propane-1,1-dihydroperoxide | 1070799-48-2

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氢过氧化物
• 英文名称: propane-1,1-dihydroperoxide
• 英文别名: 1,1-dihydroperoxypropane
• CAS: 1070799-48-2
• 化学式: C₃H₈O₄
• 分子量: 108.094
• InChiKey: LPZSIYDMHWOREJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  propane-1,1-dihydroperoxide 、 1,1-二乙氧基环戊烷 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以43%的产率得到8-ethyl-6,7,9,10-tetraoxaspiro[4.5]decane
  参考文献：
  名称：

  Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides

  摘要：

  A convenient synthesis of new unsymmetrically substituted 1,2,4,5-tetroxanes and novel unsymmetrical alkoxy-substituted 1,2,4,5-tetroxanes starting from primary dihydroperoxides was developed. The structure of some tetroxanes was unambiguously assigned by X-ray crystal analysis giving interesting insights in the configuration and conformation of disubstituted 1,2,4,5-tetroxanes. Some of these tetroxanes showed notable antimalarial activity in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.151
• 作为产物：
  描述：

  6-ethyl-7-oxabicyclo[4.1.0]heptan-2-one 在 (1S)-(+)-10-camphorsulfonic acid 、 双氧水 作用下， 以 乙醚 为溶剂， 以19%的产率得到propane-1,1-dihydroperoxide
  参考文献：
  名称：

  环氧酮与过氧化氢-乙烷-1,1-二氢过氧化物的反应非常稳定。

  摘要：

  DOI：

  10.1002/chem.200800932

文献信息

• A simple, efficient and versatile synthesis of primary gem-dihydroperoxides from aldehydes and hydrogen peroxide
  作者：Alexander Bunge、Hans-Jürgen Hamann、Jürgen Liebscher

  DOI：10.1016/j.tetlet.2008.11.055

  日期：2009.2

  Aldehydes were efficiently converted directly into the corresponding gem-dihydroperoxides (DHPs) on treatment with aqueous 70% H2O2 in a biphasic system with ether catalyzed by camphorsulfonic acid. The synthesis represents the most versatile access to this class of compounds.

  醛被有效直接转化为相应的宝石上治疗用含水70％H -dihydroperoxides吡啶类（DHP）2 Ô 2中的两相体系与由樟脑磺酸催化的醚。合成代表了此类化合物最通用的获取途径。
• Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides
  作者：Hans-Jürgen Hamann、Mandy Hecht、Alexander Bunge、Malgorzata Gogol、Jürgen Liebscher

  DOI：10.1016/j.tetlet.2010.10.151

  日期：2011.1

  A convenient synthesis of new unsymmetrically substituted 1,2,4,5-tetroxanes and novel unsymmetrical alkoxy-substituted 1,2,4,5-tetroxanes starting from primary dihydroperoxides was developed. The structure of some tetroxanes was unambiguously assigned by X-ray crystal analysis giving interesting insights in the configuration and conformation of disubstituted 1,2,4,5-tetroxanes. Some of these tetroxanes showed notable antimalarial activity in vitro. (C) 2010 Elsevier Ltd. All rights reserved.
• Reaction of Epoxyketones with Hydrogen Peroxide-Ethane-1,1-dihydroperoxide as a Surprisingly Stable Product
  作者：Hans-Jürgen Hamann、Alexander Bunge、Jürgen Liebscher

  DOI：10.1002/chem.200800932

  日期：2008.8.8