甲基蒽-1-羧酸盐 | 25308-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 甲基蒽-1-羧酸盐
• 英文名称: methyl anthranylate
• 英文别名: 1-anthracenecarboxylic acid methyl ester；anthracene-1-carboxylic acid methyl ester；Anthracen-1-carbonsaeure-methylester；anthranylic acid methyl ester；Methyl anthracene-1-carboxylate
• CAS: 25308-58-1
• 化学式: C₁₆H₁₂O₂
• 分子量: 236.27
• InChiKey: PXOUANGSUJAJRG-UHFFFAOYSA-N

物化性质

• 熔点：
  103.5-104.0 °C(Solv: methanol (67-56-1))
• 沸点：
  405.4±14.0 °C(Predicted)
• 密度：
  1.208±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  甲基蒽-1-羧酸盐 在 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 生成 1-Chlormethyl-anthracen
  参考文献：
  名称：

  The Alkaline Hydrolysis of Polynuclear Methyl Arylacetates

  摘要：

  DOI：

  10.1021/ja01070a022
• 作为产物：
  描述：

  1-蒽甲酸 在 五氯化磷 作用下， 生成 甲基蒽-1-羧酸盐
  参考文献：
  名称：

  CCLIII。蒽-1-羧酸和-1：5-二羧酸及其衍生物

  摘要：

  DOI：

  10.1039/jr9300001931

文献信息

• Amide derivatives and 5-lipoxygenase inhibitors containing the same as
  申请人：Terumo Corporation

  公开号：US04673684A1

  公开（公告）日：1987-06-16

  According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient. The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC.sub.4 and LTD.sub.4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.

  根据该发明，提供了新型酰胺衍生物和含有该衍生物作为有效成分的5-脂氧合酶抑制剂。该发明中提到的化合物已被证明具有5-脂氧合酶抑制活性。这些化合物可以通过抑制5-脂氧合酶的活性来抑制诸如LTC.sub.4和LTD.sub.4等过敏诱导因子的白三烯产生。因此，酰胺衍生物可用作对过敏性哮喘、过敏性鼻炎等有效的5-脂氧合酶抑制剂。
• Anthranilic acid derivatives
  申请人：Teijin Limited

  公开号：US06649656B1

  公开（公告）日：2003-11-18

  The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

  本发明涉及以下化学式（1）或以下化学式（2）所表示的邻氨基苯甲酸衍生物，或其在药理学上可接受的盐或溶剂化合物。
• Spectroscopic, microscopic and first rheological investigations in charge-transfer interaction induced organogels
  作者：Rajat K. Das、Supratim Banerjee、Guillaume Raffy、André Del Guerzo、Jean-Pierre Desvergne、Uday Maitra

  DOI：10.1039/c0jm01192d

  日期：——

  This article describes two-component charge-transfer interaction mediated organogels (CT-gels) derived from anthracene carboxamides obtained from 2-amino-2-hydroxymethyl-1,3-propanediol (TRIS), and 2,3-dialkoxyanthracenes as donors, with 2,4,7-trinitrofluorenone (TNF) as the common acceptor. We demonstrate the versatility of TNF as an electron acceptor in the formation of these gels. The effect of subtle changes in the donor structure on the gelation ability has been investigated by varying the alkyl chain length in the dialkoxyanthracene donors, and by varying the position of the TRIS substituent in the anthracene carboxamide donors. Distinct differences have been observed in the nature of the CT-gels based on these two kinds of anthracene donors. It has been reported in the literature that 2,3-dialkoxyanthracenes form gels on their own in various aliphatic hydrocarbons and alcohols for linear alkyl chains bearing at least 6 carbon atoms (C6). In the present study, it is shown that the CT-complex of these molecules with TNF is able to gel many alcoholic and a few hydrocarbon solvents. Also, in the presence of TNF, the 2,3-dialkoxyanthracenes (C4–C5) which were non-gelators on their own at ambient temperatures, form CT-gels in a number of alcohols. The other series of gelators discussed, the anthracene carboxamides, require the mandatory presence of TNF to form gels. This donor–acceptor complex forms gels in various aliphatic alcohols. Interestingly, the formation of these CT-gels requires rapid cooling in most of the cases. Thermal stability studies with both types of CT-gels indicate an optimum stoichiometry of 1 : 1 between the donor and the acceptor. Dynamic rheological experiments reveal these gels as viscoelastic soft materials, with the mechanical strength of these gels depending on the amount of TNF present. This provides a means to tune the strength of the gel by varying the doping concentration of the acceptor.

  本文介绍了以 2-氨基-2-羟甲基-1,3-丙二醇（TRIS）和 2,3-二烷氧基蒽为供体，以 2,4,7-三硝基芴酮（TNF）为共同受体的蒽羧酰胺衍生的双组分电荷转移相互作用介导有机凝胶（CT-凝胶）。我们展示了 TNF 作为电子受体在形成这些凝胶过程中的多功能性。通过改变二氧蒽供体中烷基链的长度和蒽羧酰胺供体中 TRIS 取代基的位置，研究了供体结构的微妙变化对凝胶能力的影响。在这两种蒽供体的基础上观察到 CT 凝胶的性质存在明显差异。据文献报道，2,3-二烷氧基蒽在含有至少 6 个碳原子（C6）的线性烷基链的各种脂肪族碳氢化合物和醇中可自行形成凝胶。本研究表明，这些分子与 TNF 的 CT 复合物能够在多种醇类溶剂和少数烃类溶剂中形成凝胶。此外，在 TNF 的存在下，2,3-二烷氧基蒽（C4-C5）在常温下本身是非凝胶体，但在一些醇中却能形成 CT 凝胶。所讨论的另一系列凝胶剂，即蒽羧酰胺，则需要 TNF 的强制存在才能形成凝胶。这种供体-受体复合物可在各种脂肪醇中形成凝胶。有趣的是，这些 CT 凝胶的形成在大多数情况下都需要快速冷却。对这两种 CT 凝胶的热稳定性研究表明，供体和受体之间的最佳化学计量为 1 ：1 的最佳配比。动态流变实验表明，这些凝胶是粘弹性软材料，其机械强度取决于 TNF 的含量。这提供了一种通过改变受体的掺杂浓度来调节凝胶强度的方法。
• Tunable Chiral Reaction Media Based on Two-Component Liquid Crystals: Regio-, Diastereo-, and Enantiocontrolled Photodimerization of Anthracenecarboxylic Acids
  作者：Yasuhiro Ishida、Ammathnadu S. Achalkumar、Shun-ya Kato、Yukiko Kai、Aya Misawa、Yumi Hayashi、Kuniyo Yamada、Yuki Matsuoka、Motoo Shiro、Kazuhiko Saigo

  DOI：10.1021/ja105221u

  日期：2010.12.15

  Three kinds of enantiopure amphiphilic amino alcohols (1a-c) were newly synthesized, of which the stereochemistry of the stereogenic carbons adjacent to the amino (C2) and hydroxy (C1) groups was systematically varied. By using these amino alcohols and four photoreactive carboxylic acids, 12 kinds of salts were prepared. The structure and thermal behavior of the salts were thoroughly investigated by

  新合成了三种对映纯的两亲氨基醇（1a-c），其中与氨基（C2）和羟基（C1）相邻的立体碳的立体化学发生了系统变化。通过使用这些氨基醇和四种光反应性羧酸，制备了12种盐。通过各种技术对盐的结构和热行为进行了深入研究，结果表明氨基醇单元的立体化学对盐的性质有显着影响；具有 (1R,2S)-构型的 1a 的盐没有表现出任何液晶 (LC) 相但显示出高结晶度，而分别具有 (1S,2S)- 和 (1S)-构型的 1b 和 1c 通常提供稳定的具有近晶结构的LC盐。在这些两亲盐的基质中，2-蒽甲酸（2c）和1-蒽甲酸（2d）的原位光二聚反应是通过紫外/可见光（500 W，高压汞弧灯，> 380 nm）照射进行的。关于反应性和区域-/非对映-/对映选择性，发现 LC 相优于各向同性和结晶相。对于两个基板 2c 和 2d，每个 LC 相都以前所未有的高头对头选择性促进了光二聚化。特别是在 2c 的情况下，非对映选择性（syn(HH)
• Photoisomerization and Photocyclization Reactions of 1-Styrylanthracene
  作者：Takashi Karatsu、Akihide Kitamura、Hualing Zeng、Tatsuo Arai、Hirochika Sakuragi、Katsumi Tokumaru

  DOI：10.1246/bcsj.68.920

  日期：1995.3

  1-styrylanthracene (1SA) undergoes adiabatic cis → trans one-way isomerization (3c* → 3t*) similarly to 2-anthrylethylenes. However, upon direct irradiation, cis-1SA in the singlet excited state mostly undergoes cyclization to a dihydrophenanthrene-type product (DHP), 4a,4b-dihydrobenzo[b]chrysene, competing with an inefficient intersystem crossing to 3c* followed by one-way isomerization. The produced DHP, in

  在三线态敏化时，1-苯乙烯基蒽 (1SA) 经历绝热顺式 → 反式单向异构化 (3c* → 3t*)，类似于 2-蒽基乙烯。然而，在直接照射下，处于单线激发态的 cis-1SA 主要经历环化成二氢菲型产物 (DHP)，4a,4b-二氢苯并 [b] 芘，与低效的系统间交叉竞争到 3c*，然后是一个-方式异构化。在脱气苯中产生的 DHP 通过热（Ea = 14.9 kcal mol-1）或光化学途径恢复为 cis-1SA；然而，在含氧气氛下，DHP 会生成苯并 [b] 芘。在反式 1SA 激发下环化产物的生产失败表明异构化确实以单向方式发生。