3-Hydroxy-5-methylsulfanyl-pentanoic acid | 903527-90-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxy-5-methylsulfanyl-pentanoic acid
• 英文别名: DL--Homomethionine；3-hydroxy-5-methylsulfanylpentanoic acid
• CAS: 903527-90-2
• 化学式: C₆H₁₂O₃S
• 分子量: 164.225
• InChiKey: GSKBRSYYWPTGJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  对甲苯磺酸甲酯 、 3-Hydroxy-5-methylsulfanyl-pentanoic acid 在 甲酸 作用下， 反应 3.0h， 以68%的产率得到gonyol
  参考文献：
  名称：

  Gonyol: Methionine-induced sulfonium accumulation in a dinoflagellate Gonyaulax polyedra

  摘要：

  Gonyol, 3S-5-dimethylsulfonio-3-hydroxylpentanoate was isolated from a dinoflagellate Gonyaulax polyedra cultured in a medium containing methionine and the structure was elucidated by spectroscopic method and confirmed by chemical synthesis. Gonyol was shown to be biogenetically derived from methionine and acetic acid.

  DOI：

  10.1016/s0040-4039(00)61364-3
• 作为产物：
  描述：

  3-Hydroxy-5-methylsulfanyl-pentanoic acid methyl ester 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以38%的产率得到3-Hydroxy-5-methylsulfanyl-pentanoic acid
  参考文献：
  名称：

  Gonyol: Methionine-induced sulfonium accumulation in a dinoflagellate Gonyaulax polyedra

  摘要：

  Gonyol, 3S-5-dimethylsulfonio-3-hydroxylpentanoate was isolated from a dinoflagellate Gonyaulax polyedra cultured in a medium containing methionine and the structure was elucidated by spectroscopic method and confirmed by chemical synthesis. Gonyol was shown to be biogenetically derived from methionine and acetic acid.

  DOI：

  10.1016/s0040-4039(00)61364-3

文献信息

• [EN] COMPOUNDS, REAGENTS, AND USES THEREOF<br/>[FR] COMPOSÉS, RÉACTIFS ET UTILISATIONS ASSOCIÉES
  申请人：METABOLON INC

  公开号：WO2019067699A1

  公开（公告）日：2019-04-04

  The present invention provides a compound of formula (I), formula (II), formula (III), (IV) or a salt thereof, compositions and methods of making the compound, methods and reagents for measuring the compound, and kits using the same. The use of a compound of formula (I), formula (II), formula (III), or formula (IV) for assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, and diagnosing or monitoring chronic kidney disease is also described.

  本发明提供了式(I)、式(II)、式(III)、(IV)或其盐的化合物，以及制备该化合物的组合物和方法，测定该化合物的方法和试剂，以及使用该化合物的工具包。还描述了使用式(I)、式(II)、式(III)或式(IV)的化合物来评估或监测受试者的肾功能，确定发展肾功能减退的易感性，根据肾功能水平对受试者进行分类，以及诊断或监测慢性肾脏疾病。
• Acetyl-CoA acyltransferase gene disrupted bacterium for producing polyhydroxyalkanoate and method for producing polyhydroxyalkanoate using the same
  申请人：Nomoto Tsuyoshi

  公开号：US20060172399A1

  公开（公告）日：2006-08-03

  A method for producing a polyhydroxyalkanoate with improved productivity and composition is provided. Polyhydroxyalkanoate is produced by a bacterium for producing polyhydroxyalkanoate in which a gene encoding acetyl-CoA acyltransferase is disrupted.

  本发明提供了一种生产聚羟基烷酸的方法，其生产率和成分均有所提高。聚羟基烷酸是由一种生产聚羟基烷酸的细菌生产的，在这种细菌中，编码乙酰-CoA酰基转移酶的基因被破坏。
• JP2002114758A
  申请人：——

  公开号：JP2002114758A

  公开（公告）日：2002-04-16
• US7527963B2
  申请人：——

  公开号：US7527963B2

  公开（公告）日：2009-05-05
• Gonyol: Methionine-induced sulfonium accumulation in a dinoflagellate Gonyaulax polyedra
  作者：Hideshi Nakamura、Kazuhiro Fujimaki、Osamu Sampei、Akio Murai

  DOI：10.1016/s0040-4039(00)61364-3

  日期：——

  Gonyol, 3S-5-dimethylsulfonio-3-hydroxylpentanoate was isolated from a dinoflagellate Gonyaulax polyedra cultured in a medium containing methionine and the structure was elucidated by spectroscopic method and confirmed by chemical synthesis. Gonyol was shown to be biogenetically derived from methionine and acetic acid.