(2R)-2-[[2-[3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-4H-pyridin-1-yl]-2-oxoethyl]amino]-4-methylsulfanylbutanoic acid | 1349739-51-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[[2-[3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-4H-pyridin-1-yl]-2-oxoethyl]amino]-4-methylsulfanylbutanoic acid
• CAS: 1349739-51-0
• 化学式: C₂₄H₂₉N₃O₉S
• 分子量: 535.575
• InChiKey: GWNAYPWKONTYHC-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  193
• 氢给体数：
  2
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  硝苯地平 在 三乙胺 作用下， 以 甲醇 、 苯 为溶剂， 反应 14.5h， 生成 (2R)-2-[[2-[3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-4H-pyridin-1-yl]-2-oxoethyl]amino]-4-methylsulfanylbutanoic acid
  参考文献：
  名称：

  氨基酸与硝苯地平结合物的抗氧化，抗炎和抗溃疡活性的合成和评价。

  摘要：

  新系列的新型（2S）-2-（{2- [1,4-二氢-3,5-双（甲氧羰基）-2,6-二甲基-4-（2-硝基苯基）吡啶-1-基]已经合成了-2-氧代乙基}氨基）-3-（4-羟基苯基）丙酸（3a）及其类似物3b-j。评价这些化合物的体外抗氧化活性，抗炎活性和抗溃疡活性。化合物3b和f显示出与标准品相当的显着抗氧化作用。还发现抗发炎和溃疡的功效很重要。根据光谱数据证实了这些化合物的化学结构。

  DOI：

  10.1248/cpb.59.1153

文献信息

• Differential Analogue Binding by Two Classes of c-di-GMP Riboswitches
  作者：Carly A. Shanahan、Barbara L. Gaffney、Roger A. Jones、Scott A. Strobel

  DOI：10.1021/ja204650q

  日期：2011.10.5

  The ability of bacteria to adapt to a changing environment is essential for their survival. One mechanism bacteria have evolved to sense environmental cues and translate these signals into phenotypic changes uses the second messenger signaling molecule, cyclic diguanosine monophosphate (c-di-GMP). In addition to several classes of protein receptors, two classes of c-di-GMP-binding riboswitches (class land class II) have been identified as downstream targets of the second messenger in this signaling pathway. The crystal structures of both riboswitch classes bound to c-di-GMP were previously reported. Here, we further investigate the mechanisms that RNA has evolved for recognition and binding of this second messenger. Using a series of c-di-GMP analogues, we probed the interactions made in the RNA ligand complex for both classes of riboswitches to identify the most critical elements of c-di-GMP for binding. We found that the structural features of c-di-GMP required for binding differ between these two effectors and that the class II riboswitch is much less discriminatory in ligand binding than the class I riboswitch. These data suggest an explanation for the predicted preferential use of the class I motif over the class II motif in the c-di-GMP signaling pathway.
• Synthesis and Evaluation of Antioxidant, Anti-inflammatory and Antiulcer Activity of Conjugates of Amino Acids with Nifedipine
  作者：Bharat Bhusan Subudhi、Shakti Prasanna Sahoo

  DOI：10.1248/cpb.59.1153

  日期：——

  (2S)-2-(2-[1,4-dihydro-3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridin-1-yl]-2-oxoethyl}amino)-3-(4-hydroxyphenyl) propanoic acid (3a) and its analogues 3b-j has been synthesized. These compounds were evaluated for their in vitro antioxidant activity, anti-inflammatory activity and antiulcer activity. Compounds 3b and f exhibited significant antioxidant action comparable with that of standard

  新系列的新型（2S）-2-（2- [1,4-二氢-3,5-双（甲氧羰基）-2,6-二甲基-4-（2-硝基苯基）吡啶-1-基]已经合成了-2-氧代乙基}氨基）-3-（4-羟基苯基）丙酸（3a）及其类似物3b-j。评价这些化合物的体外抗氧化活性，抗炎活性和抗溃疡活性。化合物3b和f显示出与标准品相当的显着抗氧化作用。还发现抗发炎和溃疡的功效很重要。根据光谱数据证实了这些化合物的化学结构。