(S)-2-(2-Allyloxycarbonylamino-acetylamino)-3-hydroxy-propionic acid methyl ester | 145521-14-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(2-Allyloxycarbonylamino-acetylamino)-3-hydroxy-propionic acid methyl ester
• CAS: 145521-14-8
• 化学式: C₁₀H₁₆N₂O₆
• 分子量: 260.247
• InChiKey: QFTQRZMUSXYGNR-ZETCQYMHSA-N

物化性质

• 沸点：
  509.1±50.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.45
• 重原子数：
  18.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  113.96
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-2-(2-Allyloxycarbonylamino-acetylamino)-3-hydroxy-propionic acid methyl ester 以 水 为溶剂， 反应 42.0h， 生成 (2S)-2-[[2-(prop-2-enoxycarbonylamino)acetyl]amino]-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropanoic acid
  参考文献：
  名称：

  Enzymatic synthesis of β-galactosyldipeptides and of β-1,3-digalactosylserine derivatives using β-galactosidase

  摘要：

  The transgalactosidation from lactose to dipeptides has been achieved using beta-galactosidase from E. Coli as catalyst. Two series of dipeptides have been studied, each of them containing a serine residue. The best condensations occur when serine is at the N-terminal end of the dipeptide. Mild hydrolysis of the ester group of the labile glycosyl-dipeptide derivatives has been achieved using subtilisin. We also describe the condensation of lactose with beta-galactosyl serine to give beta-1,3-digalactosyl-serine derivatives.

  DOI：

  10.1016/s0040-4020(01)85615-5