2-丙氧基-苯甲酰胺 | 59643-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-丙氧基-苯甲酰胺
• 英文名称: 2-propoxybenzamide
• 英文别名: 2-n-propoxybenzamide
• CAS: 59643-84-4
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD00031465
• 分子量: 179.219
• InChiKey: FAVIQMSTEFBUJX-UHFFFAOYSA-N

物化性质

• 熔点：
  94-96°C
• 沸点：
  311.75°C (rough estimate)
• 密度：
  1.1248 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-丙氧基-苯甲酰胺 以 二氯甲烷 、 Petroleum ether 为溶剂， 生成 3-氨基甲酰基-4-丙氧基苯磺酰氯
  参考文献：
  名称：

  Azapurinones

  摘要：

  该发明提供了一种特定的新型8-azapurin-6-one衍生物，其在2位被取代的苯基团取代，最好是在2位携带烷氧基，具有有价值的药理特性，特别是在治疗由组织固定抗体与特定抗原相互作用所表现的呼吸系统疾病方面。

  公开号：

  US04039544A1
• 作为产物：
  描述：

  水杨酰胺 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以92%的产率得到2-丙氧基-苯甲酰胺
  参考文献：
  名称：

  Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: Study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release

  摘要：

  Benzenesulfonylureas and benzenesulfonylthioureas, as well as benzenecarbonylureas and benzenecarbonylthioureas, were prepared and evaluated as myorelaxants on 30 mM KCl-precontracted rat aortic rings. The most active compounds were further examined as stimulators of elastin synthesis by vascular smooth muscle cells and as inhibitors of insulin release from pancreatic beta-cells. The drugs were also characterized for their effects on glycaemia in rats. Benzenesulfonylureas and benzenesulfonylthioureas did not display any myorelaxant activity on precontracted rat aortic rings. Such an effect could be attributed to their ionization at physiological pH. By contrast, almost all benzenecarbonylureas and benzenecarbonylthioureas displayed a myorelaxant activity, in particular the benzenecarbonylureas with an oxybenzyl group linked to the ortho position of the phenyl ring. The vasodilatory activity of the most active compounds was reduced when measured in the presence of 80 mM KCl or in the presence of 30 mM KCl and 10 mu M glibenclamide. Such results suggested the involvement, at least in part, of K-ATP channels. Preservation of a vasodilatory activity in rat aortic rings without endothelium indicated that the site of action of such molecules was located on the vascular smooth muscle cells and not on the endothelial cells. Some of the most active compounds also stimulated elastin synthesis by vascular smooth muscle cells. Lastly, most of the active vasorelaxant drugs, except 15k and 15t at high concentrations, did not exhibit marked inhibitory effects on the insulin releasing process and on glycaemia, suggesting a relative tissue selectivity of some of these compounds for the vascular smooth muscle. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.02.043

文献信息

• [EN] ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY<br/>[FR] DERIVES D'ARYL-1,3-AZOLE ET PROCEDES PERMETTANT D'INHIBER L'ACTIVITE DE L'HEPARANASE
  申请人：IMCLONE SYSTEMS INC

  公开号：WO2005030206A1

  公开（公告）日：2005-04-07

  The present invention encompasses heparanase inhibitors, particularly to certain 2-substituted heteroaryl-fused and aryl-fused carbazole derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the compounds, and methods of treating heparanase-dependent diseases and conditions in mammals by administering a therapeutically effective amount of the compounds to the mammals.

  本发明涵盖了抑制肝素酶的抑制剂，特别是特定的2-取代杂芳基融合和芳基融合的咔唑衍生物，这些衍生物抑制肝素酶，包含这些化合物的药物组合物，制备这些化合物的方法，以及通过向哺乳动物施用这些化合物的治疗有效量来治疗依赖肝素酶的疾病和病况的方法。
• [EN] ANTIBACTERIAL BENZOIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDES BENZOIQUES ANTIBACTERIENS
  申请人：UPJOHN CO

  公开号：WO2004018428A1

  公开（公告）日：2004-03-04

  The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.

  这项发明提供了抗菌剂和使用这些剂进行哺乳动物的消毒、卫生、防腐、消毒和治疗感染的方法。
• Two Ways of Preparing Benzonitriles Using BrCCl₃–PPh₃ as the Reagent
  作者：Yosef Al Jasem、Mohamed Barkhad、Mona Al Khazali、Hifsa Pervez Butt、Noha Ashraf El-Khwass、Mariam AlAzani、Bassam al Hindawi、Thies Thiemann

  DOI：10.3184/174751914x13891131118347

  日期：2014.2

  Benzamides were converted into benzonitriles with BrCCl₃–PPh₃–Et₃N in CH₂Cl₂ in an Appel-type reaction. Benzaldoximes could be transformed to benzonitriles under identical conditions. It was found that the reaction system BrCCl₃–(2 equiv.)PPh₃ was also suitable for these transformations with PPh₃ replacing Et₃N.

  在 Appel 型反应中，苯甲酰胺与 BrCCl3-PPh3-Et3N 在 CH2Cl2 中转化为苯并腈。在相同的条件下，苯甲醛肟也能转化为苯腈类化合物。研究发现，BrCCl3-(2 等量)PPh3 取代 Et3N 的反应体系也适用于这些转化。
• Method for the control of undesired plant species using
  申请人：American Cyanamid Company

  公开号：US04168964A1

  公开（公告）日：1979-09-25

  This disclosure describes herbicidal methods for the pre- and postemergence control of undesired mono- and dicotyledonous plants using substituted imidazo[1,5-d]-as-triazin-4(3H)-ones and substituted imidazo[1,5-d]-as-triazine-4(3H)-thiones.

  本公开描述了使用取代的咪唑[1,5-d]-嘧啶-4(3H)-酮和取代的咪唑[1,5-d]-嘧啶-4(3H)-硫醚来进行对不受欢迎的单子叶和双子叶植物的前期和后期除草的除草方法。
• Copper-Catalyzed Self-Condensation of Benzamide: Domino Reactions towards Quinazolinones
  作者：Nisar Sayyad、Zamani Cele、Rajeshwar Reddy Aleti、Milan Bera、Srinivasulu Cherukupalli、Balakumar Chandrasekaran、Narva Deshwar Kushwaha、Rajshekhar Karpoormath

  DOI：10.1002/ejoc.201800660

  日期：2018.10.24

  New synthetic method is developed to prepare 2‐substituted 4(3H)‐Quinazolinone using green chemistry technique. It is oxidant and ligand‐free, copper‐catalysed self‐condensation of 2‐halobenzamide.

  开发了一种新的合成方法，以利用绿色化学技术制备2取代的4（3 H）-喹唑啉酮。它是无氧化剂和无配体的铜催化2-卤代苯甲酰胺的自缩合反应。