4-diazomethyl-7-methoxycoumarin | 84471-16-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-diazomethyl-7-methoxycoumarin
• 英文别名: 4-[(Z)-diazomethyl]-7-methoxychromen-2-one
• CAS: 84471-16-9
• 化学式: C₁₁H₈N₂O₃
• 分子量: 216.196
• InChiKey: XNQDQLVCJSWRIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-diazomethyl-7-methoxycoumarin 以 甲苯 为溶剂， 以90%的产率得到7-Methoxy-3H-chromeno[3,4-c]pyrazol-4-one
  参考文献：
  名称：

  Ito, Keiichi; Maruyama, Junko, Heterocycles, 1984, vol. 22, # 5, p. 1057 - 1059

  摘要：

  DOI：
• 作为产物：
  描述：

  7-甲氧基香豆素-4-腙 在 magnesium sulfate 、 silver(l) oxide 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以80%的产率得到4-diazomethyl-7-methoxycoumarin
  参考文献：
  名称：

  Ito, Keiichi; Sawanobori, Junko, Synthetic Communications, 1982, vol. 12, # 9, p. 665 - 672

  摘要：

  DOI：

文献信息

• Silver‐Catalyzed [3+2] Cycloaddition Approach to Coumarin‐Decorated Tetrazoles
  作者：Xuan‐Yu Liu、Shi‐Jing Zhai、Fang‐Fang Feng、Fa‐Guang Zhang、Jun‐An Ma

  DOI：10.1002/cctc.202001143

  日期：2020.11.19

  A silver‐catalyzed regioselective 1,3‐dipolar cycloaddition transformation of coumarin‐diazo building blocks with arenediazonium salts was documented. This simple and scalable reaction pattern offers a variety of coumarin‐decorated tetrazoles in good yields with excellent regioselectivities.

  记录了银与苯二氮杂鎓盐对香豆素-重氮构建基的区域选择性1,3-偶极环加成转化。这种简单且可扩展的反应模式提供了多种香豆素修饰的四唑，具有良好的产率和极好的区域选择性。
• Regioselective Construction of Coumarin-1,2,4-triazines via a Cs2CO3-Catalyzed [3+3] Cycloaddition Reaction
  作者：Fa-Guang Zhang、Jun-An Ma、Xuan-Yu Liu

  DOI：10.1055/a-1828-7504

  日期：2022.7

  A cesium carbonate (Cs2CO3)-catalyzed [3+3] cycloaddition reaction of coumarin-diazo reagents with glycine imino esters is established to produce tetrahydro-1,2,4-triazines in good yields with excellent regioselectivity. One-pot cycloaddition/oxidation protocol could further provide practical access to a series of new coumarin-decorated 1,2,4-triazines.

  建立了碳酸铯（Cs 2 CO 3）催化的香豆素-重氮试剂与甘氨酸亚氨基酯的[3+3]环加成反应，以良好的收率和区域选择性生产四氢-1,2,4-三嗪。一锅环加成/氧化方案可以进一步提供一系列新的香豆素修饰的 1,2,4-三嗪的实用途径。
• [EN] OPTICALLY ACTIVE DEVICES<br/>[FR] DISPOSITIFS OPTIQUEMENT ACTIFS
  申请人：MERCK PATENT GMBH

  公开号：WO2022128832A1

  公开（公告）日：2022-06-23

  The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive chromophore, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices. The present invention is also directed to a process of changing the optical properties of said ophthalmic device or a precursor article for an ophthalmic device.

  本发明涉及新型眼科装置，其中包括聚合物化合物，其中包括光活性色团，所述聚合物化合物和特殊单体化合物特别适用于组成和眼科装置。本发明还涉及一种改变所述眼科装置或用于眼科装置的前体文章的光学特性的方法。
• INDICATOR FOR ASSESSING BODY ODOR, PROCESS FOR PRODUCING THE SAME, BODY ODOR ASSESSMENT METHOD, METHOD OF ASSESSING EFFICACIOUSNESS OF DEODORANT AND KIT FOR CONVENIENTLY ASSESING BODY ODOR
  申请人：Kao Corporation

  公开号：EP1553411A1

  公开（公告）日：2005-07-13

  An indicator material for assessing body odor of the present invention comprises at least one member selected from the group consisting of a substance (A) which is a β-hydroxycarboxylic acid compound represented by the formula (1), a substance (B) which is a derivative of the compound represented by the formula (1), a substance (C) which is an alcohol compound having a mercapto group at the 3-position represented by the formula (2),and a substance (D) which is a derivative of the compound represented by the formula (2). The present invention also provides a method of producing the compound represented by the formula (2) by incubating perspiration originated from a human in an environment with an oxygen concentration of 10 v/v% or less. The present invention also provides a kit for assessing body odor of a human, wherein the kit for assessing body odor of a human includes a coloration reagent which reacts with β-hydroxycarboxylic acid originated from perspiration of a human. wherein R1 is an alkyl having 1 to 4 carbons; R2 is a hydrogen atom or an alkyl having 1 to 4 carbons, and the total number of carbons in the formula (1) is 10 or less; wherein R3 is a hydrogen atom or methyl group; R4 is an alkyl group having 1 to 3 carbons; and R5 is a hydrogen atom or a methyl group, the total number of carbons is 8 or less.

  本发明的一种用于评估体味的指示剂材料包括至少一种选自以下组成的成员：一种物质（A），它是β-羟基羧酸化合物，由式（1）表示；一种物质（B），它是由式（1）表示的化合物的衍生物；一种物质（C），它是由式（2）表示的在3-位上具有巯基的醇化合物；以及一种物质（D），它是由式（2）表示的化合物的衍生物。本发明还提供了一种通过在氧气浓度为 10 v/v% 或更低的环境中培养人的汗液来生产式（2）所代表的化合物的方法。本发明还提供了一种用于评估人的体味的试剂盒，其中用于评估人的体味的试剂盒包括一种与源自人的汗液的β-羟基羧酸反应的着色试剂。 其中 R1 是具有 1 至 4 个碳原子的烷基；R2 是氢原子或具有 1 至 4 个碳原子的烷基，且式（1）中的碳原子总数为 10 或更少； 其中 R3 是氢原子或甲基；R4 是具有 1 至 3 个碳原子的烷基；R5 是氢原子或甲基，碳原子总数为 8 或更少。
• OPTICALLY ACTIVE DEVICES
  申请人：AMO Ireland

  公开号：EP4015512A1

  公开（公告）日：2022-06-22

  The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive chromophore, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices. The present invention is also directed to a process of changing the optical properties of said ophthalmic device or a precursor article for an ophthalmic device.

  本发明涉及新型眼科设备，该设备由包含光活性发色团的聚合化合物组成，所述聚合化合物和特殊单体化合物特别适用于组合物和眼科设备。本发明还涉及一种改变所述眼科设备或眼科设备前体制品光学特性的工艺。