1,2,3,4-四氟-5,8-二羟基蒽并醌 | 102822-05-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1,2,3,4-四氟-5,8-二羟基蒽并醌
• 中文别名: 1,2,3,4-四氟-5,8-二羟基蒽醌
• 英文名称: 1,2,3,4-tetrafluoro-5,6-dihydroxyanthra-9,10-quinone
• 英文别名: 1,2,3,4-tetrafluoro-5,8-dihydroxyanthraquinone；5,6,7,8-tetrafluoroquinizarin；1,2,3,4-tetrafluoro-5,8-dihydroxyanthracene-9,10-dione
• CAS: 102822-05-9
• 化学式: C₁₄H₄F₄O₄
• 分子量: 312.177
• InChiKey: PKJLMPNJHMHOIE-UHFFFAOYSA-N

物化性质

• 熔点：
  242-245 °C(lit.)
• 沸点：
  536.1±50.0 °C(Predicted)
• 密度：
  1.806±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，没有已知危险反应。应避免与强氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2914700090
• 储存条件：
  请将贮藏器密封，并将其存放在阴凉、干燥处。确保工作环境中具有良好通风或排气设施。

反应信息

• 作为反应物：
  描述：

  1,2,3,4-四氟-5,8-二羟基蒽并醌 在 盐酸 、 tin 、 溶剂黄146 作用下， 以95%的产率得到5,6,7,8-tetrafluoro-9,10-dihydroxy-2,3-anthracene-1,4-dione
  参考文献：
  名称：

  Perfluoropentacene:  High-Performance p−n Junctions and Complementary Circuits with Pentacene

  摘要：

  We report the synthesis and characterization of perfluoropentacene as an n-type semiconductor for organic field-effect transistors (OFETs). Perfluoropentacene is a planar and crystalline material that adopts a herringbone structure as observed for pentacene. OFETs with perfluoropentacene were constructed using top-contact geometry, and an electron mobility of 0.11 cm2 V-1 s-1 was observed. Bipolar OFETs with perfluoropentacene and pentacene function at both negative and positive gate voltages. The improved p-n junctions are probably due to the similar d-spacings of both acenes. Complementary inverter circuits were fabricated, and the transfer characteristics exhibit a sharp inversion of the output signal with a high-voltage gain.

  DOI：

  10.1021/ja0476258
• 作为产物：
  描述：

  3,4,5,6-四氟邻苯二甲酸 在 三氯化铝 、 乙酰氯 、 sodium chloride 作用下， 反应 1.0h， 生成 1,2,3,4-四氟-5,8-二羟基蒽并醌
  参考文献：
  名称：

  Perfluoropentacene:  High-Performance p−n Junctions and Complementary Circuits with Pentacene

  摘要：

  We report the synthesis and characterization of perfluoropentacene as an n-type semiconductor for organic field-effect transistors (OFETs). Perfluoropentacene is a planar and crystalline material that adopts a herringbone structure as observed for pentacene. OFETs with perfluoropentacene were constructed using top-contact geometry, and an electron mobility of 0.11 cm2 V-1 s-1 was observed. Bipolar OFETs with perfluoropentacene and pentacene function at both negative and positive gate voltages. The improved p-n junctions are probably due to the similar d-spacings of both acenes. Complementary inverter circuits were fabricated, and the transfer characteristics exhibit a sharp inversion of the output signal with a high-voltage gain.

  DOI：

  10.1021/ja0476258

文献信息

• Autophagy and phospholipidosis pathway assays
  申请人：Patton Wayne Forrest

  公开号：US09250249B2

  公开（公告）日：2016-02-02

  Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.

  提供的是用于检测和监测自噬和磷脂沉积症的检测方法，包括溶酶体贮积病的进展。可以监测用于溶酶体贮积病的药物和治疗方法在溶酶体贮积病条件下的有效性。还可以筛选药物候选物和疑似毒性剂对细胞、组织和器官的毒性。还提供了区分磷脂沉积症激活剂和自噬途径干扰剂的方法。
• Quinizarin compound, method for production thereof, and use therefor
  申请人：Nippon Shokubai Co., Ltd.

  公开号：US05608091A1

  公开（公告）日：1997-03-04

  This invention is to provide a novel quinizarin compound which has a quinizarin structure represented by a following formula (1) having one to four of the 5, 6, 7, and 8 positions and at least either the 6 or 7 position formed of at least one member selected from the class consisting of secondary amino groups, alkylthio groups, and optionally substituted phenylthio groups, and having the remaining positions thereof formed of at least one member selected from the class consisting of hydrogen atom, halogen atoms, amino group, hydroxy group, alkoxy groups, and optionally substituted phenoxy groups, a method for the production thereof, and a dye, an electrophotographic grade color toner composition, a thermal-transfer recording sheet, an optical recording medium, an ink jet grade ink composition and a color filter severally comprising the quinizarin compound. ##STR1##

  该发明旨在提供一种新型的喹诺酮化合物，其具有以下公式（1）所代表的喹诺酮结构，其在5、6、7和8位置中有一到四个位置，且至少在6或7位置中至少有一个成员选自包括二级氨基团、烷基硫基团和可选择取代的苯硫基团的类别，并且其余位置至少有一个成员选自包括氢原子、卤素原子、氨基、羟基、烷氧基团和可选择取代的苯氧基团的类别，以及包括该喹诺酮化合物的生产方法、染料、电子摄影级彩色调色剂组合物、热传递记录纸、光学记录介质、喷墨级墨水组合物和彩色滤光片。
• 5,6,7,8-tetrafluoroanthraquinone derivatives
  申请人：Nippon Shokubai Kagaku Kogyo Co., Ltd.

  公开号：US04647411A1

  公开（公告）日：1987-03-03

  A 5,6,7,8-tetrafluoroanthraquinone derivative represented by the general formula I: ##STR1## wherein R.sup.1 and R.sup.2 independently stand for --OH or ##STR2## (where R.sup.3 and R.sup.4 independently stand for hydrogen an alkyl of 1 to 4 carbon atoms or a phenyl) and X and Y independently hydrogen atom or a halogen atom.

  一种以一般公式I表示的5,6,7,8-四氟蒽醌衍生物：##STR1##其中R1和R2分别代表--OH或##STR2##（其中R3和R4分别代表1至4个碳原子的氢、烷基或苯基），X和Y分别为氢原子或卤素原子。
• Fluorochromes for organelle tracing and multi-color imaging
  申请人：Patton Wayne Forrest

  公开号：US20100062429A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和试剂盒，用于鉴定感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，用于确定细胞器的位置、数量，甚至用于区分感兴趣的细胞中的细胞器。
• Novel fluorochromes for organelle tracing and multi-color imaging
  申请人：Pande Praveen

  公开号：US20100062460A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和工具包，用于识别感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，以识别感兴趣细胞中细胞器的位置、位置或数量，甚至用于区分细胞器。