(Z)-2-Chloro-but-2-enoic acid | 53993-41-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-2-Chloro-but-2-enoic acid
• 英文别名: (Z)-2-chlorobut-2-enoic acid；Z-2-chloro-2-butenoic acid；α-Chlor-crotonsaeure；(Z)-2-chloro-2-butenoic acid；2-Chlorbut-2-ensaeure；2-Chlorobut-2-enoic acid
• CAS: 53993-41-2
• 化学式: C₄H₅ClO₂
• 分子量: 120.535
• InChiKey: WMDBQMYVAIBBDH-IHWYPQMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-2-Chloro-but-2-enoic acid 在 盐酸 作用下， 生成 (+/-)-threo-2,3-dichloro-butyric acid
  参考文献：
  名称：

  Michael; Schulthess, Journal fur praktische Chemie (Leipzig 1954), 1892, vol. <2>46, p. 263

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二羟基甲苯 生成 (Z)-2-Chloro-but-2-enoic acid
  参考文献：
  名称：

  Tretyakova Natalla Yu., Lebedev Albert T., Petrosyan Valery S., Environ. Sci. and Technol., 28 (1994) N 4, S 606-613

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE TYROSINE KINASE DE BRUTON ET LEURS PROCÉDÉS D'UTILISATION
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2018103058A1

  公开（公告）日：2018-06-14

  Compounds of formula (I') and methods of their use and preparation, as well as compositions comprising compounds of formula (I').

  公式（I'）的化合物及其使用和制备方法，以及包含公式（I'）化合物的组合物。
• Synthesis of Antibiotics. I. Synthesis of N-Substituted Compounds of Monochloroacylamide and Their Antitrichophyton Effect
  作者：Isoo Ito

  DOI：10.1248/cpb.14.561

  日期：——

  Thirteen kinds of monohalogenoacyl substituted aromatic derivatives were synthesized and tested their antitrichophyton effect. On anilide, Cl substitution of p-position is 30 times as strong as that of o-position, and Cl substitution is 33 times as strong as Br substitution. The double bond of acyl group of monohalogenoacyl substituted aromatic amide derivatives did not show strong fungical effect, and there was no difference of fungical effect between cis and trans.

  合成了13种单卤代乙酰基取代芳香族衍生物并测试了它们的抗癣菌效果。在苯胺中，氯在苯环对位的取代活性比在邻位的强30倍，氯的取代活性比溴强33倍。单卤代乙酰基取代芳香族酰胺衍生物酰基上的双键不呈现很强的抗菌效果，顺反式抗菌效果也没有差别。
• Reaction of activated vinyl halides with tervalent phosphorus nucleophiles
  作者：Gerald Pattenden、Brian J. Walker

  DOI：10.1039/j39690000531

  日期：——

  cis- and trans- Isomers of derivatives of 3-halogenoacrylic acids undergo nucleophilic displacement reactions with triphenylphosphine, tri-n-butylphosphine, and triethyl phosphite to produce the correspondingtrans-vinyl-phosphonium salts and -phosphonates exclusively. 1H n.m.r.spectra are reported for these compounds. The mechanism of the displacement reaction is discussed.

  3-卤代丙烯酸衍生物的顺式和反式异构体与三苯基膦，三正丁基膦和亚磷酸三乙酯进行亲核取代反应，仅生成相应的反式-乙烯基-盐和-膦酸酯。据报道这些化合物的1 H nmr光谱。讨论了置换反应的机理。
• Streambank and vegetation response to simulated cattle grazing
  作者：Warren P. Clary、John W. Kinney

  DOI：10.1672/0277-5212(2002)022[0139:savrts]2.0.co;2

  日期：2002.3

  Simulated grazing techniques were used to investigate livestock impacts on structural and vegetation characteristics of streambanks in central Idaho, USA. The treatments, continued over two years, consisted of no grazing, simulated moderate early summer grazing, simulated moderate mid-summer grazing, and simulated heavy season-long grazing. The moderate treatments depressed the streambank surface about 3 cm, while the heavy season-long treatment resulted in an 11.5-cm depression. There were no differences between the no-grazing and moderate-grazing treatments for change in stream width, bank angle, bank retreat, or root biomass. The heavy season-long treatment, however, produced significant changes in these variables. The amount of foliage biomass (i.e., kg ha(-1)) removed by treatment was similar between the two years of study for the moderate treatments. The foliage removed from the heavy season-long treatment plots greatly decreased in the second year as plant growth decreased. Ten months after the last treatment application, the average spring foliage growth was 20-43% lower on the moderate treatment plots and 51-87% lower on the heavy season-long treatment plots than on the untreated control plots.
• Friedrich, Justus Liebigs Annalen der Chemie, 1883, vol. 219, p. 370
  作者：Friedrich

  DOI：——

  日期：——