6-叠氮-7H-嘌呤 | 7086-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 6-叠氮-7H-嘌呤
• 英文名称: 6-azidopurine
• 英文别名: 6-Azido-purin；6-azido-7(9)H-purine；6-Azido-9H-purine；6-azido-7H-purine
• CAS: 7086-34-2
• 化学式: C₅H₃N₇
• 分子量: 161.126
• InChiKey: PNRIXVQOZMTFOW-UHFFFAOYSA-N

物化性质

• 熔点：
  185 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-叠氮-7H-嘌呤 在 水 、 镍 作用下， 生成 腺嘌呤
  参考文献：
  名称：

  Bendich et al., Ciba Found.Symp.Chem.Biol.Purines 1957 S.3,10

  摘要：

  DOI：
• 作为产物：
  描述：

  6-肼基嘌呤 在 溶剂黄146 、 sodium nitrite 作用下， 生成 6-叠氮-7H-嘌呤
  参考文献：
  名称：

  Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases

  摘要：

  Previously reported structural fragments that associate with the ATP-binding pocket of basophilic protein kinases were conjugated with D-arginine-containing peptides. Inhibitory potency of the resulting bisubstrate-analog inhibitors towards PKA and ROCK-II extended to subnanomolar range. The conjugates incorporating 2-pyrimidyl-5-amidothiophene fragment had the highest activity and at 100 nM concentration exhibited over 80% inhibition of most of the tested basophilic kinases of the AGC group. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.026

文献信息

• Mitsunobu Reactions for the Synthesis of Carbocyclic Analogues of Nucleosides: Examination of the Regioselectivity¹
  作者：Akemi Toyota、Nobuya Katagiri、Chikara Kaneko

  DOI：10.1080/00397919308011216

  日期：1993.5

  In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.
• Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases
  作者：Erki Enkvist、Marie Kriisa、Mart Roben、Grete Kadak、Gerda Raidaru、Asko Uri

  DOI：10.1016/j.bmcl.2009.09.026

  日期：2009.11

  Previously reported structural fragments that associate with the ATP-binding pocket of basophilic protein kinases were conjugated with D-arginine-containing peptides. Inhibitory potency of the resulting bisubstrate-analog inhibitors towards PKA and ROCK-II extended to subnanomolar range. The conjugates incorporating 2-pyrimidyl-5-amidothiophene fragment had the highest activity and at 100 nM concentration exhibited over 80% inhibition of most of the tested basophilic kinases of the AGC group. (C) 2009 Elsevier Ltd. All rights reserved.
• Bendich et al., Ciba Found.Symp.Chem.Biol.Purines 1957 S.3,10
  作者：Bendich et al.

  DOI：——

  日期：——