N-十六烷基-D-谷氨酰胺 | 18375-65-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-十六烷基-D-谷氨酰胺
• 英文名称: 2,3,4,5,6-pentahydroxyhexanoic acid hexadecylamide
• 英文别名: N-(1-hexadecyl)-D-gluconamide；N-hexadecyl-D-gluconamide；N-Hexadecyl-D-gluconamid；D-Gluconsaeure-hexadecylamid；N-hexadecyl Gluconamide；D-Gluconamido-n-hexadecan；N-Hexadecyl-D-gluconamide；(2R,3S,4R,5R)-N-hexadecyl-2,3,4,5,6-pentahydroxyhexanamide
• CAS: 18375-65-0
• 化学式: C₂₂H₄₅NO₆
• 分子量: 419.602
• InChiKey: BAQZGMGRUAWPCJ-MXEMCNAFSA-N

物化性质

• 沸点：
  676.0±55.0 °C(Predicted)
• 密度：
  1.085±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  130
• 氢给体数：
  6
• 氢受体数：
  6

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-十六烷基-D-谷氨酰胺 、 棕榈酰氯 以 氯仿 为溶剂， 反应 20.0h， 生成 hexadecanoic acid-5-hexadecylcarbamoyl-2,3,4,5-tetrahydroxypentyl ester
  参考文献：
  名称：

  유사 세라마이드 화합물, 이의 제조방법 및 이를 포함하는 화장료 조성물

  摘要：

  The resulting similar ceramide compound is represented by the chemical formula 1 by introducing alkylamine and acylglycine into D-glucosamine. Here, A represents a solution of gluconic acid or gluconic acid, R represents a straight or branched alkyl group having 10 to 22 carbon atoms, R represents a straight or branched alkyl group having 11 to 21 carbon atoms, or a straight or branched alkenyl group having 11 to 21 carbon atoms.

  公开号：

  KR20180025062A
• 作为产物：
  描述：

  十六胺 、 葡糖酸 以 苯 为溶剂， 反应 24.0h， 生成 N-十六烷基-D-谷氨酰胺
  参考文献：
  名称：

  유사 세라마이드 화합물, 이의 제조방법 및 이를 포함하는 화장료 조성물

  摘要：

  The resulting similar ceramide compound is represented by the chemical formula 1 by introducing alkylamine and acylglycine into D-glucose. Here, A is a gluconic acid or gluconic acid solution, R is a straight or branched alkyl group with a carbon number of 10 to 22, R is a straight or branched alkyl group with a carbon number of 11 to 21, or a straight or branched alkyl group with a carbon number of 11 to 21.

  公开号：

  KR20180057875A

文献信息

• Direct Amidation of Aldoses and Decarboxylative Amidation of α-Keto Acids: An Efficient Conjugation Method for Unprotected Carbohydrate Molecules
  作者：Chia-Ching Cho、Jia-Nan Liu、Chung-Hsun Chien、Jiun-Jie Shie、Ying-Chu Chen、Jim-Min Fang

  DOI：10.1021/jo802338k

  日期：2009.2.20

  With use of iodine as an appropriate oxidant, unprotected and unmodified aldoses undergo oxidative amidation with a variety of functionalized amines, α-amino esters, and peptides, whereas KDO, sialic acid, and other α-keto acids proceed with oxidative decarboxylation followed by in situ amidation. Glycoside bond and many other functional groups are inert under such mild reaction conditions. This reaction

  通过使用碘作为适当的氧化剂，未保护和未修饰的醛糖会与各种功能化的胺，α-氨基酯和肽进行氧化酰胺化，而KDO，唾液酸和其他α-酮酸会继续进行氧化脱羧反应原位酰胺化。在这种温和的反应条件下，糖苷键和许多其他官能团是惰性的。用于糖分子的直接连接的该反应方案在糖缀合物的一般和有效合成的发展中看起来是有希望的。
• Biospecific emulsions
  申请人：Chesebrough-Pond's USA Co., Division of Conopco, Inc.

  公开号：US05416075A1

  公开（公告）日：1995-05-16

  Oil-in-water emulsions can be formed using surfactants with biospecific headgroups. Emulsion droplets adhere to surfaces of microorganisms or to various biological surface bearing appropriate adhesins, thus delivering surfactant materials directly to various surfaces. Lipophilic materials and essential oils can be targeted in this way. The emulsions may be incorporated into oral hygiene non-food compositions or compositions for topical application to skin, hair or nails.

  使用具有生物特异性头基的表面活性剂可以形成油包水乳液。乳液微滴附着在微生物表面或各种生物表面上，带有适当的黏附素，从而将表面活性剂材料直接输送到各种表面。这种方法可以针对亲脂性材料和精油。这些乳液可以被纳入口腔卫生非食品组合物或用于皮肤、头发或指甲的局部应用组合物中。
• Micelle-mediated multicomponent cross-coupling in water: general construction of 3-chalcogenylindoles
  作者：Xi He、Weili Song、Xuemin Liu、Jiamin Huang、Ruilong Feng、Shaodong Zhou、Jianquan Hong、Xin Ge

  DOI：10.1039/d2gc03694k

  日期：——

  A general and sustainable multicomponent cross-coupling for the construction of 3-chalcogenylindoles from indoles with aryl iodides and elemental sulfur under the aqueous micellar condition was developed. Elemental sulfur is employed as an eco-friendly and easy-handling sulfur source of thiyl radicals. The synergic effect between Cu catalysts and micelles formed by the sugar-based surfactant GluM can

  开发了一种通用且可持续的多组分交叉偶联，用于在水性胶束条件下从吲哚与芳基碘化物和元素硫构建 3-硫属吲哚。元素硫被用作一种环保且易于处理的硫自由基硫源。Cu 催化剂和糖基表面活性剂 GluM 形成的胶束之间的协同作用可以稳定硫自由基，进一步通过单电子转移在容易获得的吲哚上引发 C-S 偶联。值得注意的是，水性胶束系统不仅可以回收再利用，收率高，而且还可以扩展到元素硒的转化。
• Synthetic Emulsifying Agents
  作者：Mary Fieser、Louis F. Fieser、Edmond Toromanoff、Yoshimasa Hirata、Hans Heymann、Melvin Tefft、Sivaprasad Bhattacharya

  DOI：10.1021/ja01593a049

  日期：1956.6
• Mehltretter et al., Journal of the American Oil Chemists' Society, 1952, vol. 29, p. 202
  作者：Mehltretter et al.

  DOI：——

  日期：——