2-benzyloxy-N-(p-hydroxyphenyl)acetamide | 901451-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyloxy-N-(p-hydroxyphenyl)acetamide
• 英文别名: 2-Benzyloxy-N-(4-hydroxy-phenyl)-acetamide；N-(4-hydroxyphenyl)-2-phenylmethoxyacetamide
• CAS: 901451-04-5
• 化学式: C₁₅H₁₅NO₃
• mdl: MFCD25459216
• 分子量: 257.289
• InChiKey: SDLUGEVANSVULP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-benzyloxy-N-(p-hydroxyphenyl)acetamide 在 钯 氢气 、 甲醇 、 chloroform methanol 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以to get pure 27 (4 grams, 34.2%) as的产率得到2-hydroxy-N-(4-hydroxyphenyl)acetamide
  参考文献：
  名称：

  Functionalized drugs and polymers derived therefrom

  摘要：

  从中选择的化合物：其中DRUG-OH，DRUG-COOH和DRUG-NH2是生物活性化合物；每个X独立地从-CH2COO-（乙二酸醇基），-CH（CH3）COO-（乳酸醇基），-CH2CH2OCH2COO-（二氧杂环己酮基），-CH2CH2CH2CH2CH2COO-（己内酯基），-（CH2）yCOO-中选择，其中y为2-4或6-24，以及-（CH2CH2O）zCH2COO-，其中z为2-24；每个Y独立地从-COCH2O-（乙二酸酯基），-COCH（CH3）O-（乳酸酯基），-COCH2OCH2CH2O-（二氧杂环己酮酯基），-COCH2CH2CH2CH2CH2O-（己内酯酯基），-CO（CH2）mO-中选择，其中m为2-4或6-24，以及-COCH2O（CH2CH2O）n-，其中n在2-24之间；R'为氢，苄基或烷基，烷基可以是直链或支链；p为1-6。还披露了多功能化合物和药物二聚体，寡聚体和聚合物。

  公开号：

  US07691364B2
• 作为产物：
  描述：

  Benzyloxyacetic acid-4-(2-benzyloxyacetylamino)phenyl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 13.0h， 以5.90 g的产率得到2-benzyloxy-N-(p-hydroxyphenyl)acetamide
  参考文献：
  名称：

  Affinity purification and characterization of a key enzyme responsible for circadian rhythmic control of nyctinasty in Lespedeza cuneata L

  摘要：

  The synthesis of an affinity gel aimed at leaf-opening factor beta-glucosidase (LOFG) and affinity purification of LOFG is presented. A gluconamidine-based beta-glucosidase inhibitor was used as the ligand of the affinity gel. beta-Glucosidase exhibiting an activity shift throughout the day was selectively purified from Lespedeza cuneata Don by the affinity gel. The resulting LOFG exhibited high substrate specificity toward the leaf-opening factor. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.02.035

文献信息

• Functionalized phenolic esters and amides and polymers therefrom
  申请人：Bezwada S. Rao

  公开号：US20060173065A1

  公开（公告）日：2006-08-03

  The present invention relates to a compound of the formula: R-AR—O—Y—R′ Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO 2 , —NH 2 , —NHCOCH 3 , and —NH—Y—R′, which is attached directly to AR or attached through an aliphatic chain. The carboxylic acid moiety in R includes but is not limited to the following carboxylic acids: benzoic acids, cinnamic acids, ferulic acid, caffeic acid, syringic acid, salicylic acid, vanillic acid, phenylacetic acids, phenylpropionic acids, and sinapinic acid. -AR—O— is a biologically active phenolic moiety comprising 1 to 6 substituted or unsubstituted aryl rings that are directly bonded to each other, fused together, or joined through a linking group. Y represents a member selected from: —COCH 2 O— (glycolic ester moiety) —COCH(CH 3 )O— (lactic ester moiety) —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety) —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety) —CO(CH 2 ) m O— where m is an integer between 2-4 and 6-24 inclusive —COCH 2 O(CH 2 CH 2 O) n — where n is an integer between 2 and 24, inclusive; and R′ is either hydrogen or a benzyl or an alkyl group, the alkyl group being either straight-chained or branched. The resultant functionalized phenolic compounds, used singly or in combinations, and their polymers have controllable degradation profiles, releasing the active component over a desired time range. The polymers are useful for biomaterials and biomedical devices, wherein said biologically active phenolic moiety is a residue of a phenolic compound.

  本发明涉及一种化合物，其化学式为：R-AR—O—Y—R′，其中R代表从H、烷氧基、苯甲氧基、醛基、卤素、羧酸、—NO2、—NH2、—NHCOCH3和—NH—Y—R′中选择的一个或多个成员，该成员直接附着在AR上或通过脂肪链连接。R中的羧酸基团包括但不限于以下羧酸：苯甲酸、肉桂酸、阿魏酸、咖啡酸、槲皮酸、水杨酸、香草酸、苯乙酸、苯丙酸和芥子酸。-AR—O—是一个生物活性的酚基团，包括1到6个取代或未取代的芳香环直接连接、融合或通过连接基团连接的环。Y代表从以下成员中选择：—COCH2O—（乙二醇酯基团）—COCH(CH3)O—（乳酸酯基团）—COCH2OCH2CH2O—（二氧环酮酯基团）—COCH2CH2CH2CH2CH2O—（己内酯酯基团）—CO(CH2)mO—其中m是2-4和6-24之间的整数—COCH2O(CH2CH2O)n—其中n是2到24之间的整数；R′是氢或苄基或烷基，烷基可以是直链或支链。所得的功能化酚类化合物单独或组合使用，其聚合物具有可控的降解特性，释放所需时间范围内的活性成分。该聚合物对于生物材料和生物医学器械有用，其中所述的生物活性酚基团是酚类化合物的残留物。
• FUNCTIONALIZED DRUGS AND POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20100152272A1

  公开（公告）日：2010-06-17

  Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH 2 are biologically active compounds; each X is independently selected from —CH 2 COO— (glycolic acid moiety), —CH(CH 3 )COO— (lactic acid moiety), —CH 2 CH 2 OCH 2 COO— (dioxanone moiety), —CH 2 CH 2 CH 2 CH 2 CH 2 COO— (caprolactone moiety), —(CH 2 ) y COO—, where y is 2-4 or 6-24 and —(CH 2 CH 2 O) z CH 2 COO—, where z is 2-24; each Y is independently selected from —COCH 2 O— (glycolic ester moiety), —COCH(CH 3 )O— (lactic ester moiety), —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety), —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety), —CO(CH 2 ) m O—, where m is 2-4 or 6-24 and —COCH 2 O(CH 2 CH 2 O) n — where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.

  所选化合物包括：DRUG-OH，DRUG-COOH和DRUG-NH2是具有生物活性的化合物；每个X独立选择自—CH2COO—（乙二酸酯基），—CH(CH3)COO—（乳酸酯基），—CH2CH2OCH2COO—（二氧杂环己酮酯基），—CH2CH2CH2CH2CH2COO—（己内酯酯基），—（CH2）yCOO—，其中y为2-4或6-24和—（CH2CH2O）zCH2COO—，其中z为2-24；每个Y独立选择自—COCH2O—（乙二酸酯基），—COCH(CH3)O—（乳酸酯基），—COCH2OCH2CH2O—（二氧杂环己酮酯基），—COCH2CH2CH2CH2CH2O—（己内酯酯基），—CO（CH2）mO—，其中m为2-4或6-24和—COCH2O（CH2CH2O）n—，其中n为2-24；R'为氢，苄基或烷基，所述烷基可以是直链或支链；p为1-6。还公开了多功能化合物和药物二聚体、寡聚体和聚合物。
• FUNCTIONALIZED PHENOLIC ESTERS AND AMIDES AND POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20110130448A1

  公开（公告）日：2011-06-02

  The present invention relates to a compound of the formula: R-AR—O—Y—R′ Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO 2 , —NH 2 , —NHCOCH 3 , and —NH—Y—R′, which is attached directly to AR or attached through an aliphatic chain. The carboxylic acid moiety in R includes but is not limited to the following carboxylic acids: benzoic acids, cinnamic acids, ferulic acid, caffeic acid, syringic acid, salicyclic acid, vanillic acid, phenylacetic acids, phenylpropionic acids, and sinapinic acid. -AR—O— is a biologically active phenolic moiety comprising 1 to 6 substituted or unsubstituted aryl rings that are directly bonded to each other, fused together, or joined through a linking group. Y represents a member selected from: —COCH 2 O— (glycolic ester moiety) —COCH(CH 3 )O— (lactic ester moiety) —COCH 2 OCH 2 CH 2 O— (dioxanone ester moiety) —COCH 2 CH 2 CH 2 CH 2 CH 2 O— (caprolactone ester moiety) —CO(CH 2 ) m O— where m is an integer between 2-4 and 6-24 inclusive —COCH 2 —O—(CH 2 CH 2 O) n — where n is an integer between 2 and 24, inclusive; and R′ is either hydrogen or a benzyl or an alkyl group, the alkyl group being either straight-chained or branched. The resultant functionalized phenolic compounds, used singly or in combinations, and their polymers have controllable degradation profiles, releasing the active component over a desired time range. The polymers are useful for biomaterials and biomedical devices, wherein said biologically active phenolic moiety is a residue of a phenolic compound.

  本发明涉及以下式的化合物：R-AR-O-Y-R′其中R代表从H、烷氧基、苯甲氧基、醛基、卤素、羧酸、-NO2、-NH2、-NHCOCH3和-NH-Y-R′中选择的一个或多个成员，它们直接连接到AR或通过脂肪链连接。R中的羧酸基团包括但不限于以下羧酸：苯甲酸、肉桂酸、香豆酸、咖啡酸、槲皮酸、水杨酸、香草酸、苯乙酸、苯丙酸和芥子酸。-AR-O-是一个生物活性酚基团，包括1至6个取代或未取代的芳环，它们直接连接在一起，融合在一起或通过连接基团连接在一起。Y代表从以下成员中选择：-COCH2O-（乙二醇酯基团）、-COCH（CH3）O-（乳酸酯基团）、-COCH2OCH2CH2O-（二氧杂环酮酯基团）、-COCH2CH2CH2CH2CH2O-（己内酯酯基团）、-CO（CH2）mO-其中m是2-4和6-24之间的整数，-COCH2-O-（CH2CH2O）n-其中n是2至24之间的整数；以及R′是氢或苄基或烷基，烷基可以是直链或支链。所得的功能化酚化合物，单独或组合使用，及其聚合物具有可控的降解特性，可以在所需的时间范围内释放活性成分。这些聚合物对于生物材料和生物医学器件非常有用，其中所述的生物活性酚基团是酚化合物的残基。
• USRE045548E1
  申请人：——

  公开号：——

  公开（公告）日：——
• FUNCTIONALIZED DRUGS AND POLYMERS DERIVED THEREFROM
  申请人：Bezwada Biomedical LLC

  公开号：EP1931334A2

  公开（公告）日：2008-06-18