N-[2-(4-methoxyphenyl)ethyl]-4-methylaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(4-methoxyphenyl)ethyl]-4-methylaniline
• 英文别名: [2-(4-Methoxy-phenyl)-ethyl]-p-tolyl-amine
• 化学式: C₁₆H₁₉NO
• mdl: MFCD02603500
• 分子量: 241.333
• InChiKey: ZRRBAZPTYVNIAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(p-methoxyphenyl)ethyl benzenesulphonate 、 乙烷,三氯氟- 以 甲醇 为溶剂， 生成 N-[2-(4-methoxyphenyl)ethyl]-4-methylaniline 、 苯磺酸
  参考文献：
  名称：

  甲醇中2-苯乙基苯磺酸酯与苯胺反应的动力学和机理

  摘要：

  研究了在65.0°C下2-苯乙基苯磺酸盐与苯胺在甲醇中的反应动力学。该机构被交叉相互作用常数，ρ的基础上讨论IJ。发现整个反应是通过离解的S N 2机理进行的，其中芳基的参与程度相对较小。亲核辅助途径中，亲核试剂苯胺所捕获的苯离子中间体的分数已显示出随着亲核试剂的增强而增加，并且对于芳基-建议在分子间S N i机理中出现四中心过渡态。无辅助路径。

  DOI：

  10.1039/p29880001537

文献信息

• An (Aminopyrimidinato)titanium Catalyst for the Hydroamination of Alkynes and Alkenes
  作者：Christian Brahms、Patrik Tholen、Wolfgang Saak、Sven Doye

  DOI：10.1002/ejoc.201301004

  日期：2013.11

  (aminopyrimidinato)titanium complex has been synthesised from inexpensive and easily accessible 2-(tert-butylamino)pyrimidine and [Ti(NMe2)4] and used as a catalyst for the intermolecular hydroamination of alkynes as well as the cyclization of aminoalkenes. The hydroamination reactions of 1-phenylpropyne and terminal arylalkynes deliver the corresponding anti-Markovnikov addition products with excellent yields and

  一种新的（氨基嘧啶合）钛络合物已由廉价且易于获得的 2-（叔丁基氨基）嘧啶和 [Ti(NMe2)4] 合成，并用作炔烃分子间加氢胺化以及氨基烯烃环化的催化剂。1-苯基丙炔和末端芳基炔烃的加氢胺化反应以优异的产率和区域选择性提供相应的反马尔科夫尼科夫加成产物。
• Titanium and Zirconium Complexes with Helical Bis(phenolato) Ligands as Hydroamination Catalysts
  作者：Sven Doye、Klaudia Marcseková、Christian Loos、Frank Rominger

  DOI：10.1055/s-2007-986651

  日期：2007.10

  2-cyclohexanediyl backbone can be obtained in two steps from commercially available starting materials. In situ combination of this ligand with Ti(NMe 2 ) 4 or Zr(NMe 2 ) 4 results in the formation of bis(phenolato) complexes that catalyze hydroaminations ofalkynes and alkenes.

  包含反式-1,2-环己二基主链的外消旋双酚 (OSSO) 型配体可以从市售的起始材料中分两步获得。该配体与Ti(NMe 2 ) 4 或Zr(NMe 2 ) 4 的原位组合导致催化炔烃和烯烃的加氢胺化的双(苯酚)络合物的形成。
• GLYCOPEPTIDE COMPOUNDS HAVING ACTIVITY OF RESISTING DRUG-RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
  申请人：Shanghai LaiYi Center For Biopharmaceutical R&D Co., Ltd.

  公开号：EP3763728A1

  公开（公告）日：2021-01-13

  The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema,

  本发明公开了具有抗耐药性细菌活性的糖肽化合物，符合通式（I）所代表的糖肽化合物、 本发明还提供了糖肽化合物的制备方法和应用。经测试，与第二代糖肽药物奥利他万星（oritavancin）相比，糖肽抗生素化合物对耐药菌株，尤其是 MRSA 或 VRE 具有更高的抑制活性。进一步的测试表明，大多数糖肽化合物的安全性高于奥利他万星，可以制备成药物，用于治疗或预防各种细菌感染引起的疾病，如皮肤和软组织感染、脑膜炎、败血症、肺炎、关节炎、腹膜炎、支气管炎和肺水肿、
• Glycopeptide Compounds Having Activity Of Resisting Drug-Resistant Bacteria, And Preparation Method And Application Thereof
  申请人：Shanghai LaiYi Center For Biopharmaceutical R&D Co

  公开号：US20210093691A1

  公开（公告）日：2021-04-01

  The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.
• Kinetics and mechanism of reactions between 2-phenylethyl benzenesulphonates and anilines in methanol
  作者：Ikchoon Lee、Yong Hoon Choi、Hai Whang Lee、Byung Choon Lee

  DOI：10.1039/p29880001537

  日期：——

  Kinetics of reactions between 2-phenylethyl benzenesulphonates and anilines in methanol at 65.0 °C have been studied; the mechanism is discussed on the basis of cross interaction constants, ρij. The overall reaction was found to proceed by a dissociative SN2 mechanism with a relatively small degree of aryl participation. The fraction of the phenonium ion intermediate captured by the nucleophile, aniline

  研究了在65.0°C下2-苯乙基苯磺酸盐与苯胺在甲醇中的反应动力学。该机构被交叉相互作用常数，ρ的基础上讨论IJ。发现整个反应是通过离解的S N 2机理进行的，其中芳基的参与程度相对较小。亲核辅助途径中，亲核试剂苯胺所捕获的苯离子中间体的分数已显示出随着亲核试剂的增强而增加，并且对于芳基-建议在分子间S N i机理中出现四中心过渡态。无辅助路径。