9-acetoxymethylfluorene | 63839-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-acetoxymethylfluorene
• 英文别名: fluoren-9-ylmethyl acetate；(9H-fluoren-9-yl)methyl acetate；9H-Fluorene-9-methanol, acetate；9H-fluoren-9-ylmethyl acetate
• CAS: 63839-86-1
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: PJSNQCAWMYREAY-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于二氯甲烷、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915390090

反应信息

• 作为反应物：
  描述：

  9-acetoxymethylfluorene 在 potassium tert-butylate 作用下， 以 乙醚 、 Petroleum ether 为溶剂， 生成 9-亚甲基芴
  参考文献：
  名称：

  苯并富勒烯和二苯并富勒烯1-乙酸氯烷基酯的合成† ‡

  摘要：

  通过1-氯烷基乙酸酯合成苯并富烯和二苯并富烯

  DOI：

  10.1002/hlca.19770600332
• 作为产物：
  描述：

  9-芴甲醇 以87%的产率得到
  参考文献：
  名称：

  LIU, YIN-ZENG;DING, SHAO-HUA;CHU, JI-YU;FELIX, ARTHUR M., INT. J. PEPTIDE AND PROTEIN RES., 35,(1990) N, C. 95-98

  摘要：

  DOI：

文献信息

• CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF
  申请人：PFIZER INC.

  公开号：US20130129753A1

  公开（公告）日：2013-05-23

  The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

  本发明涉及细胞毒性五肽，其抗体药物偶联物，以及使用它们治疗癌症的方法。
• [EN] CELL CULTURE SUBSTRATES<br/>[FR] SUBSTRATS DE CULTURE CELLULAIRE
  申请人：UNIV MACQUARIE

  公开号：WO2019033171A1

  公开（公告）日：2019-02-21

  The present application describes a class of peptides comprising from (2) to (12) amino acid residues, wherein: the N-terminus of the peptide is linked to an optionally substituted, fused polycyclic group comprising an aromatic ring; at least one amino acid residue has a hydrophobic side chain; at least two amino acid residues have a cation-containing side chain, or at least one amino acid residue has two or more cation-containing side chains, or at least one amino acid residue has one or more side chains comprising two or more cations; and the net charge of the peptide is positive at a pH of from about (4) to about (10). The present application also describes hydrogels and cell culture substrates comprising the peptides, as well as the use of the cell culture substrates for culturing cells.

  本申请描述了一类肽，包括（2）到（12）个氨基酸残基，其中：肽的N-末端与一个可选择替代的、融合的多环芳香环团相连；至少一个氨基酸残基具有疏水侧链；至少两个氨基酸残基具有含阳离子的侧链，或者至少一个氨基酸残基具有两个或更多含阳离子的侧链，或者至少一个氨基酸残基具有一个或多个含有两个或更多阳离子的侧链；并且在约为（4）到约为（10）的pH下，肽的净电荷为正。本申请还描述了包含这些肽的水凝胶和细胞培养基质，以及利用细胞培养基质培养细胞的用途。
• COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
  申请人：Whitten Jeffrey P.

  公开号：US20110263612A1

  公开（公告）日：2011-10-27

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文描述了含有这些化合物的化合物和药物组合物，这些化合物调节储存操作钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂的方法，单独或与其他化合物结合，用于治疗需要抑制SOC通道活性的疾病或症状。
• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• NUCLEIC ACID MONOMERS WITH 2'-CHEMICAL MOIETIES
  申请人：Laikhter Andrei

  公开号：US20070218490A1

  公开（公告）日：2007-09-20

  The invention provides nucleic acid monomers with a 2′-modification that are useful for the incorporation of dyes or blocking groups. The monomers can be incorporated on the 3′-end of a dual labeled probe to inhibit PCR polymerase extension during PCR. The polymerase is inhibited from extending the probe at the 3′-hydroxyl group when the monomer is present; there is no need to add a chemical moiety to the 3′-hydroxyl or remove the 3′-hydroxyl. The monomers can also be incorporated internally or at the 5′-end of the oligonucleotide. A detectable label, such as a fluorescent or quenching dye, can be incorporated on the 2′-position of such monomers.

  该发明提供了具有2'-修饰的核酸单体，可用于染料或阻断基团的引入。这些单体可以被合并到双标记探针的3'-末端，以在PCR过程中抑制PCR聚合酶的延伸。当单体存在时，聚合酶被抑制在3'-羟基团上延伸探针；无需向3'-羟基团添加化学基团或去除3'-羟基团。这些单体也可以在寡核苷酸的内部或5'-末端进行合并。可以在这些单体的2'-位置上合并可检测的标记，如荧光染料或猝灭染料。