Methyl Salicylate MEM Ether | 81254-82-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl Salicylate MEM Ether
• 英文别名: methyl 2-[(2-methoxyethoxy)methoxy]benzoate；Methyl 2-(2-methoxyethoxymethoxy)benzoate
• CAS: 81254-82-2
• 化学式: C₁₂H₁₆O₅
• 分子量: 240.256
• InChiKey: KLNZQPVOEABLMT-UHFFFAOYSA-N

物化性质

• 沸点：
  337.1±27.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl Salicylate MEM Ether 在 Montmorillonite K 10 作用下， 以 苯 为溶剂， 反应 1.5h， 以96%的产率得到水杨酸甲酯
  参考文献：
  名称：

  Chelation-Controlled Selectivity in the Clay-Catalyzed Deprotection of Phenolic Methoxy Methyl Ethers

  摘要：

  DOI：

  10.1021/jo015578l
• 作为产物：
  描述：

  2-甲氧基乙氧基甲基氯 、 水杨酸甲酯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以99%的产率得到Methyl Salicylate MEM Ether
  参考文献：
  名称：

  Inhibitors of the FEZ-1 metallo-β-lactamase

  摘要：

  Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K-i of 6.1 +/- 0.71 mu M against the FEZ-1 MBL but does not significantly inhibit the IMP-1, Bell, CphA or L1 MBLs. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.11.053

文献信息

• Preparation of 3-acyl-3-cyclobutene-1,2-diones and some related monoacetals
  作者：Lanny S. Liebeskind、Marvin S. Yu、Richard W. Fengl

  DOI：10.1021/jo00065a016

  日期：1993.6

  3-(Tri-n-butylstannyl)-3-cyclobutene-1,2-diones and 4-methyl-3-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione 2-ethylene acetal participate in palladium/copper-cocatalyzed cross-coupling with acyl halides and in palladium-catalyzed carbonylative cross-coupling with aryl/heteroaryl iodides. The derived 3-acyl-3-cyclobutenediones and cyclobutenedione monoacetals should extend the potential of cyclobutenedione-based synthetic organic methodology.
• Lunney; Hagen; Domagala, Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2664 - 2677
  作者：Lunney、Hagen、Domagala、Humblet、Kosinski、Tait、Warmus、Wilson、Ferguson、Hupe、Tummino、Baldwin、Bhat、Liu、Erickson

  DOI：——

  日期：——
• Chelation-Controlled Selectivity in the Clay-Catalyzed Deprotection of Phenolic Methoxy Methyl Ethers
  作者：Jay P. Deville、Victor Behar

  DOI：10.1021/jo015578l

  日期：2001.6.1
• Inhibitors of the FEZ-1 metallo-β-lactamase
  作者：Benoît M.R. Liénard、Louise E. Horsfall、Moreno Galleni、Jean-Marie Frère、Christopher J. Schofield

  DOI：10.1016/j.bmcl.2006.11.053

  日期：2007.2

  Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K-i of 6.1 +/- 0.71 mu M against the FEZ-1 MBL but does not significantly inhibit the IMP-1, Bell, CphA or L1 MBLs. (c) 2006 Elsevier Ltd. All rights reserved.