N,N-diethyl-3-piperidinecarboxamide hydrochloride | 859996-19-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diethyl-3-piperidinecarboxamide hydrochloride
• 英文别名: N,N-diethylpiperidine-3-carboxamide;hydrochloride
• CAS: 859996-19-3
• 化学式: C₁₀H₂₀N₂O*ClH
• 分子量: 220.743
• InChiKey: GKNHHSHPRZOVPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.28
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2,3-di(furan-2-yl)-6-isocyanatoquinoxaline 、 N,N-diethyl-3-piperidinecarboxamide hydrochloride 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-N-[2,3-bis(furan-2-yl)quinoxalin-6-yl]-3-N,3-N-diethylpiperidine-1,3-dicarboxamide
  参考文献：
  名称：

  Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors

  摘要：

  A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay and computational modeling studies showed the compounds were reversible and noncompetitive inhibitors of JSP-1. JSP-1 inhibitors may be useful for the treatment of inflammatory, vascular, neurodegenerative, metabolic, and oncological diseases in humans associated with dysfunctional Jnk signaling. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.094
• 作为产物：
  描述：

  1-BOC-哌啶-3-羧酸 在 盐酸 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 N,N-diethyl-3-piperidinecarboxamide hydrochloride
  参考文献：
  名称：

  Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors

  摘要：

  A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay and computational modeling studies showed the compounds were reversible and noncompetitive inhibitors of JSP-1. JSP-1 inhibitors may be useful for the treatment of inflammatory, vascular, neurodegenerative, metabolic, and oncological diseases in humans associated with dysfunctional Jnk signaling. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.094

文献信息

• A highly efficient Pd–C catalytic hydrogenation of pyridine nucleus under mild conditions
  作者：Chuanjie Cheng、Jimin Xu、Rui Zhu、Lixin Xing、Xinyan Wang、Yuefei Hu

  DOI：10.1016/j.tet.2009.08.011

  日期：2009.10

  A synergistic Pd–C catalytic hydrogenation of 4-pyridinecarboxamides straightforward to 4-piperidinecarboxamide hydrochlorides was developed in the presence of ClCH2CHCl2. It provided a novel strategy for highly efficient hydrogenation of pyridine nuclear by using low-cost Pd–C catalyst under mild conditions.

  在存在ClCH 2 CHCl 2的情况下，开发了对4-吡啶羧甲酰胺盐酸盐直接作用的4-吡啶甲酰胺的Pd-C协同催化氢化反应。它通过在温和条件下使用低成本的Pd-C催化剂，为吡啶核的高效加氢提供了一种新的策略。