N-(4-(cyanomethoxy)phenyl)acetamide | 60758-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-(cyanomethoxy)phenyl)acetamide
• 英文别名: N-[4-(cyanomethoxy)phenyl]acetamide
• CAS: 60758-89-6
• 化学式: C₁₀H₁₀N₂O₂
• mdl: MFCD00464960
• 分子量: 190.202
• InChiKey: VJODKPLEQTVVGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2-diaminoethane dihydrochloride 、 N-(4-(cyanomethoxy)phenyl)acetamide 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以65%的产率得到
  参考文献：
  名称：

  Raddatz, Rita; Savic, Sandra L.; Bakthavachalam, Venkatesalu, Journal of Pharmacology and Experimental Therapeutics, 2000, vol. 292, # 3, p. 1135 - 1145

  摘要：

  DOI：
• 作为产物：
  描述：

  对乙酰氨基酚 、 氯乙腈 在 potassium carbonate 作用下， 以 various solvent(s) 为溶剂， 反应 16.0h， 生成 N-(4-(cyanomethoxy)phenyl)acetamide
  参考文献：
  名称：

  Raddatz, Rita; Savic, Sandra L.; Bakthavachalam, Venkatesalu, Journal of Pharmacology and Experimental Therapeutics, 2000, vol. 292, # 3, p. 1135 - 1145

  摘要：

  DOI：

文献信息

• Synthesis and antimycobacterial activity of some isonicotinoylhydrazones
  作者：Maria T Cocco、Cenzo Congiu、Valentina Onnis、Maria C Pusceddu、Maria L Schivo、Alessandro De Logu

  DOI：10.1016/s0223-5234(99)00124-5

  日期：1999.12

  A series of isonicotinoylhydrazones 2 were prepared by addition of some aryloxyacetonitriles with isonicotinoylhydrazine in basic medium. These compounds have been further reacted with pyridinecarboxaldehydes to give the corresponding pyridylmethyleneamino derivatives 3-5. The new synthesized hydrazones and their pyridylmethyleneamino derivatives were tested for their activity against mycobacteria, Gram-positive and Gram-negative bacteria. The cytotoxicity was also tested. Several compounds showed a good activity against Mycobacterium tuberculosis H37Rv and some isonycotinoylhydrazones 2 showed a moderate activity against a clinically isolated M. tuberculosis which was isoniazid resistant. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
• Synthesis of Diverse γ-Lactams via Rh-Catalyzed C(sp²)–H Addition to Aliphatic Nitriles
  作者：Wenwei Li、Honggui Zhou、Yequan He、Ge Zeng、Yumeng Zheng、Yangni Hu、Zhongyan Chen、Jing-Yuan Ge、Ningning Lv、Jiuxi Chen

  DOI：10.1021/acs.orglett.2c01867

  日期：2022.7.22
• Raddatz, Rita; Savic, Sandra L.; Bakthavachalam, Venkatesalu, Journal of Pharmacology and Experimental Therapeutics, 2000, vol. 292, # 3, p. 1135 - 1145
  作者：Raddatz, Rita、Savic, Sandra L.、Bakthavachalam, Venkatesalu、Lesnick, John、Jasper, Jeffrey R.、McGrath, Christopher R.、Parini, Angelo、Lanier, Stephen M.

  DOI：——

  日期：——