1氢-吲唑-4,7-二胺 | 918961-26-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 中文名称: 1氢-吲唑-4,7-二胺
• 英文名称: 4,7-diamine-1H-indazole
• 英文别名: 1H-indazole-4,7-diamine
• CAS: 918961-26-9
• 化学式: C₇H₈N₄
• mdl: MFCD16619752
• 分子量: 148.167
• InChiKey: HPDUOIDFHRYULE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P305+P351+P338,P332+P313,P337+P313,P362
• 危险性描述：
  H315,H319
• 储存条件：
  在2至8℃的温度下，并需氮气保护保存。

反应信息

• 作为反应物：
  描述：

  1氢-吲唑-4,7-二胺 在 盐酸 、 sodium chlorate 、 cerium(III) chloride 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 6-chloro-5-((4-fluorophenyl)amino)-1H-indazole-4,7-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt

  摘要：

  A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line.

  DOI：

  10.1016/j.bmcl.2006.08.120
• 作为产物：
  描述：

  7-硝基吲唑 在 platinum(IV) oxide 氢氧化钾 、 氢气 、 羟胺 作用下， 以 乙醇 为溶剂， 20.0~60.0 ℃ 、206.84 kPa 条件下， 反应 9.0h， 生成 1氢-吲唑-4,7-二胺
  参考文献：
  名称：

  Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt

  摘要：

  A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line.

  DOI：

  10.1016/j.bmcl.2006.08.120

文献信息

• Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
  申请人：Glenn Wayne Robert

  公开号：US20060042026A1

  公开（公告）日：2006-03-02

  Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one bicyclic 5-6 systems of aza heteroaromatic keratin dyeing compounds wherein the 5-membered rings have one to three nitrogen atoms and an N-hydroxy or N-amino group and derivatives thereof. A method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.

  氧化染色角蛋白纤维的组合物，包括适用于染色的介质和至少一种含有杂环芳香族角蛋白染料化合物的双环5-6系统，其中5个成员环具有一到三个氮原子和一个N-羟基或N-氨基团及其衍生物。一种氧化染色角蛋白纤维的方法，包括在氧化剂存在下应用这种组合物，持续足够时间以发展所需的着色。
• Dyestuff composition for the gradual dyeing of hair by atmospheric oxidation and process using the same
  申请人：COMBE INCORPORATED

  公开号：EP0593038A1

  公开（公告）日：1994-04-20

  A dyestuff composition for gradually dyeing hair by atmospheric oxidation wherein the dyestuff composition contains a dye component which becomes entrapped in hair fibers when the dyestuff composition is removed from the hair and which results in the gradual development of color in the hair due to atmospheric oxidation of the entrapped dye component. Also provided is a process of employing the dyestuff composition of this invention to gradually dye hair, the dyestuff composition being removed from the hair approximately 5 minutes after its application.

  一种用于通过大气氧化逐渐染发的染料组合物，其中染料组合物含有一种染料成分，当染料组合物从头发上去除时，该染料成分会被夹杂在头发纤维中，由于被夹杂的染料成分被大气氧化，导致头发逐渐显色。本发明还提供了一种使用本发明染料组合物逐渐染发的工艺，在使用本发明染料组合物约 5 分钟后，将其从头发上去除。
• US4104020A
  申请人：——

  公开号：US4104020A

  公开（公告）日：1978-08-01
• US5350424A
  申请人：——

  公开号：US5350424A

  公开（公告）日：1994-09-27
• US7371264B2
  申请人：——

  公开号：US7371264B2

  公开（公告）日：2008-05-13