过CRTh2拮抗活性得到改善。
• [EN] TRIAZOLE AGONISTS OF THE APJ RECEPTOR<br/>[FR] TRIAZOLES AGONISTES DU RÉCEPTEUR APJ
  申请人：AMGEN INC

  公开号：WO2016187308A1

  公开（公告）日：2016-11-24

  Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.

  公式I和公式II的化合物，其药用盐，上述任何一种的立体异构体，或它们的混合物是APJ受体的激动剂，并可用于治疗心血管和其他疾病。公式I和公式II的化合物具有以下结构，其中变量的定义在此提供。