Boc-Leu-TrpOEt | 499192-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Leu-TrpOEt
• 英文别名: Boc-Leu-Trp-OEt；ethyl (2S)-3-(1H-indol-3-yl)-2-[[(2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]propanoate
• CAS: 499192-61-9
• 化学式: C₂₄H₃₅N₃O₅
• 分子量: 445.559
• InChiKey: XADRACODGWZAHS-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  BOC-L-亮氨酸 、 D-色氨酸乙酯盐酸盐 在 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate 作用下， 反应 48.0h， 以49%的产率得到Boc-Leu-TrpOEt
  参考文献：
  名称：

  Enzymatic Synthesis of Dipeptides in Ionic Liquids

  摘要：

  Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM. PF6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for biocatalysis.

  DOI：

  10.2174/157017810790796318

文献信息

• Enzymatic Synthesis of Dipeptides in Ionic Liquids
  作者：Sanjay Malhotra、Chengdong Zhang、Hao Wang

  DOI：10.2174/157017810790796318

  日期：2010.3.1

  Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM. PF6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for biocatalysis.