4-(4-morpholin-4-ylmethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-morpholin-4-ylmethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester
• 英文别名: 4-(4-Morpholin-4-ylmethyl-benzoyl)piperazine-1-carboxylic acid tert-butyl ester；tert-butyl 4-[4-(morpholin-4-ylmethyl)benzoyl]piperazine-1-carboxylate
• 化学式: C₂₁H₃₁N₃O₄
• 分子量: 389.495
• InChiKey: FERJZGGSAFXMCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  62.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(4-morpholin-4-ylmethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester 在 sodium cyanoborohydride 、 溶剂黄146 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 20.5h， 生成 (4-环丙基哌嗪-1-基)-[4-(吗啉-4-基甲基)苯基]甲酮
  参考文献：
  名称：

  Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

  摘要：

  The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H-3 receptor antagonists is described. The compounds described are high affinity histamine H-3 antagonists. Optimization of the physical properties of these histamine H-3 antagonists led to the discovery of several promising lead compounds, and extensive preclinical profiling aided in the identification of compounds with optimal duration of action for wake promoting activity. This led to the discovery of two development candidates for Phase I and Phase II clinical trials.

  DOI：

  10.1021/ml5005156
• 作为产物：
  描述：

  tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate 以48的产率得到4-(4-morpholin-4-ylmethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  ACS Med. Chem. Lett. 2015, 6, 450-454

  摘要：

  DOI：

文献信息

• Mechanochemical Nucleophilic Substitution of Alcohols via Isouronium Intermediates**
  作者：Tatsiana Dalidovich、Jagadeesh Varma Nallaparaju、Tatsiana Shalima、Riina Aav、Dzmitry G. Kananovich

  DOI：10.1002/cssc.202102286

  日期：2022.2.8

  Greener amine synthesis: Nucleophilic substitution of alcohols via reactive isouronium salts under mechanochemical one-jar reaction conditions is presented for the first time. The method opens access towards biologically active amines, including active pharmaceutical ingredients.

  更环保的胺合成：首次提出了在机械化学单罐反应条件下通过反应性异脲盐对醇进行的亲核取代。该方法打开了获得生物活性胺的途径，包括活性药物成分。
• CYCLOPROPYL AMINES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
  申请人：Allison D. Brett

  公开号：US20070066821A1

  公开（公告）日：2007-03-22

  Certain cyclopropyl amines are histamine H 3 modulators useful in the treatment of histamine H 3 receptor mediated diseases.

  某些环丙胺是组胺H3调节剂，可用于治疗组胺H3受体介导的疾病。
• NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
  申请人：Mani S. Neelakandha

  公开号：US20070129351A1

  公开（公告）日：2007-06-07

  The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型的环丙基酰胺衍生物制备方法，用于治疗由组胺受体介导的疾病和病状。
• NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES
  申请人：Mani S. Neelakandha

  公开号：US20070197508A1

  公开（公告）日：2007-08-23

  The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型制备取代哌嗪基和二氮杂环巴豆酰胺的方法，可用于治疗组织胺受体介导的疾病和病况。
• Processes for the preparation of cyclopropyl-amide derivatives
  申请人：Janssen Pharmaceutica NV

  公开号：US08063206B2

  公开（公告）日：2011-11-22

  The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型的环丙基酰胺衍生物制备方法，用于治疗由组胺受体介导的疾病和病状。