2-Methoxyphenazin-5,10-dioxid | 303-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Methoxyphenazin-5,10-dioxid
• 英文别名: 2-methoxy-phenazine 5,10-dioxide；2-Methoxy-phenazin-5,10-dioxid；2-Methoxyphenazin-N,N'-dioxid；2-Methoxyphenazin-di-N-oxid；2-Methoxyphenazine, 5,10-dioxide；2-methoxy-10-oxidophenazin-5-ium 5-oxide
• CAS: 303-78-6
• 化学式: C₁₃H₁₀N₂O₃
• 分子量: 242.234
• InChiKey: KEQNUKOWWOSBSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,5-二羟基苯甲酸 在 sodium hydroxide 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-Methoxyphenazin-5,10-dioxid
  参考文献：
  名称：

  Roemer, A.; Sammet, M., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983, vol. 38, # 7, p. 866 - 872

  摘要：

  DOI：

文献信息

• Substituted phenazines and methods of treating cancer and bacterial diseases
  申请人：Rongved Pål

  公开号：US11046678B2

  公开（公告）日：2021-06-29

  Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.

  式 (Ia) 或 (Ib) 的化合物，或其药学上可接受的盐、 包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。
• Rosum; Kiprianow, Zhurnal Obshchei Khimii, 1959, vol. 29, p. 1306,1310; engl. Ausg. S. 1278, 1281
  作者：Rosum、Kiprianow

  DOI：——

  日期：——
• Otomasu et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1964, vol. 84, p. 1080,1083
  作者：Otomasu et al.

  DOI：——

  日期：——
• N-OXIDE HETEROCYCLES FOR USE IN THE TREATMENT OF CANCER AND BACTERIAL DISEASES
  申请人：Rongved, Pål

  公开号：EP3555052A1

  公开（公告）日：2019-10-23
• COMPOUNDS
  申请人：RONGVED Pål

  公开号：US20200095237A1

  公开（公告）日：2020-03-26

  The invention provides compounds of general formula (I′), and their pharmaceutically acceptable salts: wherein: Z is a group having the formula: -T-S-A-Y in which: T is a group selected from —O—, —NH—, —S—, —(XCR 7 R 8 )— (where R 7 and R 8 is independently —H or C 1-3 alkyl and X is selected from from —O—, —NH—, —S—); S is —(C═O)—, —(SO 2 )—, —(PO 2 )—; A, —O—, —NH—, —S— or —NH(CO)—, —(CR 7 R 8 X)— (where R 7 and R 8 is independently —H or C 1-3 alkyl and X is selected from from —O—, —NH—, —S—), -T-S-A- is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to leave a group selected from —OH, —NH 2 , —SH, —COOH, —CONH 2 , —O—(CR 7 R 8 )—COOH and —(CR 7 R 8 )—CONH 2 ; Y is one or more targeting groups or a lipophilic or hydrophilic group affecting the solubility in water and the biodistribution in a living organism or a living cell; R 1 -R 6 are independently selected from hydrogen, halogen (e.g. F, Cl, Br, I), lower alkyl (e.g. C 1-6 alkyl), optionally substituted with an acidic group which is —COOH, —SO 3 H, —PO 3 H 2 or —B(OH) 2 . Such compounds find particular use as anti-neoplastic and anti-infective agents.

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