N-丁基-D-谷氨酰胺 | 18375-57-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-丁基-D-谷氨酰胺
• 英文名称: n-butyl-D-gluconamide
• 英文别名: D-Gluconamido-n-butan；(2R,3S,4R,5R)-N-butyl-2,3,4,5,6-pentahydroxyhexanamide
• CAS: 18375-57-0
• 化学式: C₁₀H₂₁NO₆
• 分子量: 251.28
• InChiKey: CRYAIAMXDBHCTJ-LURQLKTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  130
• 氢给体数：
  6
• 氢受体数：
  6

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-丁基-D-谷氨酰胺 、 苯硼酸 以 甲苯 为溶剂， 反应 6.0h， 以88%的产率得到
  参考文献：
  名称：

  Orthogonal construction of dual dynamic covalent linkages toward an “AND” logic-gate acid-/salt-responsive block copolymer

  摘要：

  A novel block copolymer is fabricated by orthogonally coupling two end-functionalized polymers, glucose-capped methoxypoly(ethylene glycol) (mPEG(2k)-diol) and phenylboronic acid-capped poly(epsilon-caprolactone) (PBA-PCL), with dual boronate ester and B-N/B-O dynamic covalent interactions. Due to their synergetic effect, this block copolymer can self-assemble into micelles in aqueous solution with high stability. More importantly, micellar disassembly can be only triggered in the presence of both signal inputs, acid and salt, displaying an "AND" logic-gate responsive behavior.

  DOI：

  10.1016/j.polymer.2018.11.014
• 作为产物：
  描述：

  正丁胺 、 葡萄糖酸内酯 以 甲醇 为溶剂， 反应 24.0h， 以72%的产率得到N-丁基-D-谷氨酰胺
  参考文献：
  名称：

  Orthogonal construction of dual dynamic covalent linkages toward an “AND” logic-gate acid-/salt-responsive block copolymer

  摘要：

  A novel block copolymer is fabricated by orthogonally coupling two end-functionalized polymers, glucose-capped methoxypoly(ethylene glycol) (mPEG(2k)-diol) and phenylboronic acid-capped poly(epsilon-caprolactone) (PBA-PCL), with dual boronate ester and B-N/B-O dynamic covalent interactions. Due to their synergetic effect, this block copolymer can self-assemble into micelles in aqueous solution with high stability. More importantly, micellar disassembly can be only triggered in the presence of both signal inputs, acid and salt, displaying an "AND" logic-gate responsive behavior.

  DOI：

  10.1016/j.polymer.2018.11.014

文献信息

• Small molecule ice recrystallization inhibitors and methods of use thereof
  申请人：THE UNIVERSITY OF OTTAWA

  公开号：US10004222B2

  公开（公告）日：2018-06-26

  Ice recrystallization inhibitor (IRI) compounds and methods for cryopreserving umbilical cord blood are provided. The compounds are unsubstituted, mono-substituted, or di-substituted aryl-aldonamides. The methods include fractionating whole umbilical cord blood to generate a fraction comprising hematopoietic stem cells, mixing the hematopoietic stem cells with at least one IRI compound to form an IRI suspension, and freezing the IRI suspension.

  本研究提供了用于冷冻保存脐带血的冰再结晶抑制剂（IRI）化合物和方法。这些化合物是未取代的、单取代的或双取代的芳基-醛酰胺类化合物。这些方法包括分馏整个脐带血以产生包含造血干细胞的部分，将造血干细胞与至少一种IRI化合物混合以形成IRI悬浮液，并冷冻IRI悬浮液。
• Synthesis and evaluation of d-gluconamides as green mineral scales
  作者：Marcelo I.P. Reis、Aline D. Gonçalves、Fernando de C. da Silva、Alessandro K. Jordão、Ricardo J. Alves、Saulo Fernandes de Andrade、Jackson A.L.C. Resende、Anderson A. Rocha、Vitor F. Ferreira

  DOI：10.1016/j.carres.2012.01.027

  日期：2012.5

  A series of 13 D-gluconamides were synthesized in moderate to good yields and evaluated as green scale inhibitors. The crystal structures of two compounds were determined by X-ray crystallography. The compounds 6c and 6d showed a reasonable inhibition of BaSO4 precipitation from aqueous solution (47% and 51%, respectively) that indicated the potential for these derivatives of delta-gluconolactone. (C) 2012 Elsevier Ltd. All rights reserved.
• SMALL MOLECULE ICE RECRYSTALLIZATION INHIBITORS AND METHODS OF USE THEREOF
  申请人：THE UNIVERSITY OF OTTAWA

  公开号：US20150157010A1

  公开（公告）日：2015-06-11

  The invention relates to small molecule ice recrystallization inhibitor (IRI) compounds having increased ice recrystallization inhibition activity. The IRI compounds disclosed herein are useful in compositions, kits and methods for cryopreserving biological material such as organs, tissues and cells.
• Small Molecule Ice Recrystallization Inhibitors And Methods Of Use Thereof
  申请人：THE UNIVERSITY OF OTTAWA

  公开号：US20150373968A1

  公开（公告）日：2015-12-31

  Ice recrystallization inhibitor (IRI) compounds and methods for cryopreserving umbilical cord blood are provided. The compounds are unsubstituted, mono-substituted, or di-substituted aryl-adlonamides. The methods include fractionating whole umbilical cord blood to generate a fraction comprising hematopoietic stem cells, mixing the hematopoietic stem cells with at least one IRI compound to form an IRI suspension, and freezing the IRI suspension.
• VANCOMYCIN-SUGAR CONJUGATES AND USES THEREOF
  申请人：JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (JNCASR)

  公开号：US20160303184A1

  公开（公告）日：2016-10-20

  The present disclosure relates to vancomycin-sugar conjugates, its stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of the vancomycin-sugar conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases mediated by bacteria.