4-maleimidobutyric acid N-succinimidyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-maleimidobutyric acid N-succinimidyl ester
• 英文别名: (2,5-Dioxopyrrol-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate
• 化学式: C₁₂H₁₀N₂O₆
• 分子量: 278.221
• InChiKey: IHKFWJFRIPGFST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-maleimidobutyric acid N-succinimidyl ester 在 sodium dihydrogenphosphate 、 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  TW2020/41237

  摘要：

  公开号：
• 作为产物：
  描述：

  4-马来酰亚胺丁酸 、 N-羟基马来酰亚胺 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以63%的产率得到4-maleimidobutyric acid N-succinimidyl ester
  参考文献：
  名称：

  TW2020/41237

  摘要：

  公开号：

文献信息

• ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF
  申请人：Cheng Heng

  公开号：US20110027274A1

  公开（公告）日：2011-02-03

  Antiproliferative compounds having a structure represented by formula (II), where n, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:

  具有以下式子（II）所代表结构的抗增殖化合物，其中n，R1，R2，R3，R4和R5的定义如本文所述，可用于治疗肿瘤，可选择将其与配体（例如抗体）结合使用：
• Physical modification of carbon nanotubes with a dendrimer bearing terminal mercaptoundecahydrododecaborates (Na ₂ B ₁₂ H ₁₁ S)
  作者：Masahiro Yamagami、Tomoyuki Tajima、Kango Ishimoto、Hideaki Miyake、Hiroyuki Michiue、Yutaka Takaguchi

  DOI：10.1002/hc.21467

  日期：——

  AbstractThe thiol‐substituted B12‐cluster mercaptoundecahydro‐closo‐dodecaborate Na2[B12H11SH] (BSH) was successfully attached to a poly(amido)amine (PAMAM) dendrimer, which contains a bis(decyloxy)decane core. The physical modification of single‐walled carbon nanotubes (SWCNTs) with dendrimer(SB12)4 afforded a SWCNT/dendrimer(SB12)4 nanohybrid that exhibited NIR‐I‐to‐NIR‐II fluorescence. Herein, we describe a promising strategy for in vivo imaging of boron clusters that may be widely applicable to boron neutron capture therapy.
• TARGET RECOGNITION MOLECULE AND A METHOD FOR IMMOBILIZING THE SAME
  申请人：SHIMIZU Yuichiro

  公开号：US20110017599A1

  公开（公告）日：2011-01-27

  A novel target recognition molecule is provided which has a electrostatic property whereby such target recognition molecules can be densely brought together in a self-assembly manner in a predetermined region of an analytical chip and, in addition, can be reversibly or irreversibly stably immobilized there. This target recognition molecule has a target recognition peptide segment as a specific binding site for a target substance, an electrostatically-charged segment which is provided with three or more electrostatically-charged functional groups capable of being electrically charged with charges of the same polarity in the same solution and which has no functional groups that become electrically charged to different polarities in the same solution, and a connecting segment which chemically links with the target recognition peptide segment and with the electrostatically-charged segment for establishing a connection between both the segments.
• TUBULYSIN DERIVATIVES
  申请人：MedImmune LLC

  公开号：US20160339114A1

  公开（公告）日：2016-11-24

  Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone, as drug conjugates or in combination with other chemotherapies are provided.
• US8394922B2
  申请人：——

  公开号：US8394922B2

  公开（公告）日：2013-03-12