1-(4-溴丁氧基)-2-苯基苯 | 53669-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-溴丁氧基)-2-苯基苯
• 英文名称: 2-(4-bromobutoxy)-1,1'-biphenyl
• 英文别名: 2-(4-Bromo-butoxy)-biphenyl；1-(4-Bromobutoxy)-2-phenylbenzene
• CAS: 53669-77-5
• 化学式: C₁₆H₁₇BrO
• mdl: MFCD11546062
• 分子量: 305.214
• InChiKey: CRHHNSOWBZJJEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-溴丁氧基)-2-苯基苯 、 甲胺 以 乙醇 、 水 为溶剂， 反应 13.0h， 以72%的产率得到N-methyl-N.(4-(2-biphenylyloxy)butyl)amine
  参考文献：
  名称：

  Cervena, Irena; Holubek, Jiri; Svatek, Emil, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 7, p. 1966 - 1978

  摘要：

  DOI：
• 作为产物：
  描述：

  dipropyl phenylboronate 在 palladium diacetate 、 sodium hydride 、 sodium carbonate 、 三苯基膦 作用下， 反应 18.5h， 生成 1-(4-溴丁氧基)-2-苯基苯
  参考文献：
  名称：

  Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites

  摘要：

  An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasinodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.033

文献信息

• Studies on Solubilization. (Part I). Note on the synthesis of some quaternary N-(?-aryloxyalkyl) piperidinium, pyridinium, benzyl-dimethyl-ammonium, and trimethyl-ammonium bromides
  作者：R. K. Joshi、L. Krasnec、I. Lacko

  DOI：10.1002/hlca.19710540111

  日期：——

  A series of new N-(ω-aryloxyalkyl) piperidinium, pyridinium, benzyl dimethyl ammonium, and trimethyl ammonium bromides is described.

  描述了一系列新的N-（ω-芳氧基烷基）哌啶，吡啶鎓，苄基二甲基铵和三甲基溴化铵。
• An Efficient Route to 3,3′‐Biindolinylidene‐diones by Iron‐Catalyzed Dimerization of Isatins
  作者：Rahul A. Jagtap、Chandini Pradhan、Rajesh G. Gonnade、Benudhar Punji

  DOI：10.1002/asia.202200414

  日期：2022.8

  Iron(0)-catalyzed self-dimerization and cross-dimerization of isatins is described that provides an easy and efficient access to diverse 3,3′-biindolinylidene-diones

  描述了铁 (0) 催化的靛红的自二聚和交叉二聚，可轻松有效地获得多种 3,3'-联茚亚基二酮
• US4071559A
  申请人：——

  公开号：US4071559A

  公开（公告）日：1978-01-31
• US4074998A
  申请人：——

  公开号：US4074998A

  公开（公告）日：1978-02-21
• Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: Synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites
  作者：Franck Chouteau、David Ramanitrahasimbola、Philippe Rasoanaivo、Kelly Chibale

  DOI：10.1016/j.bmcl.2005.04.033

  日期：2005.6

  An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasinodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series. (c) 2005 Elsevier Ltd. All rights reserved.