N-{[4-(1,1-dimethylethyl)phenyl]methyl}benzenecarboximidamide | 1039764-12-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{[4-(1,1-dimethylethyl)phenyl]methyl}benzenecarboximidamide
• 英文别名: N'-[(4-tert-butylphenyl)methyl]benzenecarboximidamide
• CAS: 1039764-12-9
• 化学式: C₁₈H₂₂N₂
• 分子量: 266.386
• InChiKey: BPOGQVKKUFEYDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-{[4-(1,1-dimethylethyl)phenyl]methyl}benzenecarboximidamide 在 sodium methylate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 ethyl N-[(1-{[4-(1,1-dimethylethyl)phenyl]methyl}-4-hydroxy-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinyl)carbonyl]glycinate
  参考文献：
  名称：

  N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors

  摘要：

  本发明涉及某些式（I）的嘧啶二酮N-取代甘氨酸衍生物，这些衍生物是HIF脯氨酸羟化酶的拮抗剂，并且适用于治疗受益于抑制该酶的疾病，贫血是一个例子。

  公开号：

  US20080171756A1
• 作为产物：
  描述：

  4-叔-丁基苄胺 、 苯甲腈 在 二甲基氯化铝 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 6.5h， 生成 N-{[4-(1,1-dimethylethyl)phenyl]methyl}benzenecarboximidamide
  参考文献：
  名称：

  N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors

  摘要：

  本发明涉及某些式（I）的嘧啶二酮N-取代甘氨酸衍生物，这些衍生物是HIF脯氨酸羟化酶的拮抗剂，并且适用于治疗受益于抑制该酶的疾病，贫血是一个例子。

  公开号：

  US20080171756A1

文献信息

• Base-promoted formal [4 + 1+1] annulation of aldehyde, N -benzyl amidine and DMSO toward 2,4,6-triaryl pyrimidines
  作者：Jin Yuan、Jingbo Li、Bingbing Wang、Song Sun、Jiang Cheng

  DOI：10.1016/j.tetlet.2017.11.020

  日期：2017.12

  A base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO was developed, leading to a series of 2,4,6-triaryl pyrimidines in moderate to good yields. Notably, DMSO served as a methine source, which was activated by base rather than either Lewis acid or electrophile. Molecular O-2 was the sole eco-friendly oxidant during this procedure. (C) 2017 Published by Elsevier Ltd.
• [EN] MULTI-COMPONENT HOST MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME<br/>[FR] MATÉRIAU HÔTE À PLUSIEURS COMPOSANTS ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE LE COMPRENANT
  申请人：ROHM & HAAS ELECT MAT

  公开号：WO2015156587A1

  公开（公告）日：2015-10-15

  The present invention relates to an organic electroluminescent device comprising at least one light-emitting layer between an anode and a cathode, wherein the light-emitting layer comprises a host and a phosphorescent dopant; the host consists of multi-component host compounds; at least a first host compound of the multi-component host compounds is a specific bicarbazole derivative containing an aryl group, and a second host compound is a specific carbazole derivative including a nitrogen-containing heteroaryl group. According to the present invention, the organic electroluminescent device using the multi-component host compounds has a high efficiency and long lifespan compared with the conventional device using one component host compound.