4-([1,1'-biphenyl]-4-yl)-N-(4-(2,2-diphenylacetamido)butyl)-4-oxobutanamide | 1284259-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-([1,1'-biphenyl]-4-yl)-N-(4-(2,2-diphenylacetamido)butyl)-4-oxobutanamide
• CAS: 1284259-10-4
• 化学式: C₃₄H₃₄N₂O₃
• 分子量: 518.656
• InChiKey: DPCBCZZBDJNDCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.16
• 重原子数：
  39.0
• 可旋转键数：
  13.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  75.27
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  N-(4-azidobutyl)-4-(biphenyl-4-yl)-4-oxobutanamide 在 10% palladium on activated charcoal 、 氢气 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 0.83h， 生成 4-([1,1'-biphenyl]-4-yl)-N-(4-(2,2-diphenylacetamido)butyl)-4-oxobutanamide
  参考文献：
  名称：

  Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries

  摘要：

  The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid butyl amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs were found to have a good anti-tumor activity comparable to cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.068