3-hydroxymethyl-6-(2-methylpropyl)-2,5-diketopiperazine | 65519-48-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-hydroxymethyl-6-(2-methylpropyl)-2,5-diketopiperazine
• 英文别名: 3-hydroxymethyl-6-isobutyl-piperazine-2,5-dione；3-Hydroxymethyl-6-isobutyl-piperazin-2,5-dion；3-(Hydroxymethyl)-6-(2-methylpropyl)piperazine-2,5-dione
• CAS: 65519-48-4
• 化学式: C₉H₁₆N₂O₃
• 分子量: 200.238
• InChiKey: ANLAGVXTPHOKLD-UHFFFAOYSA-N

物化性质

• 沸点：
  509.4±35.0 °C(Predicted)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxymethyl-6-(2-methylpropyl)-2,5-diketopiperazine 在 硫酸 作用下， 生成 N-seryl-leucine
  参考文献：
  名称：

  Abderhalden; Bahn, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1935, vol. 234, p. 181,183

  摘要：

  DOI：
• 作为产物：
  描述：

  N-leucyl-serine 在 甲醇 作用下， 生成 3-hydroxymethyl-6-(2-methylpropyl)-2,5-diketopiperazine
  参考文献：
  名称：

  Abderhalden; Bahn, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1935, vol. 234, p. 181,183

  摘要：

  DOI：

文献信息

• AGRICULTURAL CHEMICAL CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Republic of Korea (Management: Rural Development Administration)

  公开号：EP2594134A2

  公开（公告）日：2013-05-22

  Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.

  本文公开了一种农用制剂，其活性成分含有能够控制植物病害和促进植物生长的 2,5-二酮哌嗪衍生物或其农业上可接受的盐。
• USE OF AN AGRICULTURAL AGENT CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Republic of Korea (Management: Rural Development Administration)

  公开号：EP2594134B1

  公开（公告）日：2017-08-02
• Telomere Shortening With Aging in Human Liver
  作者：K. Takubo、K.-I. Nakamura、N. Izumiyama、E. Furugori、M. Sawabe、T. Arai、Y. Esaki、K.-I. Mafune、M. Kammori、M. Fujiwara、M. Kato、M. Oshimura、K. Sasajima

  DOI：10.1093/gerona/55.11.b533

  日期：2000.11.1

  Progressive telomere shortening with aging was studied in the normal liver tissue of 94 human subjects aged between 0 and 101 years old to determine the rate of telomere loss in 1 year. Telomere length demonstrated age-related shortening with reduction of 55 base pairs (bp) per year. The mean telomere length in five neonates was 12.9 +/- 2.6 kilobase pairs (kbp), and that in one centenarian was 8.3 kbp, Mean telomere lengths by age group were 13.2 +/- 2.0 kbp (less than or equal to8 years; 10 subjects), 7.8 +/- 1.9 kbp (40-79 years; 29 subjects), and 7.5 +/- 2.0 kbp (greater than or equal to 80 years; 53 subjects), with reduction thus appearing to show slowing on the attainment of middle age. The difference of mean telomere lengths for two groups with or without advanced malignancies of other than liver origin was not significant in the older two groups. Despite the slow turnover of liver tissue, the overall reduction rate of telomere length decrease in 1 gear was almost the same as that of digestive tract mucosa, with its very rapid renewal.
• AGRICULTURAL AGENT CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Park Kyung Seok

  公开号：US20130190177A1

  公开（公告）日：2013-07-25

  Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.
• Abderhalden; Bahn, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1935, vol. 234, p. 181,183
  作者：Abderhalden、Bahn

  DOI：——

  日期：——