N,N'-didodecyl-decanediamide | 96674-05-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-didodecyl-decanediamide
• 英文别名: N,N'-Didodecyl-decandiamid；Sebacinsaeure-bis-dodecylamid；N.N'-Didodecyl-sebacinamid；N,N'-didodecyldecanediamide
• CAS: 96674-05-4
• 化学式: C₃₄H₆₈N₂O₂
• 分子量: 536.926
• InChiKey: SCENHTFSVCQRQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.8
• 重原子数：
  38
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  十二烷基伯胺 、 N,N'-didodecyl-decanediamide 生成 C₅₈H₁₁₈N₄
  参考文献：
  名称：

  FR1542163

  摘要：

  公开号：
• 作为产物：
  描述：

  癸二酸 、 十二烷基伯胺 生成 N,N'-didodecyl-decanediamide
  参考文献：
  名称：

  High molecular weight aliphatic diamide of sebacic acid and process of preparing same

  摘要：

  公开号：

  US02304475A1

文献信息

• MacGregor; Ward, Journal of the Society of Chemical Industry, 1947, vol. 66, p. 345
  作者：MacGregor、Ward

  DOI：——

  日期：——
• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• US9006487B2
  申请人：——

  公开号：US9006487B2

  公开（公告）日：2015-04-14