(4-morpholin-4-ylmethylphenyl)piperazin-1-yl-methanone | 929622-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-morpholin-4-ylmethylphenyl)piperazin-1-yl-methanone
• 英文别名: (4-Morpholin-4-ylmethyl-phenyl)piperazin-1-yl-methanone；[4-(morpholin-4-ylmethyl)phenyl]-piperazin-1-ylmethanone
• CAS: 929622-20-8
• 化学式: C₁₆H₂₃N₃O₂
• 分子量: 289.378
• InChiKey: WPPQFCIZPCUPLE-UHFFFAOYSA-N

物化性质

• 沸点：
  462.1±45.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-morpholin-4-ylmethylphenyl)piperazin-1-yl-methanone 在 盐酸 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 生成 (4-cyclobutylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone
  参考文献：
  名称：

  Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

  摘要：

  The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H-3 receptor antagonists is described. The compounds described are high affinity histamine H-3 antagonists. Optimization of the physical properties of these histamine H-3 antagonists led to the discovery of several promising lead compounds, and extensive preclinical profiling aided in the identification of compounds with optimal duration of action for wake promoting activity. This led to the discovery of two development candidates for Phase I and Phase II clinical trials.

  DOI：

  10.1021/ml5005156
• 作为产物：
  描述：

  对醛基苯甲酸 在 4-二甲氨基吡啶 、 三乙酰氧基硼氢化钠 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 24.5h， 生成 (4-morpholin-4-ylmethylphenyl)piperazin-1-yl-methanone
  参考文献：
  名称：

  Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

  摘要：

  The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H-3 receptor antagonists is described. The compounds described are high affinity histamine H-3 antagonists. Optimization of the physical properties of these histamine H-3 antagonists led to the discovery of several promising lead compounds, and extensive preclinical profiling aided in the identification of compounds with optimal duration of action for wake promoting activity. This led to the discovery of two development candidates for Phase I and Phase II clinical trials.

  DOI：

  10.1021/ml5005156

文献信息

• CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
  申请人：Allison D. Brett

  公开号：US20070066821A1

  公开（公告）日：2007-03-22

  Certain cyclopropyl amines are histamine H 3 modulators useful in the treatment of histamine H 3 receptor mediated diseases.

  某些环丙胺是组胺H3调节剂，可用于治疗组胺H3受体介导的疾病。
• NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
  申请人：Mani S. Neelakandha

  公开号：US20070129351A1

  公开（公告）日：2007-06-07

  The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型的环丙基酰胺衍生物制备方法，用于治疗由组胺受体介导的疾病和病状。
• NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES
  申请人：Mani S. Neelakandha

  公开号：US20070197508A1

  公开（公告）日：2007-08-23

  The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型制备取代哌嗪基和二氮杂环巴豆酰胺的方法，可用于治疗组织胺受体介导的疾病和病况。
• Processes for the preparation of cyclopropyl-amide derivatives
  申请人：Janssen Pharmaceutica NV

  公开号：US08063206B2

  公开（公告）日：2011-11-22

  The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型的环丙基酰胺衍生物制备方法，用于治疗由组胺受体介导的疾病和病状。
• Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
  申请人：Janssen Pharmaceutica NV

  公开号：US07728129B2

  公开（公告）日：2010-06-01

  The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides of formula (I), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种用于制备式（I）中所定义的取代哌嗪基和二氮杂环基苯甲酰胺的新型方法，该方法可用于治疗由组胺受体介导的疾病和病症。