4-picoline(2,2':6',2''-terpyridine)platinum(II) tetrafluoroborate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-picoline(2,2':6',2''-terpyridine)platinum(II) tetrafluoroborate
• 英文别名: 2,6-dipyridin-2-ylpyridine;4-methylpyridine;platinum(2+);tetrafluoroborate
• 化学式: 2BF₄*C₂₁H₁₈N₄Pt
• 分子量: 695.09
• InChiKey: YHBIZGKETGAKNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.89
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4-picoline(2,2':6',2''-terpyridine)platinum(II) tetrafluoroborate 、 L-adenosine 在 sodium phosphate buffer 5.5 作用下， 以 水 为溶剂， 生成 N(1),N(6)-bis[(2,2':6',2''-terpyridine)platinio(II)]adenosin-6-ide tetrafluoroborate
  参考文献：
  名称：

  Reaction of 4-picoline(2,2′ :6′,2″-terpyridine)platinum(II) with nucleosides

  摘要：

  The four nucleosides found in DNA react with 4-picoline(2,2' -6',2 ''-terpyridine)platinum(II). Guanosine and 2'-deoxyguanosine are platinated at N-7. Adenosine and 2'-deoxyadenosine are platinated at both N-1 and N-6 With loss of a proton and there is no evidence of monoplatinated intermediates. It is proposed that platination occurs initially at N-1, the most nucleophilic site, which leads to loss of a proton from the N-6 amino function and subsequent rapid platination at this site. This conclusion is supported by NMR and mass spectral evidence. 2'-Deoxycytidine is similarly platinated at N-3 and N-4 and a similar explanation is proposed. Platination of thymidine is very slow and the product(s) has not been characterised.

  DOI：

  10.1039/p19960001499

文献信息

• Reaction of 4-picoline(2,2′ :6′,2″-terpyridine)platinum(<scp>II</scp>) with nucleosides
  作者：Gordon Lowe、Tirayut Vilaivan

  DOI：10.1039/p19960001499

  日期：——

  The four nucleosides found in DNA react with 4-picoline(2,2' -6',2 ''-terpyridine)platinum(II). Guanosine and 2'-deoxyguanosine are platinated at N-7. Adenosine and 2'-deoxyadenosine are platinated at both N-1 and N-6 With loss of a proton and there is no evidence of monoplatinated intermediates. It is proposed that platination occurs initially at N-1, the most nucleophilic site, which leads to loss of a proton from the N-6 amino function and subsequent rapid platination at this site. This conclusion is supported by NMR and mass spectral evidence. 2'-Deoxycytidine is similarly platinated at N-3 and N-4 and a similar explanation is proposed. Platination of thymidine is very slow and the product(s) has not been characterised.