1-(4'-methoxy-phenyl)-3-acetoxy-4,4-bis(methylthio)azetidin-2-one | 228720-63-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-(4'-methoxy-phenyl)-3-acetoxy-4,4-bis(methylthio)azetidin-2-one
• 英文别名: 1-(4'-methoxyphenyl)-3-acetoxy-4,4-bis(methylthio)azetidin-2-one；[1-(4-Methoxyphenyl)-2,2-bis(methylsulfanyl)-4-oxoazetidin-3-yl] acetate
• CAS: 228720-63-6
• 化学式: C₁₄H₁₇NO₄S₂
• 分子量: 327.425
• InChiKey: BPIYPDRFHPLZNO-UHFFFAOYSA-N

物化性质

• 沸点：
  551.8±50.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(4'-methoxy-phenyl)-3-acetoxy-4,4-bis(methylthio)azetidin-2-one 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 1-(4'-methoxy-phenyl)-3-acetoxy-4,4-bis(methylsulfonyl)azetidin-2-one
  参考文献：
  名称：

  4,4-Bis(methylthio)azetidin-2-ones as synthons of 1,2- and 1,3-dicarbonyl systems

  摘要：

  The importance of beta-lactams as synthetic building blocks has been widely recognized in organic synthesis due to possible ring cleavage at any of the four single bonds of the beta-lactam ring. We now report reactions involving breaking of the N1-C4 bond in differently substituted at C3 4,4-bis(methylthio)azetidin-2-ones, leading to formation of 1,2- and 1,3-dicarbonyl systems. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.046
• 作为产物：
  描述：

  dimethyl N-(para-methoxyphenyl)-dithio-carbonimidate 、 乙酰氧基乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-(4'-methoxy-phenyl)-3-acetoxy-4,4-bis(methylthio)azetidin-2-one
  参考文献：
  名称：

  4,4-Bis(methylthio)azetidin-2-ones as synthons of 1,2- and 1,3-dicarbonyl systems

  摘要：

  The importance of beta-lactams as synthetic building blocks has been widely recognized in organic synthesis due to possible ring cleavage at any of the four single bonds of the beta-lactam ring. We now report reactions involving breaking of the N1-C4 bond in differently substituted at C3 4,4-bis(methylthio)azetidin-2-ones, leading to formation of 1,2- and 1,3-dicarbonyl systems. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.046

文献信息

• Bari; Madan; Sethi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 1, p. 10 - 17
  作者：Bari、Madan、Sethi

  DOI：——

  日期：——