2-acetoxy-5-hydroxy-benzoic acid | 79365-88-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetoxy-5-hydroxy-benzoic acid
• 英文别名: 2-Acetoxy-5-hydroxy-benzoesaeure；2-Acetyl-gentisinsaeure；2-(acetyloxy)-5-hydroxybenzoic acid；2-acetoxy-5-hydroxybenzoic acid；2-acetyloxy-5-hydroxybenzoic acid
• CAS: 79365-88-1
• 化学式: C₉H₈O₅
• 分子量: 196.16
• InChiKey: GWHXAZLLZVWMNI-UHFFFAOYSA-N

物化性质

• 熔点：
  171-173 °C(Solv: acetone (67-64-1); benzene (71-43-2))
• 沸点：
  405.8±40.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-acetoxy-5-hydroxy-benzoic acid 在 吡啶 、 盐酸 、 氯仿 、 溶剂黄146 作用下， 生成 5-benzoyloxy-2-hydroxy-benzoic acid
  参考文献：
  名称：

  Bergmann; Dangschat, Chemische Berichte, 1919, vol. 52, p. 383

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-bis(acetyloxy)benzoic acid 在 氨 作用下， 生成 2-acetoxy-5-hydroxy-benzoic acid
  参考文献：
  名称：

  Bergmann; Dangschat, Chemische Berichte, 1919, vol. 52, p. 383

  摘要：

  DOI：

文献信息

• Analgesic and anti-inflammatory compounds and compositions containing
  申请人：The Procter & Gamble Company

  公开号：US04276430A1

  公开（公告）日：1981-06-30

  Dihydroxybenzoic acid derivatives and compositions containing same are useful for topical application to the skin as well as for systemic administration. The compounds are especially effective for providing an analgesic, anti-pyretic, and anti-inflammatory effect.

  二羟基苯甲酸衍生物和含有它们的组合物可用于局部涂抹到皮肤上，也可用于全身给药。这些化合物特别有效地提供镇痛、退热和抗炎效果。
• COSMETIC
  申请人：Technoble Co., Ltd.

  公开号：EP0955032A1

  公开（公告）日：1999-11-10

  The cosmetic preparation inhibits the biosynthesis of melanin and onset of erythema, prevents the occurrence of inflammation, improves water content of the skin and thus, contributes to improved skin quality and to the prevention of skin aging. In addition, the preparation is less irritant and highly stable. The preparation contains the 2,5-dihydroxy benzoic acid derivatives expressed by Formula (I). [In formula (1), R1 is a hydrogen atom, an alkyl group with one to 20 carbons, an allylalkyl group with seven to nine carbons, an alkali metal atom or an alkaline-earth metal atom; R2 and R3 are independently a hydrogen atom, a group expressed by the formula -COR4 (R4 is an alkyl group with one to five carbons, an alkenyl group with one to three carbons, a methoxy group or a ethoxy group) or a phophoryl group. However, R2 and R3 should not be hydrogen atoms in an identical compound.]

  该化妆品制剂可抑制黑色素的生物合成和红斑的形成，防止炎症的发生，提高皮肤的含水量，从而有助于改善皮肤质量和防止皮肤老化。此外，该制剂刺激性小，稳定性高。该制剂含有由式（I）表示的 2,5-二羟基苯甲酸衍生物。 [在式 (1) 中，R1 是氢原子、1 至 20 个碳原子的烷基、7 至 9 个碳原子的烯丙基、碱金属原子或碱土金属原子；R2 和 R3 独立地是氢原子、由式 -COR4 表示的基团（R4 是 1 至 5 个碳原子的烷基、1 至 3 个碳原子的烯基、甲氧基或乙氧基）或 phophoryl 基团。但是，在相同的化合物中，R2 和 R3 不应是氢原子]。
• COSMETICS
  申请人：Technoble Co., Ltd.

  公开号：EP1366736A1

  公开（公告）日：2003-12-03

  Cosmetics containing an active component comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria; a skin brightening and caring agent comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria; and an emulsifier comprising as the main component lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria substantially in the absence of sodium chloride. Thus, cosmetics can be obtained, which are excellent in emulsion stability and biological safety, have a good feeling when using and after using and further have a total beautifying effect of cosmetic treatment including an improving effect on hair texture, and brightening and caring effects on the skin.

  一种化妆品，其活性成分包括乳酸菌发酵大米，该发酵大米是由乳酸菌发酵大米得到的；一种皮肤增白护理剂，该护理剂包括乳酸菌发酵大米，该发酵大米是由乳酸菌发酵大米得到的；以及一种乳化剂，其主要成分包括乳酸菌发酵大米，该乳酸菌发酵大米是由乳酸菌发酵大米得到的，基本上不含氯化钠。因此，可以获得乳液稳定性和生物安全性极佳、使用时和使用后感觉良好，并具有全面美容效果的化妆品，包括改善发质效果、美白和护理皮肤效果。
• ULTRAVIOLET-RAY SCREENING AGENT AND COSMETIC
  申请人：Shodoshima Healthy Land Co. Ltd.

  公开号：EP3323409A1

  公开（公告）日：2018-05-23

  Provided are a novel ultraviolet-ray screening agent and a novel cosmetic each having a high level of ultraviolet-ray screening function. The inventors have found that an extract from an olive branch has a high level of effect of absorbing ultraviolet rays, particularly UV-A and UV-B, and has a high level of ultraviolet-ray absorbing function, whereby the inventors have completed the present invention. The ultraviolet-ray screening agent according to the present invention includes an extract from an olive branch, wherein olive bark may be substituted for the olive branch. The ultraviolet-ray screening agent according to the present invention may be in the form of a cosmetic.

  本发明提供了一种新型紫外线屏蔽剂和一种新型化妆品，它们都具有高水平的紫外线屏蔽功能。本发明人发现，一种橄榄枝提取物具有高水平的吸收紫外线，特别是紫外线-A 和紫外线-B 的效果，并且具有高水平的紫外线吸收功能，因此本发明人完成了本发明。根据本发明的紫外线屏蔽剂包括从橄榄枝中提取的提取物，其中橄榄树皮可以代替橄榄枝。根据本发明的紫外线屏蔽剂可以是化妆品的形式。
• Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of glioma
  申请人：AmDerma Pharmaceuticals, LLC

  公开号：US10278941B2

  公开（公告）日：2019-05-07

  The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.

  本发明涉及式（I）的 2,5-二羟基苯衍生物或其药学上可接受的盐、溶液剂、异构体或原药在治疗和/或预防酒渣鼻等疾病中的用途。