2-(4-acetamidophenoxy)ethyl chloride | 36616-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-acetamidophenoxy)ethyl chloride
• 英文别名: N-<4-(2-chloroethoxy)phenyl>ethanamide；N-[4-(2-chloroethoxy)phenyl]acetamide；4-(2-chloro-ethoxy)-acetanilide；acetic acid-[4-(2-chloro-ethoxy)-anilide]；Essigsaeure-[4-(2-chlor-aethoxy)-anilid]；4-Acetamino-phenol-(β-chlor-aethylaether)；N-(4-(2-Chloroethoxy)phenyl)acetamide
• CAS: 36616-28-1
• 化学式: C₁₀H₁₂ClNO₂
• 分子量: 213.664
• InChiKey: HLLURZQGVBWFRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-(4-acetamidophenoxy)ethyl chloride 在 盐酸 、 甲苯 作用下， 生成 4-(2-哌啶-1-乙氧基)-苯胺
  参考文献：
  名称：

  THE SYNTHESIS OF SOME ACETYLAMINO-PHENOXYETHYLAMINES¹

  摘要：

  DOI：

  10.1021/jo01138a012
• 作为产物：
  描述：

  N-[4-(羟基乙氧基)苯基]乙酰胺 在 氯化亚砜 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 2-(4-acetamidophenoxy)ethyl chloride
  参考文献：
  名称：

  3,8-Diazabicyclo-[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent

  摘要：

  Ambasilide, a representative of Class III antiarrhythmics, was reported to prolong the cardiac action potential duration in the dog, with little or no effect on Ca and Na currents. We synthesised a series of ambasilide analogues, having the 3,8-diazabicyclo-[3.2.1]-octane moiety instead of the 3,7-diazabicyclo-[3.3.1]-nonane present in ambasilide. The compounds were tested both in vitro extracellular electrophysiological assays and by the conventional microelectrode technique. Most of them lengthened the effective refractory period (ERP) with no change or slight increase on the impulse conduction time (ICT). Similarly some of the tested compounds lengthened the action potential duration (APD), a typical Class III feature, without exerting any significant effect on the maximal rate of depolarization, therefore apparently lacking Class I antiarrythmic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01246-6

文献信息

• [EN] ARYLGLYCINE DERIVATIVES FOR USE AS GLYCINE TRANSPORT INHIBITORS<br/>[FR] DERIVES D'ARYLGLYCINE UTILISABLES COMME INHIBITEURS DE TRANSPORT DE GLYCINE
  申请人：NPS ALLELIX CORP

  公开号：WO2004022534A1

  公开（公告）日：2004-03-18

  The present invention relates to compounds of Formula (I) and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological and neuropsychistric disorders using said compounds.

  本发明涉及式(I)的化合物及其盐、溶剂化物和水合物。该发明进一步涉及含有所述化合物的药物组合物，以及使用所述化合物治疗神经和神经精神障碍的方法。
• 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones
  申请人：American Home Products Corporation

  公开号：US05948775A1

  公开（公告）日：1999-09-07

  This invention relates to 2- or 3-(substituted aminoalkoxyphenyl)quinazolin-4-ones which are partial estrogen agonists and are useful in treating osteoporosis, prostatic hypertrophy, breast cancer and endometrial cancer.

  这项发明涉及部分雌激素激动剂的2-或3-(取代氨基烷氧基苯基)喹唑啉-4-酮，可用于治疗骨质疏松症、前列腺肥大、乳腺癌和子宫内膜癌。
• Method of stimulating the heart employing ureido substituted
  申请人：Pfizer Inc.

  公开号：US03976783A1

  公开（公告）日：1976-08-24

  Method of stimulating the heart employing substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylamino-alkanes and .alpha.-aminoalkyl phenyl ketones is disclosed.

  揭示了一种利用取代的1-苯基-2-烷基氨基-烷醇、1-苯基-2-烷基氨基-烷烃和α-氨基烷基苯酮来刺激心脏的方法。
• Phenyl-alkanolamine, alkylamine and alpha-aminoalkyl ketone derivatives
  申请人：Pfizer Inc.

  公开号：US04086272A1

  公开（公告）日：1978-04-25

  Novel substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylamino-alkanes and .alpha.-aminoalkyl phenyl ketones useful as heart stimulants are disclosed.

  本发明公开了一种替代1-苯基-2-烷基氨基-烷醇，1-苯基-2-烷基氨基-烷烃和α-氨基烷基苯酮的小说，它们可用作心脏兴奋剂。
• Phenyl-alkanolamine, alkylamine and .alpha.-aminoalkyl ketone
  申请人：Pfizer Inc.

  公开号：US04137328A1

  公开（公告）日：1979-01-30

  Novel substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylaminoalkanes and .alpha.-aminoalkyl phenyl ketones useful as heart stimulants are disclosed.

  本发明揭示了一种替代1-苯基-2-烷基氨基-烷醇、1-苯基-2-烷基氨基烷和α-氨基烷基苯酮的新型化合物，它们可用作心脏兴奋剂。