3-azido-1,8-naphthalic anhydride | 1073775-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-azido-1,8-naphthalic anhydride
• 英文别名: 7-Azido-3-oxatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaene-2,4-dione
• CAS: 1073775-48-0
• 化学式: C₁₂H₅N₃O₃
• 分子量: 239.19
• InChiKey: CSXRBQXSGPAMKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-azido-1,8-naphthalic anhydride 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 乙醇 、 水 、 叔丁醇 为溶剂， 生成 N-(2-hydroxyethyl)-3-(1,2,3-triazol-1-yl)-1,8-naphthalimide
  参考文献：
  名称：

  Novel efficient anticancer agents and DNA-intercalators of 1,2,3-triazol-1,8-naphthalimides: design, synthesis, and biological activity

  摘要：

  Two novel series of 3-1,2,3-triazol-1,8-naphthalimides 5a-e, 7a-e were synthesized easily by employing 'click reaction'. Their bioactivities were evaluated. Compounds 5a-e were found to be more toxic against MCF-7 cells while 7a-e were more potent against 7721 cells, in particular 7a, the IC50 value of which against cell lines of MCF-7 and 7721 was 0.348 mu M and 0.258 mu M, respectively. Due to the phenyl group linked to 1,2,3-triazole, compound 5a not only showed higher DNA affinity but also more efficient DNA damaging ability than compound 7a. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.063
• 作为产物：
  描述：

  3-硝基-1,8-萘二甲酸酐 在 盐酸 、 palladium 10% on activated carbon 、 氢气 、 溶剂黄146 、 sodium nitrite 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 60.0 ℃ 、1.5 MPa 条件下， 反应 6.83h， 生成 3-azido-1,8-naphthalic anhydride
  参考文献：
  名称：

  Novel efficient anticancer agents and DNA-intercalators of 1,2,3-triazol-1,8-naphthalimides: design, synthesis, and biological activity

  摘要：

  Two novel series of 3-1,2,3-triazol-1,8-naphthalimides 5a-e, 7a-e were synthesized easily by employing 'click reaction'. Their bioactivities were evaluated. Compounds 5a-e were found to be more toxic against MCF-7 cells while 7a-e were more potent against 7721 cells, in particular 7a, the IC50 value of which against cell lines of MCF-7 and 7721 was 0.348 mu M and 0.258 mu M, respectively. Due to the phenyl group linked to 1,2,3-triazole, compound 5a not only showed higher DNA affinity but also more efficient DNA damaging ability than compound 7a. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.063

文献信息

• Photoacid generator and chemically amplified positive-type photoresist composition for thick film comprising the same
  申请人：LG CHEM, LTD.

  公开号：US11150555B2

  公开（公告）日：2021-10-19

  A non-ionic photoacid generator and a chemically amplified positive-type photoresist composition for a thick film including the non-ionic photoacid generator. The non-ionic photoacid generator may not only exhibit high solubility in a solvent of the photoresist composition, but may also exhibit chemical and thermal stability and high sensitivity. In particular, the non-ionic photoacid generator is decomposed by light to generate an acid, and at the same time, can exhibit a corrosion preventing effect on a metal substrate.

  一种非离子光酸发生器和一种用于厚膜的化学放大正型光刻胶组合物，包括该非离子光酸发生器。非离子光酸发生器不仅在光刻胶组合物的溶剂中具有高溶解性，还具有化学稳定性、热稳定性和高灵敏度。特别是，非离子光酸发生器在光的作用下分解生成酸，同时还能对金属基底起到防腐蚀作用。
• PHOTOACID GENERATOR AND CHEMICALLY AMPLIFIED POSITIVE-TYPE PHOTORESIST COMPOSITION FOR THICK FILM COMPRISING THE SAME
  申请人：LG CHEM, LTD.

  公开号：US20200033724A1

  公开（公告）日：2020-01-30

  A non-ionic photoacid generator and a chemically amplified positive-type photoresist composition for a thick film including the non-ionic photoacid generator. The non-ionic photoacid generator may not only exhibit high solubility in a solvent of the photoresist composition, but may also exhibit chemical and thermal stability and high sensitivity. In particular, the non-ionic photoacid generator is decomposed by light to generate an acid, and at the same time, can exhibit a corrosion preventing effect on a metal substrate.